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Our directory of funded grants

334 result(s) found

Screening of glioblastoma oncometabolite by ultrafast solid phase microextraction approach

Project Overview

Need for project: The rate of success of a given treatment for brain cancer is dependent on early diagnosis followed by qualification for surgery, which to date remains as the course of treatment with the highest survival rate for brain cancer patients. In this regard, a fast and reliable population…

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Principal Investigator:
  • Janusz Pawliszyn, University of Waterloo

Season, Light Exposure and Serotonin Transporter Binding

Project Overview

In this study, Ms. Tyrer examined the role of the brain protein, serotonin transporter (5-HTT), and its role in Seasonal Affective Disorder (SAD). 5-HTT is a brain protein that clears serotonin from synapses, and serotonin depletion has been associated with low mood. Ms. Tyrer utilized a type of pos…

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Principal Investigator:
  • Andrea Tyrer, Centre for Addiction and Mental Health

Selective knockdown of misfolded SOD1 as a therapy for amyotrophic lateral sclerosis

Project Overview

In some cases of ALS, it is clear that specific inherited genetic changes (called mutations) can not only cause the disease, but can do so by creating a protein (the end product of genes that actually does a function in our cells) that has an abnormal, toxic function resulting in motor neuron degene…

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Principal Investigator:
  • Jiming Kong, University of Manitoba
Team Members:
  • Xinmin Li, University of Alberta
  • Hassan Marzban, University of Manitoba
  • Yu Tian Wang, University of British Columbia
  • Michael Namaka, University of Manitoba

Sex differences in exercise efficacy: Possible role of BDNF and stress axis

Project Overview

Research suggests that exercise can help improve brain health and decrease the risk of dementia, but there is variation in the benefit of different exercise interventions. Cindy Barha, Ph.D. and colleagues hypothesize that male and female brains may respond in different ways to different types of ex…

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Principal Investigator:
  • Cindy Barha, University of British Columbia

ShARP: Screenable assays for RNA-binding proteins involved in brain disorders and diseases

Project Overview

Brain disorders such as autism, major depressive disorder and Alzheimer’s disease are among the greatest medical challenges of our era. Many drugs targeting the central nervous system (CNS) have been developed to modulate G protein-coupled receptors, ion channels or transporters with mitigated suc…

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Principal Investigator:
  • Martin Beaulieu, University of Toronto

SLAP-CAN In vivo Imaging Facility

Project Overview

The central nervous system (CNS, the brain and spinal cord together) is perhaps the most complex biological entity in the world. The CNS allows us to experience our environment, to feel pleasure and pain, and to remember events that take place in our lives. Understanding how the CNS works is the bro…

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Principal Investigator:
  • Sheena Josselyn, The Hospital For Sick Children
Team Members:
  • Paul Frankland, The Hospital For Sick Children
  • Michael Salter, The Hospital for Sick Children
  • Kaspar Podgorski,

    Janelia

Sleep, cognition, and inflammation following natural or surgical menopause

Project Overview

Alzheimer’s disease disproportionately affects women and emerging evidence suggests there may be unique biological and lifestyle factors that underlie these differences. A woman’s brain health, for example, may be affected more strongly than a man’s by the presence of APOE-e4, a gene variant l…

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Principal Investigator:
  • Nicole Gervais, University of Toronto

Social determinants of prevalence, health service use, and developmental outcomes of children with Autism Spectrum Disorder: A population-level study

Project Overview

This project is examining the relationship between neighbourhood socioeconomic disadvantage with prevalence, health service use, and developmental outcomes of children with Autism Spectrum Disorder (ASD). Research shows that health is unevenly distributed across socioeconomic status (SES) – those …

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Principal Investigator:
  • Ayesha Siddiqua,

    MacMaster University

Solid phase microextraction-based integrated platform for untargeted and targeted in vivo brain studies

Project Overview

This project proposes to integrate the low-invasive, non-lethal in vivo sampling/sample preparation SPME approach with MS detection to obtain the full profile of brain metabolome and lipidome, the quantification of drugs and monitoring of their metabolism, selective extraction of target compounds (d…

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Principal Investigator:
  • Janusz Pawliszyn, University of Waterloo
Team Members:
  • Dajana Vuckovic, Concordia University 
  • Clement Hamani, Centre for Addiction and Mental Health

Stimulating Endogenous Regeneration of Photoreceptors as a Potential Cure for Blindness

Project Overview

Sight is the most precious sense, and patients suffering vision loss endure a devastating experience. Blindness often results from the gradual death of photoreceptors, the retinal cells that perceive light. Many researchers are attempting to replace lost cells through transplantation of stem cell-de…

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Principal Investigator:
  • Rod Bremner, LTRI Sinai Health System, University of Toronto
Team Members:
  • Donald Weaver, Toronto Western Research Institute, University of Toronto
  • Michel Cayouette, Institut de Recherches Cliniques de Montréal, Université de Montréal
  • Gautam Awatramani, University of Victoria
  • Philippe Monnier, Toronto Western Research Institute, University of Toronto

Strains of A-beta aggregates in Alzheimer’s disease

Project Overview

The existence of different strains of misshapen proteins in the brains of Alzheimer’s disease (AD) patients is emerging as an obstacle to the development of effective treatments. Recent research has revealed that the proteins that accumulate in the brain during AD are reminiscent of prions, which …

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Principal Investigator:
  • Joel Watts,

    University of Toronto

Stroke Recovery in Motion

Project Overview

One in six people worldwide will experience a stroke in their lifetime. One third of these people are left permanently disabled. In 2013, at least 405,000 Canadians were living with long-term stroke disability and this number is projected to increase to 726,000 over the next 20 years. Advances in ac…

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Principal Investigator:
  • Ian Graham, University of Ottawa
Team Members:
  • Mark Bayley, Toronto Rehabilitation Institute
  • Marie-Louise Bird, University of Tasmania
  • Janice Eng, University of British Columbia
  • Michelle Nelson, Lunenfeld-Tanenbaum Research Institute
  • Michelle Ploughman, Memorial University of Newfoundland
  • Justin Presseau, Ottawa Hospital Research Institute, University of Ottawa
  • Julia Richardson, McMaster University
  • Nancy Salbach, University of Toronto
  • Sharon Straus, St. Michael's Hospital
  • Ada Tang, McMaster University
  • Robert Teasell, Parkwood Institute

Structural and functional networks in Autism Spectrum Disorder and Fragile X Syndrome

Project Overview

Many childhood disorders, such as Autism Spectrum Disorder (ASD) or Fragile X Syndrome (FXS), are a result of abnormal growth and connections throughout the brain, rather than being caused by some specific pathology, such as a tumour. For meaningful diagnosis, prognosis and intervention for these de…

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Principal Investigator:
  • Alan Evans, Montreal Neurological Institute and Hospital, McGill University
Team Members:
  • Lonnie Zwaigenbaum, University of Alberta
  • Louis Collins, McGill University
  • Pierre Bellec , Université de Montreal 
  • Mayada Elsabbagh, McGill University
  • Sherif Karama, McGill University
  • Joseph Piven, University of North Carolina at Chapel Hill 
  • Heather Cody Hazlett, University of North Carolina at Chapel Hill 
  • John Pruett, Washington University in St. Louis
  • Kelly Botteron, Washington University in St. Louis

Study of the impact of glycation on ALS using an in vitro tissue-engineered model of spinal cord

Project Overview

Tissue engineering is a process that was originally designed and continues to be used for growing cells outside the body, turning them into functional tissues and organs, and applying them for clinical use. Skin grafting and developing new organs for transplant are examples of how tissue engineering…

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Principal Investigator:
  • François Berthod, CRCHUQ, Enfant-Jesus, University Laval

Summer School in Computational Sensory Motor Neuroscience (CoSMo)

Project Overview

Major breakthroughs in neuroscience have been achieved through the application of computational models to empirical research. Models are essential to connect theory to behavior and the increasingly rich and complex measures of nervous function at multiple spatial and temporal scales. That said, mode…

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Team Members:
  • Gunnar Blohm, Queen's University

Synaptic inhibition in the motor cortex of an ALS mouse model

Project Overview

ALS is a disease characterized by degeneration of both upper and lower motor neurons. Upper motor neurons are located in a region of the brain called the motor cortex and have been far less extensively studied than lower motor neurons in the spinal cord. One of the earliest detectable abnormalities …

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Principal Investigator:
  • Melanie Woodin, University of Toronto

Synaptic mechanisms in post-stroke depression

Project Overview

Stroke affects 17% of people worldwide and some estimates predict that it will soon become the most common cause of death worldwide. Post-stroke depression impacts a significant portion of patients that suffered from a stroke. The consequences of post-stroke are immense and are a severe impairment i…

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Principal Investigator:
  • Jean-Claude Béïque, University of Ottawa

Synergistic combination of IAP antagonism and immunotherapy to treat brain cancers

Project Overview

Brain cancers can be exceptionally challenging to treat, and new therapies are needed. Cancer cells can resist treatment in part through proteins that protect cells from dying called IAPs. Dr Robert Korneluk has found that combining IAP-blocking drugs with immunotherapy can kill cancer cells very ef…

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Principal Investigator:
  • Robert Korneluk, University of Ottawa/CHEO

Systematic assessment of retinal output following optogenetic vision therapy

Project Overview

Optogenetic strategies – the ability to activate normally light-insensitive neurons with light – are being used in clinical trials to restore light sensitivity to the retina of vision impaired patients. In normally sighted individuals, before visual signals reach the brain, the retina uses its c…

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Principal Investigator:
  • Stuart Trenholm, McGill University