Directory of funded grants

Neural indices of a modified auditory oddball task and their symptom correlates in post-traumatic stress disorder dissociative vs. non-dissociative subtypes

Project Overview

Dr. Hubert van Tol Travel Fellowship Individuals with post-traumatic stress disorder (PTSD) may experience differences in discriminating between and paying attention to certain types of sounds. These differences can be measured using brain electrical activity. Previous work has shown that PTSD is associated with reductions in the magnitude of response…

The dark microglial subset displays ultrastructural and metabolic alterations in an aged mouse model of beta-amyloid pathology

Project Overview

Dr. Hubert van Tol Travel Fellowship AIMS: Recent technical advances helped to reveal the considerable heterogeneity of microglia, the resident immune cells of the central nervous system. One of these microglial subsets, the dark microglia (DM), was characterized by ultrastructural signs of cellular stress such as dilated endoplasmic reticulum (ER),…

Sedation and Cerebral Oximetry in Traumatic Brain Injury: A Potentially Non-invasive Avenue for Personalized Approaches in Neurocritical Care?

Effects of Sex and Age on Nicotine Vapour Reward, Withdrawal, Pharmacokinetics, and Brain Activity

Project Overview

Dr. Hubert van Tol Travel Fellowship The landscape of nicotine use has seen drastic change in recent years, with steady declines in cigarette smoking and dramatic increases in nicotine vaping. Though vaping likely represents a safer alternative to smoking, there are many unknowns regarding its efficacy as a tobacco replacement…

Evaluating the frequency and impact of structural variation in amyotrophic lateral sclerosis (ALS)

Project Overview

Dr. Hubert van Tol Travel Fellowship Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that lacks treatment options, and much remains to be understood regarding an individual’s genetic susceptibility to the disease. Recently, we were able to use large DNA sequencing datasets to determine that ALS cases carry an…