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Our directory of funded grants

381 result(s) found

The effects of optogenetically activated orexin/hypocretin neurons on the mesolimbic reward pathway

Project Overview

Mr. Baimel’s work focuses upon the role of the neuropeptide, orexin, and its role in modulating the neural region which regulates reward sensations, the ventral tegmental area (VTA). The primary objective of his work was to examine alterations in synaptic transmission in the VTA in response to add…

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Principal Investigator:
  • Corey Baimel, University of British Columbia

The endocannabinoid system: a master regulator of brain and gut health in mood disorders

Project Overview

Depression will affect 1 out of 5 individuals in their lifetime. Antidepressant treatments are not effective for 30-50% patients, only 30% completely remit and do not suffer from another depressive episode, suggesting that current therapies do not address important biological mechanisms involved suc…

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Principal Investigator:
  • Caroline Menard, Université Laval

The Experimental Imaging Centre: a Local Brain Canada Platform for Preclinical MR Neuroimaging

Project Overview

The Experimental Imaging Centre Brain Canada Platform provides state of the art pre-clinical imaging to the neuroscience research community. The core technology is a 9.4T MRI with associated animal care and physiological monitoring aimed at rat and mouse models of human neuropathology. MRI has evolv…

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Principal Investigator:
  • Jeff Dunn, University of Calgary

The feasibility of hyperpolarized 13C-Pyruvate MRI for monitoring patients with intracranial metastasis

Project Overview

Surgery and radiation are standard treatments for cancer that has spread to the brain. Recent research has revealed that cancer cells with high levels of the chemical lactate are aggressive and resist radiation therapy. Dr Charles Cunningham will study whether an enhanced imaging method that can det…

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Principal Investigator:
  • Charles Cunningham, Sunnybrook Research Institute

The Frontier Trial – Field Randomization of NA-1 Treatment In Early Responders

Project Overview

Stroke is a life threatening emergency caused by blocked arteries that affects 45,000 Canadians a year. Each hour a stroke is left untreated means brain cells are dying. The only emergency treatment we have is a clot busting agent that can re-open blocked arteries if given within 3-4.5 hours of the …

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Principal Investigator:
  • Jim Christenson, University of British Columbia
Team Members:
  • Oscar Benavente, University of British Columbia
  • William Dick, B.C. Emergency Health Services

The impact of motherhood and APOE genotype on the aging brain

Project Overview

Women are more likely than men to be diagnosed with Alzheimer’s disease, and they also tend to develop greater declines in memory and other cognitive functions. The reasons for these discrepancies, however, have not been identified. Recent studies have found that pregnancy and motherhood promote s…

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Principal Investigator:
  • Paula Duarte-Guterman, University of British Columbia

The influence of functional connectivity on cognitive reserve

Project Overview

Declining cognitive activity is associated with a wide-variety of neurodegenerative disorders, brain injuries as well as with normal aging despite any clear pathological condition. With normal aging, there is a diverse spectrum of cognitive decline with some individuals showing strong impairments w…

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Principal Investigator:
  • Jonathan Epp, University of Calgary

The interplay of DNA regulatory elements and epigenetics in Alzheimer’s disease

Project Overview

Alzheimer’s disease (AD) is a severely disabling illness with biological causes that are not well understood. Abnormalities in gene function impacts brain activities and could cause AD. Enhancers are elements in the DNA code that enable the complex expression of genes. Epigenetic marks control enh…

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Principal Investigator:
  • Viviane Labrie, Centre for Addiction and Mental Health

The Lived Experience of Autism in an Indigenous Community: A Qualitative Study

Project Overview

Autism spectrum disorder (ASD) is characterized by difficulties with communication, social deficits as well as repetitive behaviors and interests. There is very little research on ASD in First Nations communities in Canada. We do not know how common ASD is or what challenges autistic individuals and…

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Principal Investigator:
  • Grant Bruno, University of Alberta

The McConnell Brain Imaging Center: A world-renowned multidisciplinary platform dedicated to brain research using multimodal neuroimaging and neuroinformatics

Project Overview

Thanks to the late Dr. William Feindel’s vision, who in the 1970’s believed that brain imaging was the “future for neurology and neurosurgery”, and to a generous donation, the Montreal Neurological Institute (The Neuro) inaugurated the McConnell Brain Imaging Center (BIC) in 1984. This pione…

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Principal Investigator:
  • Julien Doyon, McGill University
Team Members:
  • Douglas Arnold, McGill University
  • Sylvain Baillet, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University
  • Andrea Bernasconi, McGill University
  • Boris Bernhardt,

    McGill University

  • Danilo Bzdok, McGill University
  • Xiaoqian Chai, McGill University
  • Louis Collins, McGill University
  • Alain Dagher, McGill University
  • Simon Ducharme, McGill University
  • Alan Evans, Montreal Neurological Institute and Hospital, McGill University
  • Alexey Kostikov, McGill University
  • Marco Leyton, McGill University
  • Neda Ladbon-Bernasconi, McGill University
  • Gassan Massarweh, McGill University
  • Yasser Iturria Medina, McGill University
  • Bratislav Misic, McGill University
  • Sridar Narayanan, McGill University
  • Jamie Near, McGill University
  • Jean-Baptiste Poline, McGill University
  • Pedro Rosa-Neto, Douglas Mental Health University Institute
  • David Rudko, McGill University
  • Amir Shmuel, McGill University
  • Jean-Paul Soucy, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University
  • Nathan Spreng, McGill University
  • Christine Tardiff, McGill University
  • Sylvia Villeneuve,

    Douglas Hospital Research Centre
    (McGill University)

  • Robert Zatorre, McGill University

The McConnell Brain Imaging Centre: a Hub of Scientific Excellence for Translational Neuroimaging

Project Overview

The McConnell Brain Imaging Centre (BIC) is a major platform and research centre entirely dedicated to brain imaging. It features 7 multimodal imaging core units (MRI, PET, MEG, EEG for humans and disease models), comprehensive high-performance computing and data storage resources, and prominen…

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Principal Investigator:
  • Julien Doyon, McGill University
Team Members:
  • Robert Zatorre, McGill University
  • Louis Collins, McGill University
  • Douglas Arnold, McGill University
  • Alain Dagher, McGill University
  • Rick Hoge , McGill University
  • Pedro Rosa-Neto, Douglas Mental Health University Institute
  • Robert Hess, McGill University
  • David Ostry, McGill University
  • Howard Chertkow, McGill University
  • Andrea Bernasconi, McGill University
  • Neda Ladbon-Bernasconi, McGill University
  • Alan Evans, Montreal Neurological Institute and Hospital, McGill University
  • Alexey Kostikov, McGill University
  • Gassan Massarweh, McGill University
  • Sridar Narayanan, McGill University
  • Andrew Reader, McGill University
  • Amir Shmuel, McGill University
  • Jean-Paul Soucy, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University
  • Michael Petrides, McGill University

The Ontario Brain Epigenomics Platform

Project Overview

One of the frontiers in neuroscience is to understand the molecular dynamics of the brain functions. In addition to genetic and environmental modulation, the brain is also controlled by epigenetic mechanisms. These are chemical modifications of our genetic template that regulate gene activity in res…

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Principal Investigator:
  • Art Petronis, University of Toronto/CAMH
Team Members:
  • Cathy Barr, Toronto Western Hospital
  • Andrew Lim, Sunnybrook Health Sciences Centre
  • Freda Miller, University of Toronto
  • Lennard Niles, McMaster University
  • Nathalie Berube, University of Western Ontario
  • Michael Poulter, Robarts Research Institute
  • Ian Weaver, Dalhousie University
  • Stephen Matthews, University of Toronto
  • Vincenzo De Luca, Centre for Addiction and Mental Health

The Profile and Trajectory of Brain Tumours across the Continuum of Care in Ontario, Canada: A Population Based Study

Project Overview

The goal of Ms. Chan’s research project is to provide data on the healthcare use of patients with malignant and benign brain tumours. Specifically, the objectives of her project include:  (1) to identify the number of persons with a brain tumour in Ontario, (2) the demographic, clinical, and soci…

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Principal Investigator:
  • Vincy Chan, University of Toronto

The role of attention control and emotional regulation in the emergence of autism spectrum disorder (ASD): Identifying early behavioral markers of ASD in at-risk infants

Project Overview

Ms. Raza’s research focuses on early development in autism spectrum disorder (ASD), with the goal of identifying behavioral and physiological markers in at-risk infants. She is interested in the role early attention and emotional regulation play in the emergence of autism, and anticipate that my r…

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Principal Investigator:
  • Sarah Raza, University of Alberta

The role of cortical inhibitory cells in human epilepsy

Project Overview

Epilepsy is a debilitating neurological disorder that affects up to one percent of the world’s population. A third of epileptic patients suffer from drug-resistant form of the disease for which brain surgical intervention is often necessary. The current scientific challenge is twofold: first to ad…

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Principal Investigator:
  • Adrien Peyrache, McGill University

The role of immune genes in schizophrenia

Project Overview

The primary aim of this project was to explore the role of immune genes in schizophrenia. Ms. Pouget initially studied an association between the neuroinflammatory translocator protein (TSPO) and schizophrenia and antipsychotic induced weight gain. In order to continue investigating immune genes and…

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Principal Investigator:
  • Jennie Pouget, Centre for Addiction and Mental Health

The role of peripheral inflammation in ALS: an exploratory study

Project Overview

It has been more than a decade since scientists proved that ALS is not simply a disease of motor neurons, but that other cells in the neighbourhood around them could play an active role in the disease process. A series of intricate experiments demonstrated that genetically ‘turning off’ ALS in m…

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Principal Investigator:
  • Fabio Rossi, University of British Columbia

The Role of Translational Control in Cortical Dysgenesis in Mammalian Brain

Project Overview

Dr. Yang is studying genetic mechanisms that alter brain development at a molecular and cellular level, leading to changes implicated in autism spectrum disorder. He does this by studying messenger RNA translation. Previously, Dr. Yang had focused on the elF4E gene, a regulator of mRNA translation, …

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Principal Investigator:
  • Guang Yang, The Hospital For Sick Children

The Toronto Dementia Research Alliance (TDRA) Dementia Clinical Research Database: A Platform in Neurodegenerative Diseases

Project Overview

The Toronto Dementia Research Alliance will establish a clinical research platform that will provide a consistent and efficient approach to managing research and clinical care in patients with neurodegenerative conditions. The platform will provide epidemiological data, track disease burden, fill ga…

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Principal Investigator:
  • Morris Freedman, Rotman Research Institute
Team Members:
  • Stephen Strother, Rotman Research Institute
  • David Tang-Wai, University Health Network
  • Sandra Black, Sunnybrook Health Sciences Centre
  • Mario Masellis, Sunnybrook Health Sciences Centre
  • Corinne Fischer, St. Michael's Hospital
  • Alan Moody, Sunnybrook Health Sciences Centre
  • Paula Rochon, Women's College Hospital
  • Carmela Tartaglia, University Health Network
  • Nathan Herrmann, Sunnybrook Health Sciences Centre
  • Barry Greenberg, Krembil Research Institute
  • Donald Weaver, Toronto Western Research Institute, University of Toronto
  • Ron Keren, University Health Network
  • Barry Goldlist, University Health Network
  • Uri Wolf, Baycrest
  • Paul Verhoeff, Baycrest
  • Gary Naglie, Baycrest
  • A. Randy MacIntosh, Rotman Research Institute
  • William Reichman, Baycrest
  • Sanjeev Kumar, Centre for Addiction and Mental Health
  • Tarek Rajji, Centre for Addiction and Mental Health
  • Benoit Mulsant, CAMH, University of Toronto
  • Suvendrini Lena, Centre for Addiction and Mental Health
  • Sean Symons, Sunnybrook Health Sciences Centre
  • Krista Lanctot, Sunnybrook Health Sciences Centre
  • Walter Montanera, St. Michael's Hospital
  • Angie Troyer, Baycrest
  • Tom Schweizer, St. Michael's Hospital
  • Kathryn Stokes, Baycrest
  • Mary-Pat McAndrews, University Health Network
  • Prathiba Shammi, Sunnybrook Health Sciences Centre
  • Linda Mah, Rotman Research Institute, Baycrest Centre
  • Wendy Lou, University of Toronto
  • Kevin Thorpe, University of Toronto
  • Pascal Tyrrell, University of Toronto
  • Bruce Pollock, Centre for Addiction and Mental Health
  • Alex Kiss, Sunnybrook Health Sciences Centre
  • Malcolm Binns, Baycrest Health Sciences
  • Tamara Arenovich, Centre for Addiction and Mental Health
  • Susan Bronskill, ICES
  • Cheryl Grady, Baycrest
  • General Leung, St. Michael's Hospital
  • Sapna Rawal, University Health Network
  • David Mikulis, University Health Network

Three-dimensional Video-based Analysis of Infant’s Movements for Early Detection of Motor Impairment

Project Overview

This project is focused on the development of novel technologies to support clinicians in the assessment and diagnosis of cerebral palsy and motor impairment by studying infants’ movements in the first months of life. Silvia Orlandi will compare atypical and typical spontaneous movements using co…

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Principal Investigator:
  • Silvia Orlandi, Holland Bloorview Kids Rehabilitation Hospital