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545 results found

Correlating quaternary structure of pathological protein aggregates with phenotypic presentation of ALS

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2024

  • Total Grant Amount

    $125,000

Project Overview

Amyotrophic lateral sclerosis (ALS) is a disease of progressive weakness that leads to death within a few years of onset. The disease can start in one arm, leg, or face, but it inevitably spreads to all areas, killing cells as it spreads. What if, once the disease starts, we could…

Investigating mechanisms of altered lipid droplet dynamics in ALS

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2024

  • Total Grant Amount

    $125,000

Project Overview

In Canada, the annual cost to care for individuals with neurodegenerative diseases is over $10.4 billion. There are no therapeutic interventions that sufficiently prevent or treat neurodegenerative diseases because the cause of neurodegeneration is complex and not well understood. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease caused by…

Investigating inhibition of TDP-43 propagation as a therapeutic strategy for ALS

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2024

  • Total Grant Amount

    $125,000

Project Overview

It is not known why ALS is a rapidly progressing disease. The discovery that the accumulation of TAR DNA-binding protein 43 kDa (TDP-43) is a pathological hallmark of sporadic ALS and a subset of frontotemporal lobar degeneration (FTLD) provides clues. TDP-43 is prone to incorrect folding and it has been…

Dynamic palmitoylation regulates TDP-43 nucleocytoplasmic transport in ALS

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2024

  • Total Grant Amount

    $125,000

Project Overview

Common features in amyotrophic lateral sclerosis (ALS) include misdirected proteins that build up over time and lead to large protein clumps that are toxic to the cell and lead to cell death. In ALS, special cells known as motor neurons are particularly affected. These neurons have very long extensions known…

Role of neurofilament NFL depletion in TDP-43-mediated pathogenesis

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2024

  • Total Grant Amount

    $125,000

Project Overview

his proposal is based on our finding of substantial depletion of neurofilament synthesis in mouse models of ALS with abnormal accumulations of TDP-43, a hallmark of the disease. This is due to a selective block of NF-L synthesis on ribosome machinery that is explained by the binding of excess cytoplasmic…