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Our directory of funded grants

5 result(s) found

Characterization of MATR3 Mutations Associated with ALS

Project Overview

For this project, Dr. Park will examine how abnormalities in RNA binding proteins (RBPs) – in particular, one called Matrin 3 (MATR3) – can lead to ALS. MATR3 was discovered to be a genetic cause of ALS in 2014 and has yet to be studied in any detail. By creating the first-ever cell, fruit fly a…

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Principal Investigator:
  • Jeehye Park, University of Toronto

Discovery of transcriptomic biomarkers and epigenetic therapeutic targets for c9ALS and sALS

Project Overview

Dr. Belzil began her research career as a PhD student at the Université de Montréal under the guidance of world renowned geneticist and Director of the Montreal Neurological Institute and Hospital, Dr. Guy Rouleau. During this time, Dr. Belzil pursued a better understanding of the genetics behind …

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Principal Investigator:
  • Veronique Belzil, Mayo Clinic

Mechanisms of glutamatergic neuronal dysfunction in genetic models of ALS

Project Overview

This project will focus on comprehensively studying impaired transmission of signals (from the brain) at the location where neurons and muscles meet, called the neuromuscular junction.  Recent evidence from a number of labs has indicated that errors in neurotransmission of signals might be one of t…

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Principal Investigator:
  • Gary Armstrong, CHUM Research Centre, University of Montréal

Mechanisms of Synaptic Dysfunction in Amyotrophic Lateral Sclerosis

Project Overview

This project will focus on unique roles of FUS (an ALS gene/protein) at the junction where neurons connect, called the synapse. Most of the work done on FUS focuses on its functions in the central region of the neuron called the cell body. When there is a mutation in the FUS gene, it causes ALS and …

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Principal Investigator:
  • Chantelle Sephton, Université Laval

Pathogenic mechanisms of C9ORF72 repeat expansion in ALS and development of therapeutics

Project Overview

Dr. Patten started his research career as a PhD student at the University of Alberta under the supervision of Dr. Declan Ali in 2004. There he trained in electrophysiology, cell biology and imaging using zebrafish as a model to study neurodevelopment. After publishing several manuscripts on his disc…

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Principal Investigator:
  • Kessen Patten, Centre INRS-Institut Armand Frappier