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552 results found

Quantitative fluorescence spectroscopy of the central nervous system amylome

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer Society Research Program (ASRP)

  • Province

    Alberta

  • Start Date

    2023

  • Total Grant Amount

    $100,000

Project Overview

It is generally acknowledged that accumulation of misfolded proteins (amyloid) in brains of Alzheimer’s disease patients is a key disease phenomenon. But not all amyloids cause disease, and those that do come in many different varieties. Currently, there is a lack of good ways to assess the misfolded character of…

Project Ongoing

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Control of mRNA translation in Microglia response to Alzheimer’s disease pathology

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer Society Research Program (ASRP)

  • Province

    Québec

  • Start Date

    2023

  • Total Grant Amount

    $100,000

Project Overview

Microglia are the brain’s immune cells, and their role is to protect the brain. Yet in Alzheimer’s disease, these cells are often found diseased as well. In a brain with Alzheimer’s disease, the microglia’s ability to provide instruction is defective. This study’s hypothesis is that restoring translation on microglia will…

Project Ongoing

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Alternative Strategies to Prevent Oral Pathogens Infection and Battle Alzheimer’s Disease

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer Society Research Program (ASRP)

  • Province

    Québec

  • Start Date

    2023

  • Total Grant Amount

    $200,000

Project Overview

Bacteria involved in gum disease can be found in the brains of people with Alzheimer’s disease and dementia. These bacteria help release toxins into different tissues, including the brain. And these toxins, in turn, increase amyloid beta in the brain, contributing to Alzheimer’s disease. This study will explore how gum-disease…

Project Ongoing

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Sensors for rapid detection of Alzheimer’s disease biomarker proteins

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer Society Research Program (ASRP)

  • Province

    British Columbia

  • Start Date

    2023

  • Total Grant Amount

    $100,000

Project Overview

Biomarkers are measurable indicators that help determine if a person may have, or be at risk of, developing a disease. Changes in the brain can start more than a decade before first clinical symptoms of Alzheimer’s disease. A simple test to screen for protein biomarkers may help clinicians diagnose Alzheimer’s…

Project Ongoing

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An intergenerational behavioural intervention to enhance physical activity in older adults at risk for Alzheimer’s disease

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer Society Research Program (ASRP)

  • Province

    Québec

  • Start Date

    2023

  • Total Grant Amount

    $200,000

Project Overview

Physical activity is one of the most important means of reducing risk of dementia. And new strategies are needed to support older adults in becoming more active. This study will test whether a new cross-generational intervention increases physical activity in adults over 60. The participants are at a high risk…

Project Ongoing

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