Brain Canada Brain Canada
FR Donate

Our directory of funded grants

40 result(s) found

A Human System to study Immune-Ependymal Cell Relationships

Project Overview

Ependymal cells are a largely understudied barrier cell type in the brain that provide a wall between brain tissue and brain fluid (cerebral spinal fluid, CSF), playing an important role in regulating fluid balance. These cells become dysfunctional in many brain diseases and this dysfunction contrib…

See researchers on this project
Team Members:
  • Jo Anne Stratton, Montreal Neurological Institute, McGill University

Causal tests of the hippocampal circuits mediating neural and behavioral pattern completion

Project Overview

Most people have experienced the recollection of a vivid memory after encountering a trigger, such as a familiar place, object, or smell. In neuroscience, this process is called ‘pattern completion’. For years people have thought that a particular part of the brain, called the ‘trisynaptic cir…

See researchers on this project
Principal Investigator:
  • Mark Brandon,

    Douglas Hospital Research Centre

Challenging epigenetic hallmarks of aging in the choroid plexus to improve brain homeostasis

Project Overview

The choroid plexus (CP) is a secretory tissue found in each of the brain ventricles. The CP produces a clear fluid called cerebrospinal fluid (CSF) which helps to cushion the brain, to circulate nutrients, and remove waste from our brain. In addition, the CP secretes important molecules involved in …

See researchers on this project
Principal Investigator:
  • Benoit Laurent, Université de Sherbrooke

Circadian control of microglial activation in chronic pain states

Project Overview

Circadian, or 24-hour, rhythms control almost all biological systems in our bodies with sleep-wake cycles and body temperature control the best known examples. Interestingly, pain is also governed by these 24-hour rhythms. People suffering from chronic neuropathic pain have been found to rate their …

See researchers on this project
Principal Investigator:
  • Nader Ghasemlou, Queen's University

Closed-loop deep brain stimulation using chronic intracranial cortical sensing to inform subcortical stimulation delivery

Project Overview

Many patients with Parkinson’s disease experience freezing of gait (FoG), a debilitating symptom defined by “episodic absences or marked reduction of forward progression of the feet despite the intention to walk.” FoG can lead to reduced mobile independence and increased risk of falls, which c…

See researchers on this project
Principal Investigator:
  • Luka Milosevic, University Health Network

Defining the mechanism of inhibition of tau aggregation by the molecular chaperone, DNAJA2

Project Overview

Alzheimer’s Disease is a progressive and fatal disease that currently afflicts up to 400,000 Canadians over the age of 65. One key observation about this disease is that there is an abnormal “clumping” (aggregation) of specific proteins such as tau. Proteins normally need to keep a certain sha…

See researchers on this project
Principal Investigator:
  • Sue-Ann Mok, University of Alberta

Detection of tandem repeat expansion in neurological disorders

Project Overview

In the past decade, rapid development of software has allowed detection of a wide variety of genetic risk factors in brain disorders. It has improved clinical diagnosis and gene discovery for numerous human brain disorders. However, the casual genetic risk factors identified so far generally confer …

See researchers on this project
Principal Investigator:
  • Ryan Yuen, The Hospital for Sick Children

Direct microglial reprogramming to study Parkinson’s Disease

Project Overview

The human brain is a complex organ that presents many challenges for neuroscientists. For instance, tissue availability represents a major problem given that this organ does not regenerates, making it next to impossible to obtain live tissue from patients that would allow to study how cells in the b…

See researchers on this project
Principal Investigator:
  • Janelle Drouin-Ouellet, University of Montreal

Dopaminergic modulation of stroke recovery

Project Overview

Strokes often cause brain damage that affects normal cognitive and sensorimotor functions. The brain has the extraordinary ability to adapt by forming new circuits which can, to some extent, compensate for neuronal loss. The recovery of motor function can be improved by rehabilitation exercises aime…

See researchers on this project
Principal Investigator:
  • Christian Ethier, Université Laval

Evaluating therapeutic stimulation in a mouse model of perinatal stroke

Project Overview

Neonatal strokes occur in approximately 1 in 1500 term births and is the leading cause of hemiplegic cerebral palsy (HCP). The ischemic event leaves most children with life-long motor impairments, and in many cases the effects of rehabilitation are minimal. One potential mechanism for further enhanc…

See researchers on this project
Principal Investigator:
  • Greg Silasi, University of Ottawa

Evaluation of Long-Axis Hippocampal Subfield Volumetry as a neuroimaging biomarker for Alzheimer’s disease

Project Overview

The hippocampus is the brain region which shows the most severe changes in patients with Alzheimer’s disease. Magnetic resonance imaging can be used to measure these changes in order to improve diagnosis and evaluate potential treatment options for patients with Alzheimer’s disease. The hippoca…

See researchers on this project
Principal Investigator:
  • Trevor Steve, University of Alberta

Functional hyperalignment in pediatric fMRI

Project Overview

Brain scans from MRI machines are an important research tool for studying psychiatric and neurological disorders in children. MRI lets us study brain structure, and functional MRI (fMRI) lets us also study brain function. In fMRI, each child’s brain images need to be lined up in a special way so t…

See researchers on this project
Principal Investigator:
  • Tamara Vanderwal, University of British Columbia

Genetic and therapeutic dependencies in SHH driven childhood medulloblastoma

Project Overview

Medulloblastoma is the most common malignant brain tumour of childhood, affecting 60-80 Canadian children per year. The treatment for medulloblastoma comprises surgery, followed by radiation to the entire brain and spinal cord, and high doses of non-specific chemotherapy. Despite such aggressive tre…

See researchers on this project
Principal Investigator:
  • Vijay Ramaswamy, The Hospital for Sick Children

Identifying the cell-type specific transcriptional program by Npas4 in motor learning

Project Overview

The primary motor cortex in the brain is responsible for voluntary movement. It has also been proposed to be one of the sites for motor memory formation and storage. Therefore, when the motor cortex is damaged following a stroke, we lose the ability to execute movements that were formerly part of no…

See researchers on this project
Principal Investigator:
  • Simon Chen, University of Ottawa

Impact of brain trauma in childhood on white matter maturation

Project Overview

An enormous amount of brain development occurs throughout childhood and experiencing a concussion during this time may have long-lasting effects. An important part of brain development is the maturation of brain connectivity. Connections in the brain are made up of axons, the long thin projections o…

See researchers on this project
Principal Investigator:
  • Anne Wheeler, The Hospital for Sick Children

Impaired orexin activity as a mediator of isolation-induced social anxiety

Project Overview

We live in a world profoundly shaped by social behaviours involving interactions and communications between conspecifics of a given species. All mammals, ranging from primates to rodents, depend on each other to survive and reproduce. For children and young adults, neglect and being deprived of soci…

See researchers on this project
Principal Investigator:
  • Derya Sargin, University of Calgary

Individually Tailored Prediction of Treatments Response in Alzheimer’s Disease: 3 clinical trials validation

Project Overview

Late-onset Alzheimer’s (late-AD) is a complex neurodegenerative condition with abnormalities in toxic protein accumulation, vascularization, inflammation, neuronal activity and cerebral atrophy. In keeping with the tenets of Personalized Medicine, treatments should be tailored to individual therap…

See researchers on this project
Principal Investigator:
  • Yasser Iturria Medina, McGill University

Investigating altered functional brain networks in autism spectrum disorder

Project Overview

Autism Spectrum Disorder (ASD) is a complex developmental brain disorder characterised by impaired communication and repetitive behaviors, and is often accompanied by intellectual disability. According to the Public Health Agency of Canada, 1 in 66 children and youth in Canada is diagnosed with ASD.…

See researchers on this project
Principal Investigator:
  • Allen Chan, University of Alberta

Investigating mechanisms that cause mitochondrial dysfunction and synaptic loss

Project Overview

Amyotrophic lateral sclerosis (ALS) is a fatal disease involving the gradual death of motor neurons. Motor neurons control the body’s movement. As such, their loss leads to muscle weakness, paralysis, and eventually death. Unfortunately, there is no cure or treatments for those living with ALS, in…

See researchers on this project
Principal Investigator:
  • Chantelle Sephton, Université Laval

Investigating Spike-Timing Dependent Plasticity Mechanisms of Memory Consolidation with Multiscale Hippocampal-Cortical Modelling

Project Overview

The formation of our memories is a behaviour that encapsulates both long-and-short time scales. On the short time-scale, memories are initially formed in the hippocampus through the sequential firing of neurons. These sequences are then replayed by the hippocampus during sleep, where they are though…

See researchers on this project
Principal Investigator:
  • Wilten Nicola, University of Calgary