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Our directory of funded grants

343 result(s) found

The Role of Translational Control in Cortical Dysgenesis in Mammalian Brain

Project Overview

Dr. Yang is studying genetic mechanisms that alter brain development at a molecular and cellular level, leading to changes implicated in autism spectrum disorder. He does this by studying messenger RNA translation. Previously, Dr. Yang had focused on the elF4E gene, a regulator of mRNA translation, …

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Principal Investigator:
  • Guang Yang, The Hospital For Sick Children

The Toronto Dementia Research Alliance (TDRA) Dementia Clinical Research Database: A Platform in Neurodegenerative Diseases

Project Overview

The Toronto Dementia Research Alliance will establish a clinical research platform that will provide a consistent and efficient approach to managing research and clinical care in patients with neurodegenerative conditions. The platform will provide epidemiological data, track disease burden, fill ga…

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Principal Investigator:
  • Morris Freedman, Rotman Research Institute
Team Members:
  • Stephen Strother, Rotman Research Institute
  • David Tang-Wai, University Health Network
  • Sandra Black, Sunnybrook Health Sciences Centre
  • Mario Masellis, Sunnybrook Health Sciences Centre
  • Corinne Fischer, St. Michael's Hospital
  • Alan Moody, Sunnybrook Health Sciences Centre
  • Paula Rochon, Women's College Hospital
  • Carmela Tartaglia, University Health Network
  • Nathan Herrmann, Sunnybrook Health Sciences Centre
  • Barry Greenberg, Krembil Research Institute
  • Donald Weaver, Toronto Western Research Institute, University of Toronto
  • Ron Keren, University Health Network
  • Barry Goldlist, University Health Network
  • Uri Wolf, Baycrest
  • Paul Verhoeff, Baycrest
  • Gary Naglie, Baycrest
  • A. Randy MacIntosh, Rotman Research Institute
  • William Reichman, Baycrest
  • Sanjeev Kumar, Centre for Addiction and Mental Health
  • Tarek Rajji, Centre for Addiction and Mental Health
  • Benoit Mulsant, CAMH, University of Toronto
  • Suvendrini Lena, Centre for Addiction and Mental Health
  • Sean Symons, Sunnybrook Health Sciences Centre
  • Krista Lanctot, Sunnybrook Health Sciences Centre
  • Walter Montanera, St. Michael's Hospital
  • Angie Troyer, Baycrest
  • Tom Schweizer, St. Michael's Hospital
  • Kathryn Stokes, Baycrest
  • Mary-Pat McAndrews, University Health Network
  • Prathiba Shammi, Sunnybrook Health Sciences Centre
  • Linda Mah, Rotman Research Institute, Baycrest Centre
  • Wendy Lou, University of Toronto
  • Kevin Thorpe, University of Toronto
  • Pascal Tyrrell, University of Toronto
  • Bruce Pollock, Centre for Addiction and Mental Health
  • Alex Kiss, Sunnybrook Health Sciences Centre
  • Malcolm Binns, Baycrest Health Sciences
  • Tamara Arenovich, Centre for Addiction and Mental Health
  • Susan Bronskill, ICES
  • Cheryl Grady, Baycrest
  • General Leung, St. Michael's Hospital
  • Sapna Rawal, University Health Network
  • David Mikulis, University Health Network

Three-dimensional Video-based Analysis of Infant’s Movements for Early Detection of Motor Impairment

Project Overview

This project is focused on the development of novel technologies to support clinicians in the assessment and diagnosis of cerebral palsy and motor impairment by studying infants’ movements in the first months of life. Silvia Orlandi will compare atypical and typical spontaneous movements using co…

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Principal Investigator:
  • Silvia Orlandi, Holland Bloorview Kids Rehabilitation Hospital

Toward exercise as medicine for adolescents with bipolar disorder

Project Overview

This project focuses on improving aerobic fitness (AF) among adolescents with bipolar disorder (BD). BD affects 2-5% of adolescents and is the 4th most disabling medical condition among adolescents worldwide. Even with treatment, adolescents with BD spend over half of the time with mood symptoms tha…

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Principal Investigator:
  • Benjamin Goldstein, Sunnybrook Research Institute
Team Members:
  • Brian McCrindle, The Hospital for Sick Children
  • Guy Faulkner, University of British Columbia
  • Rachel Mitchell, Sunnybrook Research Institute
  • Bradley MacIntosh, Sunnybrook Research Institute
  • Andrew Kcomt, Mood Disorders Association of Ontario and Toronto
  • Erin Michalak, University of British Columbia

Toxicity Pathways and Catalytic Potential of Cu-Containing AB Oligomers

Project Overview

The protein fragment beta-amyloid has long been a key suspect in Alzheimer’s disease. Beta-amyloid molecules have a normal function, but in Alzheimer’s they form clumps called oligomers and plaques that may be toxic to nerve cells. Recent studies indicate that beta-amyloid is more likely to form…

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Principal Investigator:
  • Tim Storr, Simon Fraser University

Tracking Alzheimer’s disease progression at the earliest stages: a multimodal project

Project Overview

New neuroimaging techniques enable us to measure the key hallmarks of Alzheimer’s disease (AD) pathology before symptoms appear. The AD pathologic process is known to begin decades before the appearance of dementia symptoms such as memory or language deficits. Therefore, Dr. Villeneuve will use th…

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Principal Investigator:
  • Sylvia Villeneuve,

    Douglas Hospital Research Centre
    (McGill University)

Team Members:
  • John Breitner, McGill University

Transforming research on chronic pain

Project Overview

Pain affects millions of people worldwide and has a profound negative effect on quality of life. Untreated pain is the most common cause of disability that impairs life. Acute pain is a normal sensation triggered by the nervous system to alert the body to an injury. Chronic pain, on the other hand, …

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Principal Investigator:
  • Michael Salter, The Hospital for Sick Children
Team Members:
  • Yves De Koninck, Université Laval
  • Jeffrey Mogil, McGill University
  • Karen D. Davis, University of Toronto
  • Min Zhuo, University of Toronto

Translating research into practice: Investigating the impact of Alzheimer’s disease diagnostics in Canada

Project Overview

Alzheimer’s disease causes progressive neurological decline and substantially decreases the quality of life of the individuals with the disease and their caregivers. Today, there are over half a million Canadians living with Alzheimer’s disease or a related form of dementia, directly costing Can…

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Principal Investigator:
  • Mari DeMarco, University of British Columbia
Team Members:
  • Howard Chertkow, McGill University
  • Mohsen Sadatsafavi, University of British Columbia
  • Ging-Yuek Hsiung, University of British Columbia
  • Howard Feldman, University of British Columbia
  • Pauline Tardif, Alzheimer Society of Canada
  • Serge Gauthier, McGill University

Treatment strategies for Autism Spectrum Disorders and Fragile-X Syndrome using mouse models, via translational control modulators

Project Overview

Aberrant control of protein synthesis (also termed translation) leads to pathological conditions like cancer, obesity, memory impairment and has been hypothesized to cause the development of Autism Spectrum Disorders (ASD) and Fragile-X syndrome (FXS). Synaptic connections are regulated by translati…

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Principal Investigator:
  • Nahum Sonenberg, McGill University
Team Members:
  • Jeffrey Mogil, McGill University
  • Antoine Adamantidis, Adamantidis
  • Jean-Claude Lacaille, Université de Montréal
  • Joseph Buxbaum, The Mount Sinai Hospital
  • Paul Hagerman, University of California, Davis
  • Randi Hagerman, University of California, Davis

Uncovering early neurocognitive risk factors for mathematical learning disorders

Project Overview

Learning disorder diagnoses are dependent on behavioural assessments that cannot be administered until the school years. As such, children do not get access to extra attention and services they need until they have already fallen behind their peers. Gaining a better understanding of the aetiology an…

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Principal Investigator:
  • Rebecca Merkley, University of Western Ontario

Understanding how deviations in postnatal hippocampal neurogenesis and circuit activity contribute to bipolar disorder with patient-derived pluripotent stem cells

Project Overview

The brain is vulnerable to many disorders that can strike at every stage of life. Bipolar disorder (BD) is a chronic and disabling neuropsychiatric condition that affects 1 in 50 Canadian adults. Like other mental illnesses, BD poses a heavy burden on society due to the cost of care and treatment, a…

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Principal Investigator:
  • Jasmin Lalonde, University of Guelph

Understanding how pain varies and its effect on well-being in children and youth with cerebral palsy: A mixed methods study

Project Overview

This research will identify how pain changes over several weeks and will assess how these short-term pain trajectories impact self-reported physical and psychological well-being in children and youth with cerebral palsy. The proposed work aims to improve pain management and the clinical care for tho…

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Principal Investigator:
  • Heather Shearer,

    Holland Bloorview Kids Rehabilitation Hospital

Understanding stress to improve mental health

Project Overview

Recent estimates indicate that 1 in 5 Canadians are affected annually by mood, anxiety and other mental illnesses. These issues are exacerbated by stress. This is important because an acute episode of stress is the most common trigger for breakthrough presentations of many mental illnesses, and when…

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Principal Investigator:
  • Jaideep Bains, University of Calgary
Team Members:
  • Stephanie Borgland, Hotchkiss Brain Institute, University of Calgary
  • Michael Hill, Hotchkiss Brain Institute, University of Calgary
  • Quentin Pittman, University of Calgary
  • Keith Sharkey, University of Calgary

Use of bone marrow cells to deliver single chain antibodies in ALS

Project Overview

This project will use cells found in bone marrow as a potential means of delivering treatments to the diseased area in brain and spinal cord. One of the biggest hurdles in treating ALS is that even if something was developed to slow down or stop the disease, the brain and spinal cord are very diffic…

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Principal Investigator:
  • Charles Krieger, Simon Fraser University

Using synthetic antibody parts to construct antibody-based imaging devices – anti-EGFR molecular targeted imaging probes for diagnosing and monitoring glioblastoma

Project Overview

To improve outcomes in brain cancer, better tools are needed to diagnose brain cancer, surgically remove brain tumours and monitor how they respond to therapy. Glioblastomas, aggressive brain cancers, are treated by surgical removal of the tumour followed by radiation and chemotherapy. A molecule fo…

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Principal Investigator:
  • Clarence Geyer, University of Saskatchewan

Validation of cognitive rehabilitation program adapted to the needs of adults with brain cancer and adult survivors of childhood brain cancer.

Project Overview

Dr. Richard’s project is developing a cognitive rehabilitation program to address impaired cognitive abilities following cancer treatment in patients. Two protocols (one offering targeted rehabilitation, the other patient support and education) are being developed to address specific needs of adul…

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Principal Investigator:
  • Nadine Richard, University Health Network

Validation of Connexins and Pannexins as a target for Alzheimer’s Disease

Project Overview

Alzheimer’s Disease (AD) is the most common cause of dementia, accounting for over two thirds of cases. As of 2013, there are over 44 million people with dementia worldwide. This number is estimated to increase to over 75 million in 2030; 1.4 million of these will be in Canada. Today, the combined…

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Principal Investigator:
  • Christian Naus, University of British Columbia
Team Members:
  • Weihong Song, University of British Columbia
  • Juan Saez, Pontificia Universidad Católica de Chile
  • Christian Giaume, Collège de France
  • Luc Leybaert, Ghent University

Validation of ocular measures as potential biomarkers for early detection of brain amyloid and neurodegeneration

Project Overview

500,000 Canadians have dementia, a number that will double within a generation due to the ongoing aging demographics of the population, with annual costs estimated to increase from $15B currently to over $150B by the year 2050. The estimated total cost to the society including the loss of productivi…

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Principal Investigator:
  • Sandra Black, Sunnybrook Health Sciences Centre
Team Members:
  • Anthony Lang, Krembil Research Institute
  • Chris Hudson , University of Waterloo
  • Lee Goldstein, Boston University
  • Barry Greenberg, Krembil Research Institute
  • Efrem Mandelcorn, Krembil Research Institute
  • Edward Margolin, Krembil Research Institute
  • Stephen Strother, Rotman Research Institute
  • Aristotle Voineskos, Centre for Addiction and Mental Health

Validation of small molecules preventing TDP-43 aggregation as a therapeutic for Amyotrophic Lateral Sclerosis

Project Overview

TDP-43 is a protein that behaves abnormally in the motor neurons of 97 per cent of people with ALS. It is usually found in the nucleus, but in people with ALS, it becomes trapped outside in the cytoplasm where it forms aggregates. One theory is that these aggregates are toxic to motor neurons. There…

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Principal Investigator:
  • Marc Shenouda, University of Toronto