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Our directory of funded grants

2 result(s) found

Development of novel oligonucleotide delivery modalities for Huntington disease

Project Overview

Huntington disease (HD) is an inherited neurodegenerative disease that affects approximately 1 in 7500 individuals in the Western world. The cause of HD is a mutation in one copy of the HTT gene, which produces the toxic mutant huntingtin protein responsible for the brain cell loss associated with t…

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Principal Investigator:
  • Blair Leavitt, University of British Columbia
Team Members:
  • Danica Stanimirovic, National Research Council of Canada
  • Abedelnasser Abulrob, National Research Council of Canada
  • Jodi McBride, Oregon Health and Science University

Gangliosides in Huntington’s disease: from bench to clinics and back

Project Overview

Huntington disease (HD) is an inherited disorder that causes progressive malfunctioning and death of parts of the brain that control movement, reasoning and emotions. HD patients also suffer from depression and personality changes.  There is no cure for HD. Symptoms progress steadily until patients…

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Principal Investigator:
  • Simonetta Sipione, University of Alberta
Team Members:
  • Jonathan Curtis, University of Alberta
  • Sylvain Chouinard, CHUM Research Centre, University of Montréal
  • Oksana Suchowersky, University of Alberta
  • Justyna Sarna, University of Calgary
  • Richard Fahlman, University of Alberta