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519 results found

Disrupting VCP/p97-GluA1 as a novel therapeutic intervention to restore synaptic plasticity in Alzheimer’s disease: A cryo-electron microscopy (cryo-EM) based approach

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer Society Research Program (ASRP)

  • Province

    British Columbia

  • Start Date

    2023

  • Total Grant Amount

    $100,000

Project Overview

Many proteins in our brain are responsible for memory and learning. These proteins frequently come together to form larger complexes. This study will explore the molecular structure of these complexes to find areas where drugs can attach and rescue diseased cells. Once these areas are located, various drugs will be…

Project Ongoing

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Amyloid deposition and the glymphatic system assessed simultaneously in Alzheimer’s disease using PET/MRI

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer Society Research Program (ASRP)

  • Province

    Ontario

  • Start Date

    2023

  • Total Grant Amount

    $100,000

Project Overview

Poor sleep is a known risk factor for Alzheimer’s disease. This is likely due to sleep’s role in removing waste products from the brain. There is currently no way to view this waste removal process without posing a risk to the individual, but new approaches using medical imagining technologies may…

Project Ongoing

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Quantitative fluorescence spectroscopy of the central nervous system amylome

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer Society Research Program (ASRP)

  • Province

    Alberta

  • Start Date

    2023

  • Total Grant Amount

    $100,000

Project Overview

It is generally acknowledged that accumulation of misfolded proteins (amyloid) in brains of Alzheimer’s disease patients is a key disease phenomenon. But not all amyloids cause disease, and those that do come in many different varieties. Currently, there is a lack of good ways to assess the misfolded character of…

Project Ongoing

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Control of mRNA translation in Microglia response to Alzheimer’s disease pathology

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer Society Research Program (ASRP)

  • Province

    Québec

  • Start Date

    2023

  • Total Grant Amount

    $100,000

Project Overview

Microglia are the brain’s immune cells, and their role is to protect the brain. Yet in Alzheimer’s disease, these cells are often found diseased as well. In a brain with Alzheimer’s disease, the microglia’s ability to provide instruction is defective. This study’s hypothesis is that restoring translation on microglia will…

Project Ongoing

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Alternative Strategies to Prevent Oral Pathogens Infection and Battle Alzheimer’s Disease

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer Society Research Program (ASRP)

  • Province

    Québec

  • Start Date

    2023

  • Total Grant Amount

    $200,000

Project Overview

Bacteria involved in gum disease can be found in the brains of people with Alzheimer’s disease and dementia. These bacteria help release toxins into different tissues, including the brain. And these toxins, in turn, increase amyloid beta in the brain, contributing to Alzheimer’s disease. This study will explore how gum-disease…

Project Ongoing

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