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Our directory of funded grants

225 result(s) found

A patient-derived iPSC platform of disease relevant cell models for biological studies

Project Overview

One of the greatest advancements in science over the past 10 years is the development of induced pluripotent stem cells (iPSCs). These cells make it possible to create essentially any cell type in the body using any other as a starting point. In ALS, iPSCs provide the opportunity to take skin or blo…

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Principal Investigator:
  • Guy Rouleau, Montreal Neurological Hospital and Institute
Team Members:
  • Stifani Stefano, McGill University
  • Benoit Coulombe, Université de Montréal
  • Jack Puymirat, Université Laval
  • Edward Fon, McGill University
  • Patrick Dion, McGill University

A Randomized Controlled Trial of Pimozide in Subjects with ALS

Project Overview

This project is a Phase II study involving 100 participants across 8 ALS clinics across Canada. The trial, led by the Principal Investigator of the Canadian Neuromuscular Disease Registry (CNDR) and the Chair of the Canadian ALS Research Network (CALS) will examine whether pimozide, a drug already a…

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Principal Investigator:
  • Lawrence Korngut, University of Calgary

A research platform to study animal and human cellular models of neurological disorders

Project Overview

Neurological diseases including neurodegenerative, neurodevelopmental, and psychiatric disorders are collectively one of the leading causes of disability to the Canadian population. This poses a significant emotional and economic burden to patients, and a major strain to the Canadian healthcare syst…

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Principal Investigator:
  • Karun Singh, McMaster University
Team Members:
  • Mick Bhatia, McMaster University
  • Kristin Hope, McMaster University
  • Sheila Singh, McMaster University
  • Eva Szabo, McMaster University

Adolescent Mental Health

Project Overview

Most mental disorders begin in adolescence; however, there are many gaps in our understanding of youth mental health. Clinical and policy gaps arise from our current inability to predict, from amongst all youth who experience mild behavioural disturbances, who will go on to develop an illness, what …

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Principal Investigator:
  • Jean Addington, Hotchkiss Brain Institute, University of Calgary
Team Members:
  • Glenda MacQueen, Hotchkiss Brain Institute, University of Calgary
  • Signe Bray, University of Calgary
  • Jonathan Downar, Toronto Western Research Institute, University of Toronto
  • Sidney H. Kennedy, University Health Network
  • Benjamin Goldstein, Sunnybrook Research Institute
  • JianLi Wang, University of Calgary
  • Catherine Lebel, University of Calgary

Advancing biology based therapies for rhabdoid brain tumours

Project Overview

Rhabdoid brain tumours are the most common brain cancers in infants. Usually these aggressive tumours are treated with intense chemotherapy and radiation therapy, which can have serious side effects. Dr Annie Huang found that these brain tumours come in 2 forms, including one that can be cured using…

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Principal Investigator:
  • Annie Huang, The Hospital For Sick Children

An Evaluation of the Acceptability of the Family Check-Up Intervention for Caregivers of Young Children with Autism Spectrum Disorders

Project Overview

This project looks at the acceptability of the Family Check-up (FCU) program for caregivers of children with Autism Spectrum Disorder (ASD). The Family Check-up is a brief, evidence-based, assessment-driven intervention that uses a strength-based and motivational interviewing approach to engage care…

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Principal Investigator:
  • Vivian Lee, McMaster University

Antipsychotic treatment in a genetic subtype of schizophrenia: Novel insights from neuroimaging and pharmacogenetics

Project Overview

Schizophrenia is a common and serious mental illness characterized by psychotic symptoms, social withdrawal and functional disabilities that are generally lifelong. Response to treatment with antipsychotics is variable and the manifestation of common side effects, including serious motor symptoms, i…

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Principal Investigator:
  • Nancy Butcher, University of Toronto

Biomarkers for Crossing the Translational Divide in Acute Spinal Cord Injury

Project Overview

Each year, over 1,500 Canadians sustain an acute spinal cord injury (SCI), and join close to 40,000 across our nation living with one of the most physically and psychologically devastating of injuries. Unfortunately, none of the promising treatments that have emerged from animal models of SCI have d…

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Principal Investigator:
  • Brian Kwon, University of British Columbia
Team Members:
  • Robert Balshaw, University of British Columbia
  • Leonard Foster, University of British Columbia
  • Christoph Borchers, University of Victoria
  • Kendall Jensen, Translational Genomics Research Institute
  • Liang Li, University of Alberta
  • Guohui Lin, University of Alberta
  • Corey Nislow, University of British Columbia
  • Vanessa Noonan, Rick Hansen Institute
  • Bruce McManus, University of British Columbia

BIOTIC: The BIOmedical Translational Imaging Centre

Project Overview

Moving neuroscience research from the lab and turning it into a product is extremely challenging. Even the most groundbreaking technologies may never improve a patient’s life if the commercialization path is not successfully navigated. For small Canadian start-up companies with a great neurotechno…

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Principal Investigator:
  • Steven Beyea, IWK Health Centre
Team Members:
  • Tim Bardouille, IWK Health Centre
  • Chris Bowen, IWK Health Centre
  • Kim Brewer, QEII Health Sciences Centre, Dalhousie University
  • Steve Patterson, IWK Health Centre
  • Lauren Petley, IWK Health Centre
  • James Rioux, QEII Health Sciences Centre, Dalhousie University

Brain channelopathies: target validation and novel therapeutic strategies

Project Overview

The entry of calcium ions into cells is mediated by a class of protein (called calcium  channels) that responds to electrical signals by opening of a calcium-selective pore.  Calcium channels are involved in a large number of physiological processes including  muscle contraction, hormone secretio…

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Principal Investigator:
  • Terry Snutch, University of British Columbia
Team Members:
  • Brian MacVicar, University of British Columbia
  • Yu Tian Wang, University of British Columbia
  • Pieter Cullis, University of British Columbia
  • John Howland, University of Saskatchewan

Brain Tumour Registry of Canada

Project Overview

The proposed initiative will make every brain tumour count! We will enhance the Canadian Cancer Registry (CCR) and brain tumour research capacity by providing data on an additional 40% of primary brain tumours diagnosed between 2010 and 2014 to the neurooncology community for the first time. The rat…

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Principal Investigator:
  • Faith Davis, University of Alberta
Team Members:
  • Jacob Easaw, University of Calgary
  • Marshall Pitz, University of Manitoba
  • Joseph Megyesi, University of Western Ontario
  • Yutaka Yasui, University of Alberta
  • Yan Yuan, University of Alberta
  • Mary McBride, BC Cancer Agency
  • Wilson Roa, University of Alberta
  • Thierry Muanza, McGill University
  • Claire Infante-Rivard, McGill University
  • Marie-Christine Guiot, Montreal Neurological Hospital and Institute

Brain-Computer Interface Integrated Augmentative and Alternative Communication

Project Overview

This projects looks at a new method to interface with communication devices through brain activity. A brain interface provides access for individuals with brain injury, or who are not typically developing, who experience limited voluntary muscle control.  Kaela Shea will investigate the possibilit…

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Principal Investigator:
  • Kaela Shea, Holland Bloorview

Brain, Mind and Consciousness

Project Overview

The Azrieli Program in Brain, Mind & Consciousness brings together 22 researchers to examine what consciousness is and how it comes about. The program is part of the Canadian Institute for Advanced Research, which was founded in 1982 to bring together researchers from across disciplines and borders …

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Principal Investigator:
  • Adrian Owen, University of Western Ontario
  • Melvyn Goodale, University of Western Ontario
Team Members:
  • Tim Bayne, University of Western Ontario
  • Axel Cleeremans, Université libre de Bruxelles
  • Dehaene Stanislas, Inserm
  • Sheena Josselyn, The Hospital For Sick Children
  • Lisa Saksida, University of Cambridge
  • Laurel Trainor, McMaster University
  • Robert Zatorre, McGill University

Bringing laser focus to voltage imaging: Enhanced indicators and advanced scanning methods for two-photon recording of dense networks in vivo

Project Overview

Recording the electrical impulses of neurons with optical methods in the brain will be enormously beneficial for understanding how the healthy brain functions, as well as how diseases of the brain impact its normal function. In this project, the team will develop methods to record electrical activit…

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Principal Investigator:
  • Katalin Toth, Université Laval

Building the Rick Hansen Alberta Spinal Cord Injury Registry

Project Overview

There are an estimated 86,000 people living with a spinal cord injury (SCI) in Canada, with an annual economic burden of $2.67 billion for those surviving the initial injury. Approximately half of SCIs are the result of a traumatic (T) incident (ex. motor vehicle accident, sports injury) and the oth…

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Principal Investigator:
  • Chester Ho, University of Calgary
Team Members:
  • Monica Gorassini, University of Alberta
  • Vivian Mushahwar, University of Alberta
  • Vanessa Noonan, Rick Hansen Institute
  • Andrew Nataraj, University of Alberta
  • Brad Jacobs, University of Calgary
  • Dalton Wolfe, Lawson Health Research Institute
  • Luc Noreau, Université Laval
  • Patrick Whelan, University of Calgary

Canadian Open Neuroscience Platform

Project Overview

The Canadian Open Neuroscience Platform (CONP) is a national platform for open sharing of neuroscience research data and brings together many of the country’s leading scientists in basic and clinical neuroscience to form an interactive network of collaborations in brain research, interdisciplinary…

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Principal Investigator:
  • Alan Evans, Montreal Neurological Institute and Hospital, McGill University
Team Members:
  • Stephen Strother, Rotman Research Institute
  • Stephen Scherer, The Hospital For Sick Children
  • Yoshua Bengio, Université de Montréal
  • Jon Stoessl, University of British Columbia
  • James Kennedy, Centre for Addiction and Mental Health
  • Simon Duchesne, Université Laval
  • Glenda MacQueen, Hotchkiss Brain Institute, University of Calgary
  • Guy Rouleau, Montreal Neurological Hospital and Institute
  • Ingrid Johnsrude, University of Western Ontario
  • Tristan Glatard, Concordia University

Canadian Paediatric Stroke Imaging Research Platform: Harnessing an International Focus

Project Overview

Stroke is a leading cause of adult and childhood focal brain injury and disability. Most stroke patients die or face disability (mental or physical), impacting individuals for many decades. Children are 3 times more likely to have normal motor outcomes than adults with similar strokes. However, the …

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Principal Investigator:
  • Nomazulu Dlamini, The Hospital For Sick Children
Team Members:
  • Trish Domi, University of Toronto
  • Andrea Kassner, The Hospital For Sick Children
  • Adam Kirton, Alberta Children's Hospital Research Institute
  • Bruce Bjornson, University of British Columbia
  • Michael Rivkin, Boston Children's Hospital
  • Mubeen Rafay, Winnipeg Children's Hospital
  • Stephen Strother, Rotman Research Institute
  • Steven Miller, The Hospital For Sick Children
  • Gabrielle A. deVeber, Hospital for Sick Children

Canadian Partnership for Stroke Recovery Clinical Trials Platform

Project Overview

The overall goals of the Canadian Partnership for Stroke Recovery Clinical Trials Platform is to create a national network of stroke rehabilitation clinical trial sites, help train future researchers and test potential high impact new recovery approaches. Dr. Bayley and his team will do this…

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Principal Investigator:
  • Mark Bayley, Toronto Rehabilitation Institute
Team Members:
  • Dale Corbett, University of Ottawa
  • Sandra Black, Sunnybrook Health Sciences Centre
  • William McIlroy, University of Waterloo
  • Michelle Ploughman, Memorial University of Newfoundland
  • Sean Dukelow, University of Calgary
  • Janice Eng, University of British Columbia
  • Stephen Strother, Rotman Research Institute
  • Marilyn MacKay-Lyons, Dalhousie University
  • Robert Teasell, Parkwood Institute

Canadian rTMS Treatment and Biomarker Network in Depression (CARTBIND) Trial

Project Overview

Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for patients with depression who have not responded to antidepressant medications. rTMS involves stimulating the brain with a series of magnetic pulses delivered through a hand-held magnetic coil. Treatment duration is abo…

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Principal Investigator:
  • Zafiris Daskalakis, Centre for Addiction and Mental Health
Team Members:
  • Fidel Vila-Rodriguez, University of British Columbia
  • Aristotle Voineskos, Centre for Addiction and Mental Health
  • Sidney H. Kennedy, University Health Network
  • Raymond Lam, University of British Columbia
  • Jonathan Downar, Toronto Western Research Institute, University of Toronto
  • Daniel Blumberger, Centre for Addiction and Mental Health
  • Tarek Rajji, Centre for Addiction and Mental Health
  • Gustavo Turecki, Douglas Hospital Research Centre
  • Christopher Honey, University of Toronto