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A prodepressive dopamine receptor complex in brain mediates sex differences in depression and anxiety: validation and strategies for drug discovery

  • Program Type

    Team grants

  • Area of research

    Mental Health

  • Disease Area

    Mental illness

  • Competition

    Basics of Better Mental Health

  • Province

    Ontario

  • Start Date

    2024

  • Total Grant Amount

    $1,100,000

Project Overview

Major depression is common, highly prevalent, potentially lethal, affecting 10% of individuals with significant increase between 2015-2020, and 2-3-fold higher incidence in women compared to men. No cause for this sex difference is known, nor is it addressed by available treatments. Current antidepressants targeting serotonin/noradrenergic systems are ineffective in many,…

Developing open-science resources to map transgenerational, sex-specific effects of peripartum neuropsychiatric disease

  • Program Type

    Team grants

  • Area of research

    Mental Health

  • Disease Area

    Mental illness

  • Competition

    Basics of Better Mental Health

  • Province

    Ontario

  • Start Date

    2024

  • Total Grant Amount

    $1,100,000

Project Overview

Pregnancy and the postpartum period are high risk for depression onset and other psychiatric disorders in the birthing parent. Up to 20% of females experience postpartum depression, which not only impacts maternal health, but has transgenerational impact on children’s neurodevelopmental and mental health risk. Boys are more likely to develop…

Insulin resistance in the mesolimbic system, a novel hypothesis for depression associated with metabolic resistance from obesity.

  • Program Type

    Team grants

  • Area of research

    Mental Health

  • Disease Area

    Mental illness

  • Competition

    Basics of Better Mental Health

  • Province

    Alberta

  • Start Date

    2024

  • Total Grant Amount

    $1,100,000

Project Overview

Depression and anxiety are highly prevalent in people with obesity and type 2 diabetes. There are several theories of the cause of this association, however one commonality amongst these theories is that insulin, a hormone released after meals, becomes ineffective in obesity or type 2 diabetes and no longer regulates…

Spatial-temporal determinants of NMJs: from genes to function

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2024

  • Total Grant Amount

    $30,000

Project Overview

Amyotrophic lateral sclerosis (ALS) is a disease where motor neurons, neurons that control the muscles to generate fundamental movements in our daily life, are gradually destroyed during the disease leading to paralysis and eventually death. However, the death of motor neurons is preceded by the destruction of their contact with…

Relevance of stress granule dynamics to ALS pathogenesis in vivo

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2024

  • Total Grant Amount

    $300,000

Project Overview

Amyotrophic lateral sclerosis (ALS) also known as Lou Gehrig’s Disease, is a neurodegenerative disease for which there is no effective treatment. The disease affects motor neurons, which are nerve cells that control the voluntary movement of muscles. These cells are under constant stress in ALS patients and eventually die, resulting…