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Our directory of funded grants

366 result(s) found

Role of mitochondrial c-Src kinase in Alzheimer’s disease

Project Overview

Mitochondrial dysfunctions are observed before and during the progression of Alzheimer’s disease (AD). It is important to understand how the regulation of mitochondria is impaired in AD. The c-Src kinase has appeared as an important regulator of mitochondria. The aim of this research program is to…

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Principal Investigator:
  • Etienne Hebert-Chatelain, Université de Moncton

Role of YAP/Hippo and Wnt signaling in human gliomagenesis and glioma tumour-initiating cells

Project Overview

Dr. Katherine Rowland’s research project explores the dynamic relationship between CSCs and the wider cellular hierarchy in GBM as governed by the canonical Wnt/β-catenin (cWnt) signaling pathway. She aims to address the apparent dichotomy of whether endogenous cWnt signaling functions to promote…

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Principal Investigator:
  • Katherine Rowland, The Hospital For Sick Children

Safety and feasibility of focused ultrasound-enabled liquid biopsy in patients with brain tumours

Project Overview

Need for project: Neuropathological diagnoses of brain tumours require invasive neurosurgical biopsies that carry a risk of morbidity or mortalityto patients. There has been growing interest in the use of non-invasive liquid biopsies to sample cell-free circulating tumorDNA (ctDNA) for genomic and e…

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Principal Investigator:
  • Andres Lozano, University Health Network
Team Members:
  • Daniel De Carvalho, Princess Margaret center - UHN
  • Gelareh Zadeh, University Health Network, Princess Margaret, University of Toronto

Screening of glioblastoma oncometabolite by ultrafast solid phase microextraction approach

Project Overview

Need for project: The rate of success of a given treatment for brain cancer is dependent on early diagnosis followed by qualification for surgery, which to date remains as the course of treatment with the highest survival rate for brain cancer patients. In this regard, a fast and reliable population…

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Principal Investigator:
  • Janusz Pawliszyn, University of Waterloo

Season, Light Exposure and Serotonin Transporter Binding

Project Overview

In this study, Ms. Tyrer examined the role of the brain protein, serotonin transporter (5-HTT), and its role in Seasonal Affective Disorder (SAD). 5-HTT is a brain protein that clears serotonin from synapses, and serotonin depletion has been associated with low mood. Ms. Tyrer utilized a type of pos…

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Principal Investigator:
  • Andrea Tyrer, Centre for Addiction and Mental Health

Selective knockdown of misfolded SOD1 as a therapy for amyotrophic lateral sclerosis

Project Overview

In some cases of ALS, it is clear that specific inherited genetic changes (called mutations) can not only cause the disease, but can do so by creating a protein (the end product of genes that actually does a function in our cells) that has an abnormal, toxic function resulting in motor neuron degene…

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Principal Investigator:
  • Jiming Kong, University of Manitoba
Team Members:
  • Xinmin Li, University of Alberta
  • Hassan Marzban, University of Manitoba
  • Yu Tian Wang, University of British Columbia
  • Michael Namaka, University of Manitoba

Serotonin circuit dysregulation in Alzheimer’s Disease

Project Overview

Alzheimer’s Association International Research Grant Program: Alzheimer’s Association Research Grant (AARG) Today, more than six million people in North America are living with dementia, with an estimated annual economic burden of $150 billion for patients and caregivers. Alzheimer’s Disease (…

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Principal Investigator:
  • Derya Sargin, University of Calgary

Sex differences in exercise efficacy: Possible role of BDNF and stress axis

Project Overview

Research suggests that exercise can help improve brain health and decrease the risk of dementia, but there is variation in the benefit of different exercise interventions. Cindy Barha, Ph.D. and colleagues hypothesize that male and female brains may respond in different ways to different types of ex…

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Principal Investigator:
  • Cindy Barha, University of British Columbia

Sex differences in the innate immune response associated with Parkinson’s Disease

Project Overview

Age is the most important risk factor for Parkinson’s Disease (PD), followed by sex, with a higher risk in males. Studies show that brain inflammation occurs early in the disease and persists throughout its course. As such, inflammation is likely to contribute to the disease. In the brain, the mai…

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Principal Investigator:
  • Janelle Drouin-Ouellet, University of Montreal

Sex-Differences in Dopaminergic Regulation of Stroke Recovery in Rats

Project Overview

Strokes often cause brain damage that can severely affect motor function, particularly fine movements of the hands and digits. The motor cortex is the main brain area issuing commands for voluntary hand movements. This brain area, when damaged by a stroke, has the ability to adapt by forming new con…

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Principal Investigator:
  • Christian Ethier, Université Laval
Team Members:
  • Martin Lévesque, Université Laval
  • Zohreh Vaziri, Université Laval 
  • Janaki Raghavan, Université Laval

ShARP: Screenable assays for RNA-binding proteins involved in brain disorders and diseases

Project Overview

Brain disorders such as autism, major depressive disorder and Alzheimer’s disease are among the greatest medical challenges of our era. Many drugs targeting the central nervous system (CNS) have been developed to modulate G protein-coupled receptors, ion channels or transporters with mitigated suc…

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Principal Investigator:
  • Martin Beaulieu, University of Toronto

SLAP-CAN In vivo Imaging Facility

Project Overview

The central nervous system (CNS, the brain and spinal cord together) is perhaps the most complex biological entity in the world. The CNS allows us to experience our environment, to feel pleasure and pain, and to remember events that take place in our lives. Understanding how the CNS works is the bro…

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Principal Investigator:
  • Sheena Josselyn, The Hospital For Sick Children
Team Members:
  • Paul Frankland, The Hospital For Sick Children
  • Michael Salter, The Hospital for Sick Children
  • Kaspar Podgorski,

    Janelia

Sleep, cognition, and inflammation following natural or surgical menopause

Project Overview

Alzheimer’s disease disproportionately affects women and emerging evidence suggests there may be unique biological and lifestyle factors that underlie these differences. A woman’s brain health, for example, may be affected more strongly than a man’s by the presence of APOE-e4, a gene variant l…

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Principal Investigator:
  • Nicole Gervais, University of Toronto

Social connection in long-term care home residents

Project Overview

This proposal aims to further the health and care of people living in long-term care (LTC) homes by improving the measurement of social connection. We will systematically appraise existing measures of social connection used in research in this population, including objective (e.g., social isolation)…

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Principal Investigator:
  • Jennifer Bethell, University Health Network
  • Andrew Sommerlad, University College London

Social determinants of prevalence, health service use, and developmental outcomes of children with Autism Spectrum Disorder: A population-level study

Project Overview

This project is examining the relationship between neighbourhood socioeconomic disadvantage with prevalence, health service use, and developmental outcomes of children with Autism Spectrum Disorder (ASD). Research shows that health is unevenly distributed across socioeconomic status (SES) – those …

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Principal Investigator:
  • Ayesha Siddiqua,

    MacMaster University

Solid phase microextraction-based integrated platform for untargeted and targeted in vivo brain studies

Project Overview

This project proposes to integrate the low-invasive, non-lethal in vivo sampling/sample preparation SPME approach with MS detection to obtain the full profile of brain metabolome and lipidome, the quantification of drugs and monitoring of their metabolism, selective extraction of target compounds (d…

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Principal Investigator:
  • Janusz Pawliszyn, University of Waterloo
Team Members:
  • Dajana Vuckovic, Concordia University 
  • Clement Hamani, Centre for Addiction and Mental Health

Stimulating Endogenous Regeneration of Photoreceptors as a Potential Cure for Blindness

Project Overview

Sight is the most precious sense, and patients suffering vision loss endure a devastating experience. Blindness often results from the gradual death of photoreceptors, the retinal cells that perceive light. Many researchers are attempting to replace lost cells through transplantation of stem cell-de…

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Principal Investigator:
  • Rod Bremner, LTRI Sinai Health System, University of Toronto
Team Members:
  • Donald Weaver, Toronto Western Research Institute, University of Toronto
  • Michel Cayouette, Institut de Recherches Cliniques de Montréal, Université de Montréal
  • Gautam Awatramani, University of Victoria
  • Philippe Monnier, Toronto Western Research Institute, University of Toronto

Strains of A-beta aggregates in Alzheimer’s disease

Project Overview

The existence of different strains of misshapen proteins in the brains of Alzheimer’s disease (AD) patients is emerging as an obstacle to the development of effective treatments. Recent research has revealed that the proteins that accumulate in the brain during AD are reminiscent of prions, which …

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Principal Investigator:
  • Joel Watts,

    University of Toronto

Stroke Recovery in Motion

Project Overview

One in six people worldwide will experience a stroke in their lifetime. One third of these people are left permanently disabled. In 2013, at least 405,000 Canadians were living with long-term stroke disability and this number is projected to increase to 726,000 over the next 20 years. Advances in ac…

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Principal Investigator:
  • Ian Graham, University of Ottawa
Team Members:
  • Mark Bayley, Toronto Rehabilitation Institute
  • Marie-Louise Bird, University of Tasmania
  • Janice Eng, University of British Columbia
  • Michelle Nelson, Lunenfeld-Tanenbaum Research Institute
  • Michelle Ploughman, Memorial University of Newfoundland
  • Justin Presseau, Ottawa Hospital Research Institute, University of Ottawa
  • Julia Richardson, McMaster University
  • Nancy Salbach, University of Toronto
  • Sharon Straus, St. Michael's Hospital
  • Ada Tang, McMaster University
  • Robert Teasell, Parkwood Institute

Structural and functional networks in Autism Spectrum Disorder and Fragile X Syndrome

Project Overview

Many childhood disorders, such as Autism Spectrum Disorder (ASD) or Fragile X Syndrome (FXS), are a result of abnormal growth and connections throughout the brain, rather than being caused by some specific pathology, such as a tumour. For meaningful diagnosis, prognosis and intervention for these de…

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Principal Investigator:
  • Alan Evans, Montreal Neurological Institute and Hospital, McGill University
Team Members:
  • Lonnie Zwaigenbaum, University of Alberta
  • Louis Collins, McGill University
  • Pierre Bellec , Université de Montreal 
  • Mayada Elsabbagh, McGill University
  • Sherif Karama, McGill University
  • Joseph Piven, University of North Carolina at Chapel Hill 
  • Heather Cody Hazlett, University of North Carolina at Chapel Hill 
  • John Pruett, Washington University in St. Louis
  • Kelly Botteron, Washington University in St. Louis