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Our directory of funded grants

7 result(s) found

Drug repurposing in medulloblastoma using integrated functional genomic, epigenomic, and transcriptomic approaches

Project Overview

The project conducted by Dr. Gendoo is focused upon identifying potential therapeutic targets against Medulloblastoma (MB) subtypes. Identification of subtype-specific therapies is contingent upon: 1) proper classification of samples into MB subtypes; and 2) proper understanding of the pharmacologic…

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Principal Investigator:
  • Deena Gendoo, The Hospital For Sick Children

Identification of Brain Metastasis Initiating Cells and Regulators of Brain Metastasis from Lung Cancer

Project Overview

Ms. Singh’s project investigates brain metastases (BMs) – the most frequent type of brain tumour to occur in adults. The specific goals of her project include functional characterization of BMIC regulatory genes using a new human-mouse BMIC xenograft model, predictive signatures for patients wit…

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Principal Investigator:
  • Mohini Singh, McMaster University

Nonlinear MR-US Registration for Image Guided Neurosurgery of Brain Tumours

Project Overview

Each year, thousands of Canadians undergo neurosurgery for the resection of cancerous lesions. Their survival rate is significantly increased when tumour resection is complete, and image–guided neurosurgery is an important tool to help surgeons accurately localize the lesions. However, the usefu…

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Principal Investigator:
  • Ian Gerard, McGill University

Role of YAP/Hippo and Wnt signaling in human gliomagenesis and glioma tumour-initiating cells

Project Overview

Dr. Katherine Rowland’s research project explores the dynamic relationship between CSCs and the wider cellular hierarchy in GBM as governed by the canonical Wnt/β-catenin (cWnt) signaling pathway. She aims to address the apparent dichotomy of whether endogenous cWnt signaling functions to promote…

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Principal Investigator:
  • Katherine Rowland, The Hospital For Sick Children

The Profile and Trajectory of Brain Tumours across the Continuum of Care in Ontario, Canada: A Population Based Study

Project Overview

The goal of Ms. Chan’s research project is to provide data on the healthcare use of patients with malignant and benign brain tumours. Specifically, the objectives of her project include:  (1) to identify the number of persons with a brain tumour in Ontario, (2) the demographic, clinical, and soci…

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Principal Investigator:
  • Vincy Chan, University of Toronto