Directory of funded grants

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774 results found

A patient-derived iPSC platform of disease relevant cell models for biological studies

  • Grant Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Arthur J. Hudson Translational Team Grant

  • Province

    Québec

  • Start Date

    2017

  • Total Grant Amount

    $2,203,120

  • Health Canada Contribution

    $1,101,560

Project Overview

One of the greatest advancements in science over the past 10 years is the development of induced pluripotent stem cells (iPSCs). These cells make it possible to create essentially any cell type in the body using any other as a starting point. In ALS, iPSCs provide the opportunity to take…

Project Ongoing

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Decoding motor cortex circuit abnormalities at ALS onset through combined two-photon imaging in vivo and pharmacogenetics

  • Grant Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2017

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

ALS is a disease that is characterized by degeneration of both upper and lower motor neurons, and while a significant proportion of work has focused on motor neurons in the spinal cord, the motor cortex in the brain, where electrical signals to your muscles originate have clear, but poorly understood…

Project Complete

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Investigation of microbiota mediated suppression of motor neuron degeneration in genetic models of ALS

  • Grant Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2017

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

Scientists have long wondered what the contribution of environment is to ALS and in recent years the idea that a combination of genetic susceptibility and environmental triggers has taken shape. Furthermore, one of the emerging areas of interest for environmental exposure is the gastrointestinal tract and how dietary exposures might…

Project Complete

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Proteomic and Transcriptomic Profiling of Paraspeckle Function in Healthy and ALS Model Neuronal Cells

  • Grant Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2017

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

Over the past decade, the number of new cellular structures that have been identified with critical functions for life has expanded considerably. One of the more recent discoveries is a structure called a paraspeckle, which remains poorly understood but also has multiple components that have been identified as proteins that…

Project Complete

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Defining conserved functions of RNA binding proteins in stress-granule biogenesis

  • Grant Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2017

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

RNA is a mobile form of genetic information that is made from our DNA and its complex regulation is extremely important to the proper functioning of our cells. Since the discovery of TDP-43 in 2006 as a substance that plays a major role in ALS, the hypothesis that abnormal regulation…

Project Complete

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