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Our directory of funded grants

9 result(s) found

Advanced multi-functional in vivo retinal imaging for ocular oncology

Project Overview

Need for project: Choroidal tumors present clinicians with many challenges. The overlap between clinical and imaging findings combined with the difficulty of performing choroidal biopsies can create diagnostic dilemmas. Obtaining a diagnosis is paramount in optimizing patient outcomes, minimizing sy…

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Principal Investigator:
  • Zaid Mammo, University of British Columbia
Team Members:
  • Myeong Jin Ju, University of British Columbia
  • Katherine Paton, BC Cancer Agency
  • Marinko Sarunic, Simon Fraser University

Detection and prevention of pypermutant glioma in children and young adults

Project Overview

Need for project: Replication repair deficiency (RRD) is a genetic condition that significantly increases the risk of developing cancer, particularly early in life. Gliomas are the most common brain tumour seen in children and young adults (CAYA), and occur frequently in RRD. Currently, the prevalen…

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Principal Investigator:
  • Uri Tabori, The Hospital For Sick Children
Team Members:
  • Cynthia Hawkins, The Hospital For Sick Children
  • Jane Barron, Memorial University
  • Sunit Das, St. Michael's Hospital
  • Sidney E. Croul, Dalhousie University
  • Birgit Ertl-Wagner, The Hospital for Sick Children
  • Andrew Gao, University Health Network
  • Normand J Laperriere, Princess Margaret Cancer Centre
  • Julia Keith, Sunnybrook Health Sciences Centre
  • Farzad Khalvati, The Hospital for Sick Children
  • Derek Tsang, Princess Margaret Cancer Centre - UHN

Early detection and novel stratification of pediatric low-grade gliomas by MRI-based artificial intelligence

Project Overview

Need for project: Pediatric low-grade glioma (pLGG) is the most common pediatric brain tumour and affected children suffer from multiple recurrences. Recently, genetic markers of pLGG have shown potential for improved diagnosis and prognosis. The genetic profile of pLGG is assessed through biopsy. T…

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Principal Investigator:
  • Farzad Khalvati, The Hospital for Sick Children
Team Members:
  • Eric Bouffet, The Hospital for Sick Children
  • Cynthia Hawkins, The Hospital For Sick Children
  • Birgit Ertl-Wagner, The Hospital for Sick Children
  • Uri Tabori, The Hospital For Sick Children

Early diagnosis of gliomas by using a novel multiplexed serum proteomic technology

Project Overview

Need for project: Gliomas are among the most malignant tumors, with very poor survival rates. Early diagnosis is highly desirable since it can facilitate more effective treatments of small tumors, which have not as yet extensively metastasized. It is thus of upmost importance to find non-invasive bi…

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Principal Investigator:
  • Eleftherios Diamandis, Lunenfeld-Tanenbaum Research Institute
Team Members:
  • Douglas Fraser, Children’s Health Research Institute
  • Maxime Richer, Université de Sherbrooke

Physical fingerprints of single extracellular vesicles for liquid biopsy in brain cancer

Project Overview

Need for project: Glioblastoma (GBM) is an incurable brain cancer that changes rapidly confounding standard diagnostic and therapeutic methods. These changes in molecular composition can be captured by bits of cancer cells known as extracellular vesicles (EVs) found in blood of patients (liquid biop…

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Principal Investigator:
  • Sara Mahshid, McGill University
Team Members:
  • Janusz Rak, The Research Institute of the McGill University Health Centre
  • Walter Reisner, McGill University
  • Sebastian Wachsmann-Hogiu, McGill University
  • Kevin Petrecca, McGill University

Precision diagnosis and prognosis of primary and metastatic brain tumours using DNA methylation profiling in liquid biopsy

Project Overview

Need for project: More sensitive molecular tools are needed in the field of neuro-oncology to enable early detection, more accurate diagnosis, and prediction of outcome for brain tumors. We have early experience in establishing that DNA methylome signatures in liquid biopsy can be used as a highly s…

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Principal Investigator:
  • Gelareh Zadeh, University Health Network, Princess Margaret, University of Toronto
Team Members:
  • Kenneth Aldape, Princess Margaret Centre - UHN
  • Daniel De Carvalho, Princess Margaret center - UHN

Radiomics and machine learning based non-invasive biomarkers for prediction of peritumoral invasion in brain metastases

Project Overview

Need for project: Treatment of brain metastases (BrM) includes a combination of surgery and radiation therapy (RT). Recurrence after treatment is a problem that limits survival and quality of life. Our team has discovered that highly invasive growth of BrM is associated with recurrence and sensitivi…

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Principal Investigator:
  • Reza Forghani, McGill University
Team Members:
  • Marie-Christine Guiot, Montreal Neurological Hospital and Institute
  • Stephanie Lam, Montreal Neurological Institute
  • Laurent Létourneau-Guillon, Centre hospitalier de l'université de Montréal(CHUM)
  • Kevin Petrecca, McGill University
  • Peter Siegel, McGill University

Safety and feasibility of focused ultrasound-enabled liquid biopsy in patients with brain tumours

Project Overview

Need for project: Neuropathological diagnoses of brain tumours require invasive neurosurgical biopsies that carry a risk of morbidity or mortalityto patients. There has been growing interest in the use of non-invasive liquid biopsies to sample cell-free circulating tumorDNA (ctDNA) for genomic and e…

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Principal Investigator:
  • Andres Lozano, University Health Network
Team Members:
  • Daniel De Carvalho, Princess Margaret center - UHN
  • Gelareh Zadeh, University Health Network, Princess Margaret, University of Toronto

Screening of glioblastoma oncometabolite by ultrafast solid phase microextraction approach

Project Overview

Need for project: The rate of success of a given treatment for brain cancer is dependent on early diagnosis followed by qualification for surgery, which to date remains as the course of treatment with the highest survival rate for brain cancer patients. In this regard, a fast and reliable population…

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Principal Investigator:
  • Janusz Pawliszyn, University of Waterloo