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Our directory of funded grants

406 result(s) found

The dark microglial subset displays ultrastructural and metabolic alterations in an aged mouse model of beta-amyloid pathology

Project Overview

Dr. Hubert van Tol Travel Fellowship AIMS: Recent technical advances helped to reveal the considerable heterogeneity of microglia, the resident immune cells of the central nervous system. One of these microglial subsets, the dark microglia (DM), was characterized by ultrastructural signs of cellular…

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Principal Investigator:
  • Marie-Kim St-Pierre, Université Laval

The development of an online peer navigation intervention for youth with neurodevelopmental disabilities

Project Overview

Background: Transition from the pediatric to adult health care system is a multi-faceted process that should include medical and psychosocial considerations. Despite the importance of ensuring successful transition and independence in the community, and the significant detrimental health outcomes re…

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Principal Investigator:
  • Sarah Munce, University Health Network

The Douglas-Bell Canada Brain Bank: supporting human brain research in Canada and beyond

Project Overview

The Douglas-Bell Canada Brain Bank (DBCBB; douglasbrainbank.ca), based at the Douglas Mental Health University Institute (McGill University affiliate), has become one of the most important brain banks in the world. Founded in 1980 and currently in its 40th year of operation, the DBCBB currently hous…

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Principal Investigator:
  • Gustavo Turecki, Douglas Hospital Research Centre
Team Members:
  • Naguib Mechawar, Douglas Mental Health University Institute

The Effects of Glucocorticoids on the Developing Brain

Project Overview

For this project, Andrea Constantinof studied how prenatal stress affects brain development over multiple generations of offspring. She examined changes in gene expression in different brain regions of exposed offspring to identify how prenatal exposure to stress hormone can change brain signaling.…

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Principal Investigator:
  • Andrea Constantinof, University of Toronto

The effects of optogenetically activated orexin/hypocretin neurons on the mesolimbic reward pathway

Project Overview

Mr. Baimel’s work focuses upon the role of the neuropeptide, orexin, and its role in modulating the neural region which regulates reward sensations, the ventral tegmental area (VTA). The primary objective of his work was to examine alterations in synaptic transmission in the VTA in response to add…

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Principal Investigator:
  • Corey Baimel, University of British Columbia

The endocannabinoid system: a master regulator of brain and gut health in mood disorders

Project Overview

Depression will affect 1 out of 5 individuals in their lifetime. Antidepressant treatments are not effective for 30-50% patients, only 30% completely remit and do not suffer from another depressive episode, suggesting that current therapies do not address important biological mechanisms involved suc…

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Principal Investigator:
  • Caroline Menard, Université Laval

The Experimental Imaging Centre: a Local Brain Canada Platform for Preclinical MR Neuroimaging

Project Overview

The Experimental Imaging Centre Brain Canada Platform provides state of the art pre-clinical imaging to the neuroscience research community. The core technology is a 9.4T MRI with associated animal care and physiological monitoring aimed at rat and mouse models of human neuropathology. MRI has evolv…

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Principal Investigator:
  • Jeff Dunn, University of Calgary

The feasibility of hyperpolarized 13C-Pyruvate MRI for monitoring patients with intracranial metastasis

Project Overview

Surgery and radiation are standard treatments for cancer that has spread to the brain. Recent research has revealed that cancer cells with high levels of the chemical lactate are aggressive and resist radiation therapy. Dr Charles Cunningham will study whether an enhanced imaging method that can det…

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Principal Investigator:
  • Charles Cunningham, Sunnybrook Research Institute

The Frontier Trial – Field Randomization of NA-1 Treatment In Early Responders

Project Overview

Stroke is a life threatening emergency caused by blocked arteries that affects 45,000 Canadians a year. Each hour a stroke is left untreated means brain cells are dying. The only emergency treatment we have is a clot busting agent that can re-open blocked arteries if given within 3-4.5 hours of the …

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Principal Investigator:
  • Jim Christenson, University of British Columbia
Team Members:
  • Oscar Benavente, University of British Columbia
  • William Dick, B.C. Emergency Health Services

The impact of motherhood and APOE genotype on the aging brain

Project Overview

Women are more likely than men to be diagnosed with Alzheimer’s disease, and they also tend to develop greater declines in memory and other cognitive functions. The reasons for these discrepancies, however, have not been identified. Recent studies have found that pregnancy and motherhood promote s…

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Principal Investigator:
  • Paula Duarte-Guterman, University of British Columbia

The influence of functional connectivity on cognitive reserve

Project Overview

Declining cognitive activity is associated with a wide-variety of neurodegenerative disorders, brain injuries as well as with normal aging despite any clear pathological condition. With normal aging, there is a diverse spectrum of cognitive decline with some individuals showing strong impairments w…

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Principal Investigator:
  • Jonathan Epp, University of Calgary

The interplay of DNA regulatory elements and epigenetics in Alzheimer’s disease

Project Overview

Alzheimer’s disease (AD) is a severely disabling illness with biological causes that are not well understood. Abnormalities in gene function impacts brain activities and could cause AD. Enhancers are elements in the DNA code that enable the complex expression of genes. Epigenetic marks control enh…

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Principal Investigator:
  • Viviane Labrie, Centre for Addiction and Mental Health

The McConnell Brain Imaging Center: A world-renowned multidisciplinary platform dedicated to brain research using multimodal neuroimaging and neuroinformatics

Project Overview

Thanks to the late Dr. William Feindel’s vision, who in the 1970’s believed that brain imaging was the “future for neurology and neurosurgery”, and to a generous donation, the Montreal Neurological Institute (The Neuro) inaugurated the McConnell Brain Imaging Center (BIC) in 1984. This pione…

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Principal Investigator:
  • Julien Doyon, McGill University
Team Members:
  • Douglas Arnold, McGill University
  • Sylvain Baillet, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University
  • Andrea Bernasconi, McGill University
  • Boris Bernhardt,

    McGill University

  • Danilo Bzdok, McGill University
  • Xiaoqian Chai, McGill University
  • Louis Collins, McGill University
  • Alain Dagher, McGill University
  • Simon Ducharme, McGill University
  • Alan Evans, Montreal Neurological Institute and Hospital, McGill University
  • Alexey Kostikov, McGill University
  • Marco Leyton, McGill University
  • Neda Ladbon-Bernasconi, McGill University
  • Gassan Massarweh, McGill University
  • Yasser Iturria Medina, McGill University
  • Bratislav Misic, McGill University
  • Sridar Narayanan, McGill University
  • Jamie Near, McGill University
  • Jean-Baptiste Poline, McGill University
  • Pedro Rosa-Neto, Douglas Mental Health University Institute
  • David Rudko, McGill University
  • Amir Shmuel, McGill University
  • Jean-Paul Soucy, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University
  • Nathan Spreng, McGill University
  • Christine Tardiff, McGill University
  • Sylvia Villeneuve,

    Douglas Hospital Research Centre
    (McGill University)

  • Robert Zatorre, McGill University

The McConnell Brain Imaging Centre: a Hub of Scientific Excellence for Translational Neuroimaging

Project Overview

The McConnell Brain Imaging Centre (BIC) is a major platform and research centre entirely dedicated to brain imaging. It features 7 multimodal imaging core units (MRI, PET, MEG, EEG for humans and disease models), comprehensive high-performance computing and data storage resources, and prominen…

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Principal Investigator:
  • Julien Doyon, McGill University
Team Members:
  • Robert Zatorre, McGill University
  • Louis Collins, McGill University
  • Douglas Arnold, McGill University
  • Alain Dagher, McGill University
  • Rick Hoge , McGill University
  • Pedro Rosa-Neto, Douglas Mental Health University Institute
  • Robert Hess, McGill University
  • David Ostry, McGill University
  • Howard Chertkow, McGill University
  • Andrea Bernasconi, McGill University
  • Neda Ladbon-Bernasconi, McGill University
  • Alan Evans, Montreal Neurological Institute and Hospital, McGill University
  • Alexey Kostikov, McGill University
  • Gassan Massarweh, McGill University
  • Sridar Narayanan, McGill University
  • Andrew Reader, McGill University
  • Amir Shmuel, McGill University
  • Jean-Paul Soucy, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University
  • Michael Petrides, McGill University

The Ontario Brain Epigenomics Platform

Project Overview

One of the frontiers in neuroscience is to understand the molecular dynamics of the brain functions. In addition to genetic and environmental modulation, the brain is also controlled by epigenetic mechanisms. These are chemical modifications of our genetic template that regulate gene activity in res…

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Principal Investigator:
  • Art Petronis, University of Toronto/CAMH
Team Members:
  • Cathy Barr, Toronto Western Hospital
  • Andrew Lim, Sunnybrook Health Sciences Centre
  • Freda Miller, University of Toronto
  • Lennard Niles, McMaster University
  • Nathalie Berube, University of Western Ontario
  • Michael Poulter, Robarts Research Institute
  • Ian Weaver, Dalhousie University
  • Stephen Matthews, University of Toronto
  • Vincenzo De Luca, Centre for Addiction and Mental Health

The Profile and Trajectory of Brain Tumours across the Continuum of Care in Ontario, Canada: A Population Based Study

Project Overview

The goal of Ms. Chan’s research project is to provide data on the healthcare use of patients with malignant and benign brain tumours. Specifically, the objectives of her project include:  (1) to identify the number of persons with a brain tumour in Ontario, (2) the demographic, clinical, and soci…

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Principal Investigator:
  • Vincy Chan, University of Toronto

The role of attention control and emotional regulation in the emergence of autism spectrum disorder (ASD): Identifying early behavioral markers of ASD in at-risk infants

Project Overview

Ms. Raza’s research focuses on early development in autism spectrum disorder (ASD), with the goal of identifying behavioral and physiological markers in at-risk infants. She is interested in the role early attention and emotional regulation play in the emergence of autism, and anticipate that my r…

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Principal Investigator:
  • Sarah Raza, University of Alberta

The role of cortical inhibitory cells in human epilepsy

Project Overview

Epilepsy is a debilitating neurological disorder that affects up to one percent of the world’s population. A third of epileptic patients suffer from drug-resistant form of the disease for which brain surgical intervention is often necessary. The current scientific challenge is twofold: first to ad…

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Principal Investigator:
  • Adrien Peyrache, McGill University

The role of immune genes in schizophrenia

Project Overview

The primary aim of this project was to explore the role of immune genes in schizophrenia. Ms. Pouget initially studied an association between the neuroinflammatory translocator protein (TSPO) and schizophrenia and antipsychotic induced weight gain. In order to continue investigating immune genes and…

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Principal Investigator:
  • Jennie Pouget, Centre for Addiction and Mental Health

The role of peripheral inflammation in ALS: an exploratory study

Project Overview

It has been more than a decade since scientists proved that ALS is not simply a disease of motor neurons, but that other cells in the neighbourhood around them could play an active role in the disease process. A series of intricate experiments demonstrated that genetically ‘turning off’ ALS in m…

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Principal Investigator:
  • Fabio Rossi, University of British Columbia