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542 results found

Spatial-temporal determinants of NMJs: from genes to function

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2024

  • Total Grant Amount

    $30,000

Project Overview

Amyotrophic lateral sclerosis (ALS) is a disease where motor neurons, neurons that control the muscles to generate fundamental movements in our daily life, are gradually destroyed during the disease leading to paralysis and eventually death. However, the death of motor neurons is preceded by the destruction of their contact with…

Relevance of stress granule dynamics to ALS pathogenesis in vivo

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2024

  • Total Grant Amount

    $300,000

Project Overview

Amyotrophic lateral sclerosis (ALS) also known as Lou Gehrig’s Disease, is a neurodegenerative disease for which there is no effective treatment. The disease affects motor neurons, which are nerve cells that control the voluntary movement of muscles. These cells are under constant stress in ALS patients and eventually die, resulting…

Correlating quaternary structure of pathological protein aggregates with phenotypic presentation of ALS

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2024

  • Total Grant Amount

    $125,000

Project Overview

Amyotrophic lateral sclerosis (ALS) is a disease of progressive weakness that leads to death within a few years of onset. The disease can start in one arm, leg, or face, but it inevitably spreads to all areas, killing cells as it spreads. What if, once the disease starts, we could…

Investigating mechanisms of altered lipid droplet dynamics in ALS

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2024

  • Total Grant Amount

    $125,000

Project Overview

In Canada, the annual cost to care for individuals with neurodegenerative diseases is over $10.4 billion. There are no therapeutic interventions that sufficiently prevent or treat neurodegenerative diseases because the cause of neurodegeneration is complex and not well understood. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease caused by…

Investigating inhibition of TDP-43 propagation as a therapeutic strategy for ALS

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2024

  • Total Grant Amount

    $125,000

Project Overview

It is not known why ALS is a rapidly progressing disease. The discovery that the accumulation of TAR DNA-binding protein 43 kDa (TDP-43) is a pathological hallmark of sporadic ALS and a subset of frontotemporal lobar degeneration (FTLD) provides clues. TDP-43 is prone to incorrect folding and it has been…