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Our directory of funded grants

334 result(s) found

Tanycytic structural plasticity in circumventricular organs underlies homeostatic brain-body communication

Project Overview

Metabolic syndrome is a group of risk factors (obesity, hypertension, high fasting blood sugar, and high levels of triglycerides) that increase the risk of type 2 diabetes and cardiovascular diseases. Over 20% of adult Canadians suffer from metabolic syndrome (40% in adults over 60 years old), and e…

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Principal Investigator:
  • Masha Prager-Khoutorsky,

    McGill University

Targeting Amyloid Propagation in Alzheimer Disease: Structures, Immunology and Extracellular Vesicle Topology

Project Overview

A treatment or prevention of Alzheimer’s disease is a top priority for medical science. Small aggregates of the protein amyloid-beta (A-beta), called oligomers, have been identified as being the primary cause of brain cell death in Alzheimer’s disease. However, there are many different subtypes …

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Principal Investigator:
  • Neil Cashman, University of British Columbia
Team Members:
  • Cheryl Wellington, University of British Columbia
  • Ging-Yuek Hsiung, University of British Columbia
  • Weihong Song, University of British Columbia

Targeting metabolic dysfunction in ALS

Project Overview

In recent years, scientists have learned that changes in gut bacteria can influence overall health. In fact, evidence suggests that the gut microbiome can play a role in one’s susceptibility to diseases, including those of the brain. While studying probiotic bacterial strains in the laboratory, Dr…

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Principal Investigator:
  • Alex Parker,

    Centre hospitalier de l'Université de Montréal

Team Members:
  • Matthew Ruiz, Montreal Heart Institute, Université de Montréal

Targeting the Synaptic Pathway in Neurodevelopmental and Psychiatric Disorders

Project Overview

Autism spectrum disorders are neurodevelopmental disorders characterized by deficits in social interaction, poor communication, and restricted, stereotyped patterns of behavior. Autism and schizophrenia affect over 1% of the population, and each has strong genetic associations with 60-90% heritabili…

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Principal Investigator:
  • Ann Marie Craig,

    University of British Columbia

Team Members:
  • Michael Gordon, Brain Research Centre, University of British Columbia
  • Tim Murphy, University of British Columbia
  • Richard Brown, Dalhousie University

Targeting the telomere maintenance pathway for cancer diagnostics and therapeutics.

Project Overview

Cancer can exhibit relentless growth and relapse because of the enhanced protection of its chromosome ends. Dr. Uri Tabori is a world expert in telomeres – the protective caps at the ends of DNA. Dr. Tabori has discovered that telomeres are maintained by a section of DNA called THOR. THOR methylat…

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Principal Investigator:
  • Uri Tabori, The Hospital For Sick Children

Testing therapeutic approaches to improve cognitive dysfunction in a primate model of Alzheimer’s Disease

Project Overview

Alzheimer’s Disease (AD) is a severe dementia that is likely a result of years of buildup in the brain of molecules called amyloid-beta oligomers (AβOs). The pursuit of new disease-modifying therapeutics for AD that change the natural progression of AD early in its course is under intense investi…

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Principal Investigator:
  • Douglas Munoz, Queen's University
Team Members:
  • Stephen Scott, Queen's University
  • Douglas Cook, Queen's University
  • Ron Levy, Queen's University

Testing white matter pathway’s influence on neural communication: A combined structural and functional neuroimaging study

Project Overview

Alexandra Decker is interested in understanding how white matter development enables and constrains neural communication, which in turn, facilitates our ability to encode new memories. She will also examine how damage to white matter during development impairs neural communication, and thereby wea…

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Principal Investigator:
  • Alexandra Decker,

    University of Toronto

The Aging Brain: Circadian, Transcriptomic, and Epigenomic Dimensions

Project Overview

One of the most important questions of biomedical research is “why do we ail as we age?”. This may be in part due to a breakdown of the body’s circadian rhythm – the physiological process that tunes up or down various bodily functions during the 24 hr cycle. Another aspect of our biology tha…

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Principal Investigator:
  • Art Petronis, University of Toronto/CAMH
Team Members:
  • Jose Nobrega, Centre for Addiction and Mental Health
  • Albert Wong, Centre for Addiction and Mental Health
  • Martin Ralph, University of Toronto

The Applied Organoid Core (ApOC): a organoid production platform for modelling human brain development and disease

Project Overview

Current preclinical models to address neurological disorders fail to accurately portray human physiology. First, traditional tissue culture in which neuronal cells are grown in monolayer do not recapitulate the complex heterogeneity and function of the human brain. Second, animal models such as rode…

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Principal Investigator:
  • Liliana Attisano, University of Toronto
Team Members:
  • Jeff Wrana, Sinai Health System, Lunenfeld-Tanenbaum Research Institute
  • Laurence Pelletier, Sinai Health System, Lunenfeld-Tanenbaum Research Institute

The Automated Monitoring of Gait as a Predictor of Fall Risk

Project Overview

People with dementia are at a high risk for falls which are a leading cause of injury and can contribute to loss of independence and quality of life. Many falls could be prevented if there was a way to predict an individual’s likelihood of falling and offer interventions to reduce this risk. New r…

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Principal Investigator:
  • Babak Taati, Toronto Rehabilitation Institute

The Canadian Neonatal Brain Platform

Project Overview

The neonatal brain is exquisitely vulnerable to the biological consequences of prematurity, birth asphyxia and congenital heart defects. Brain injury and abnormal maturation in the neonatal period is associated with long-term changes in microstructure and connectivity underlying significant cognitiv…

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Principal Investigator:
  • Gregory Lodygensky, Sainte-Justine University Hospital Research Centre
Team Members:
  • Steven Miller, The Hospital For Sick Children
  • Tim Oberlander, BC Children's Hospital and BC Women's Hospital & Health Centre
  • Lionel Carmant, Sainte-Justine University Hospital Center
  • Thuy Mai Luu, Sainte-Justine University Hospital Centre
  • Adam Kirton, Alberta Children's Hospital Research Institute
  • Anne Synnes, BC Children's Hospital and BC Women's Hospital & Health Centre
  • Margot Taylor, The Hospital For Sick Children
  • Ruth Grunau, Child & Family Research Institute
  • Pierre Bellec , Université de Montreal 
  • Hilary Whyte, The Hospital For Sick Children
  • Julie Gosselin, Sainte-Justine University Hospital Centre

The Canadian Neurophotonics Platform

Project Overview

First of all, Neurophotonics refers to the use of light (e.g.: photons) to study the nervous system. The Canadian Neurophotonics Platform is a technology platform that drives development and maximizes exploitation of leading-edge technologies based on light for the study, diagnostics and treatment …

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Principal Investigator:
  • Yves De Koninck, Université Laval
Team Members:
  • Jaideep Bains, University of Calgary
  • Tim Murphy, University of British Columbia
  • Robert Campbell, University of Alberta
  • Andre Longtin, University of Ottawa
  • Alan Fine, Dalhousie University
  • Edward Ruthazer, McGill University
  • Paul De Koninck, Université Laval
  • Paul W. Wiseman, McGill University
  • Daniel Cote, Université Laval
  • Peter Grutter, McGill University
  • Timothy Kennedy, McGill University
  • Bruce Lennox, McGill University
  • Heidi McBride, McGill University
  • Anne McKinney, McGill University
  • Wayne Sossin, McGill University
  • Sridar Narayanan, McGill University

The Canadian Prospective Cohort Study to Understand Progression in Multiple Sclerosis (CanProCo)

Project Overview

Progression – or the steady worsening of disease and increase in disability – is a challenging reality faced by people affected by MS, and despite major advances in MS research, the mechanism of progression and the ways in which researchers and clinicians can track progression are still not full…

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Principal Investigator:
  • Jiwon Oh, St. Michael's Hospital
Team Members:
  • Scott Patten, University of Calgary
  • Larry Lynd, University of British Columbia
  • Shannon Kolind, University of British Columbia
  • Anthony Traboulsee, University of British Columbia
  • Alexandre Prat, CHUM Research Centre, University of Montréal
  • Roger Tam, University of British Columbia
  • Penelope Smyth, University of Alberta

The cell-type-specific organization and operation of the living human subiculum in health and epilepsy

Project Overview

The hippocampus is a brain region critical for learning, memory, spatial navigation and emotion. The main output of the hippocampus is termed the “subiculum”, and is responsible delivering hippocampal output to a host of other brain regions. As such, the subiculum is powerfully situated to brain…

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Principal Investigator:
  • Mark Cembrowski, University of British Columbia

The Douglas-Bell Canada Brain Bank: supporting human brain research in Canada and beyond

Project Overview

The Douglas-Bell Canada Brain Bank (DBCBB; douglasbrainbank.ca), based at the Douglas Mental Health University Institute (McGill University affiliate), has become one of the most important brain banks in the world. Founded in 1980 and currently in its 40th year of operation, the DBCBB currently hous…

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Principal Investigator:
  • Gustavo Turecki, Douglas Hospital Research Centre
Team Members:
  • Naguib Mechawar, Douglas Mental Health University Institute

The Effects of Glucocorticoids on the Developing Brain

Project Overview

For this project, Andrea Constantinof studied how prenatal stress affects brain development over multiple generations of offspring. She examined changes in gene expression in different brain regions of exposed offspring to identify how prenatal exposure to stress hormone can change brain signaling.…

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Principal Investigator:
  • Andrea Constantinof, University of Toronto

The effects of optogenetically activated orexin/hypocretin neurons on the mesolimbic reward pathway

Project Overview

Mr. Baimel’s work focuses upon the role of the neuropeptide, orexin, and its role in modulating the neural region which regulates reward sensations, the ventral tegmental area (VTA). The primary objective of his work was to examine alterations in synaptic transmission in the VTA in response to add…

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Principal Investigator:
  • Corey Baimel, University of British Columbia

The endocannabinoid system: a master regulator of brain and gut health in mood disorders

Project Overview

Depression will affect 1 out of 5 individuals in their lifetime. Antidepressant treatments are not effective for 30-50% patients, only 30% completely remit and do not suffer from another depressive episode, suggesting that current therapies do not address important biological mechanisms involved suc…

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Principal Investigator:
  • Caroline Menard, Université Laval

The Experimental Imaging Centre: a Local Brain Canada Platform for Preclinical MR Neuroimaging

Project Overview

The Experimental Imaging Centre Brain Canada Platform provides state of the art pre-clinical imaging to the neuroscience research community. The core technology is a 9.4T MRI with associated animal care and physiological monitoring aimed at rat and mouse models of human neuropathology. MRI has evolv…

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Principal Investigator:
  • Jeff Dunn, University of Calgary

The feasibility of hyperpolarized 13C-Pyruvate MRI for monitoring patients with intracranial metastasis

Project Overview

Surgery and radiation are standard treatments for cancer that has spread to the brain. Recent research has revealed that cancer cells with high levels of the chemical lactate are aggressive and resist radiation therapy. Dr Charles Cunningham will study whether an enhanced imaging method that can det…

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Principal Investigator:
  • Charles Cunningham, Sunnybrook Research Institute