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Our directory of funded grants

224 result(s) found

Validation of Connexins and Pannexins as a target for Alzheimer’s Disease

Project Overview

Alzheimer’s Disease (AD) is the most common cause of dementia, accounting for over two thirds of cases. As of 2013, there are over 44 million people with dementia worldwide. This number is estimated to increase to over 75 million in 2030; 1.4 million of these will be in Canada. Today, the combined…

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Principal Investigator:
  • Christian Naus, University of British Columbia
Team Members:
  • Weihong Song, University of British Columbia
  • Juan Saez, Pontificia Universidad Católica de Chile
  • Christian Giaume, Collège de France
  • Luc Leybaert, Ghent University

Validation of ocular measures as potential biomarkers for early detection of brain amyloid and neurodegeneration

Project Overview

500,000 Canadians have dementia, a number that will double within a generation due to the ongoing aging demographics of the population, with annual costs estimated to increase from $15B currently to over $150B by the year 2050. The estimated total cost to the society including the loss of productivi…

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Principal Investigator:
  • Sandra Black, Sunnybrook Health Sciences Centre
Team Members:
  • Anthony Lang, Krembil Research Institute
  • Chris Hudson , University of Waterloo
  • Lee Goldstein, Boston University
  • Barry Greenberg, Krembil Research Institute
  • Efrem Mandelcorn, Krembil Research Institute
  • Edward Margolin, Krembil Research Institute
  • Stephen Strother, Rotman Research Institute
  • Aristotle Voineskos, Centre for Addiction and Mental Health

Wnt Signalling Circuits in Glioma Progression

Project Overview

The goal of Ms. Rajakulendran’s project is to characterize the role of Wnt signalling in glioma progression. The primary objective is to determine whether glioblastoma multiforme (GBM) is dependent on Wnt signalling for cancer stem cell self-renewal. The secondary objective is to identify the Wnt …

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Principal Investigator:
  • Nishani Rajakulendran, University of Toronto

Z-BRAIN: A Zebrafish Drug Screening Platform Targeting Brain Disorders

Project Overview

The traditional target-based drug development strategy (in vitro screening) has had poor success in developing new drugs. The vast majority of Investigational New Drugs (INDs) fail in clinical trials due to toxicity or lack of efficacy. On the other hand, mammalian models are excellent tools to stud…

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Principal Investigator:
  • Xiao-Yan Wen, St. Michael's Hospital
Team Members:
  • Pierre Drapeau, CHUM Research Centre, University of Montréal
  • Raymond Andersen, University of British Columbia
  • Robert Gerlai, University of Toronto
  • Georg Zoidl, York University
  • Loch Macdonald, St. Michael's Hospital
  • Andrew Baker, St. Michael's Hospital
  • Albert Wong, Centre for Addiction and Mental Health
  • Marc Ekker, University of Ottawa
  • Sidney H. Kennedy, University Health Network
  • Alan Fine, Dalhousie University
  • Janice Robertson, University of Toronto
  • Vince Tropepe, University of Toronto
  • Henry Krause, University of Toronto
  • Terry Van Raay, University of Guelph
  • Tom Schweizer, St. Michael's Hospital
  • David Munoz, St. Michael's Hospital
  • Corinne Fischer, St. Michael's Hospital
  • Thomas Steeve, St. Michael's Hospital
  • Ted Allison, University of Alberta
  • Cheryl Gregory-Evans, University of British Columbia
  • Claudia dos Santos, St. Michael's Hospital