Directory of funded grants

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552 results found

Understand mTOR hyperactivation during cellular interactions using a single-cell approach

  • Program Type

    Capacity building grants

  • Area of research

    Neurodevelopment

  • Disease Area

    Other

  • Competition

    Future Leaders in Canadian Brain Research

  • Province

    Québec

  • Start Date

    2023

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

The human brain is vulnerable to too much of mTOR signaling, An important neuronal pathway regulating neuronal development and activity. We study TSC, a neurodevelopmental disorder in which patients inherit a germline heterozygous mutation in genes regulating the mTOR pathway and commonly, a second somatic mutation causing mTOR hyperactivation in…

Project Ongoing

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Decoding the Spatial Architecture of Newborn Brain Injury

  • Program Type

    Capacity building grants

  • Area of research

    Neurodevelopment

  • Disease Area

    Brain Injury

  • Competition

    Future Leaders in Canadian Brain Research

  • Province

    Ontario

  • Start Date

    2023

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

Infants born early (preterm) are at risk for brain injury and long term neurodevelopmental challenges, including delays in walking, language development, and school-aged cognitive performance. Preterm brain injury is complex, but a major contributor to abnormal brain development is chronic exposure to low oxygen (hypoxia) due to lung immaturity. We…

Project Ongoing

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From Substitution to Participation: Recognizing Persons with Dementia as Social Citizens

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer Society Research Program (ASRP)

  • Province

    Québec

  • Start Date

    2023

  • Total Grant Amount

    $100,000

Project Overview

The Canadian Charter of Rights for People with Dementia states that persons with dementia must receive the support needed to participate as fully as possible in decisions that affect them. Yet people living with dementia are often excluded from participating in decisions. This study will co-develop materials that provide direction…

Project Ongoing

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Disrupting VCP/p97-GluA1 as a novel therapeutic intervention to restore synaptic plasticity in Alzheimer’s disease: A cryo-electron microscopy (cryo-EM) based approach

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer Society Research Program (ASRP)

  • Province

    British Columbia

  • Start Date

    2023

  • Total Grant Amount

    $100,000

Project Overview

Many proteins in our brain are responsible for memory and learning. These proteins frequently come together to form larger complexes. This study will explore the molecular structure of these complexes to find areas where drugs can attach and rescue diseased cells. Once these areas are located, various drugs will be…

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Amyloid deposition and the glymphatic system assessed simultaneously in Alzheimer’s disease using PET/MRI

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer Society Research Program (ASRP)

  • Province

    Ontario

  • Start Date

    2023

  • Total Grant Amount

    $100,000

Project Overview

Poor sleep is a known risk factor for Alzheimer’s disease. This is likely due to sleep’s role in removing waste products from the brain. There is currently no way to view this waste removal process without posing a risk to the individual, but new approaches using medical imagining technologies may…

Project Ongoing

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