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Our directory of funded grants

335 result(s) found

A mixed-methods evaluation of a dance therapy intervention for students seeking on-campus mental health services

Project Overview

Decades of dance research have demonstrated the positive benefits of dance in terms of improving quality of life and reducing symptomatology for diverse groups of participants. Dance may improve mood, body image, self-esteem, and support healing processes for persons suffering from physical, cogniti…

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Principal Investigator:
  • Isabel Fortier, McGill University
Team Members:
  • Sarah Berry, McGill University
  • Joseph FX DeSouza, York University
  • Debora Rabinovich, York University
  • Rebecca Barnstaple, York University

A multi-platform approach to the functional assessment of ASD gene variants

Project Overview

The high and potentially increasing prevalence of Autism Spectrum Disorder (ASD) is taking a significant emotional and economic toll on patients, their families and Canadian society. Although progress has been made in identifying genes associated with ASD, the underlying mechanism of this disorder r…

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Principal Investigator:
  • Kathryn Post, Brain Research Centre, University of British Columbia

A National biobank and database for patients with traumatic brain injury

Project Overview

Traumatic brain injury is the leading cause of death and disability in children and young adults in Canada. Despite huge developments in basic neuroscience, no new therapies or diagnostic tests have been introduced in clinical care over the past 30 years. In the acute setting, neither clinicians nor…

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Principal Investigator:
  • Jamie Hutchison, The Hospital For Sick Children
Team Members:
  • Andrew Baker, St. Michael's Hospital
  • Karen Barlow, Alberta Children's Hospital Research Institute
  • David Clarke, Capital District Health Authority
  • Michael Esser, Alberta Children's Hospital Research Institute
  • Robin Green, Toronto Rehabilitation Institute
  • Anne-Marie Guerguerian, The Hospital For Sick Children
  • Jacques Lacroix, Sainte-Justine University Hospital Centre
  • Alain Ptito, McGill University
  • Keith Walley, James Hogg Research Institute
  • Grant Iverson, University of British Columbia
  • Anthony G. Phillips, University of British Columbia
  • Elizabeth Theriault, University of British Columbia
  • Cheryl Wellington, University of British Columbia
  • Suzanne Vercauteren, BC Children’s Hospital (BCCH)
  • Ash Singhal, BC Children's Hospital and BC Women's Hospital & Health Centre
  • Peter Skippen, BC Children’s Hospital (BCCH)
  • Elaine Gilfoyle, Alberta Children's Hospital Research Institute
  • Ari Joffe, University of Alberta
  • David Zygun, University of Alberta
  • Clare Gallagher, University of Calgary
  • Thomas Sawyer, University of Calgary
  • Sam Weiss, University of Calgary
  • Brent Winston, University of Calgary
  • Greg Hansen, Manitoba Children’s Hospital
  • Murray Kesselman, Manitoba Children’s Hospital
  • Peter Dirks, The Hospital For Sick Children
  • Cynthia Hawkins, The Hospital For Sick Children
  • Angela Colantonio, University of Toronto
  • Karen Choong, McMaster University
  • Alison Fox-Robichaud, McMaster University
  • Patricia Liaw, McMaster University
  • Jane Batt, St. Michaels Hospital
  • Shiva Amiri, Ontario Brain Institute (OBI)
  • Donald Stuss, Ontario Brain Institute (OBI)
  • Douglas Fraser, Children’s Health Research Institute
  • Corinne Kagan, Ontario Neurotrauma Foundation (ONF)
  • Michelle Keightley, Holland Bloorview Kids Rehabilitation Hospital
  • Martin Osmond, Children’s Hospital of Eastern Ontario (CHEO)
  • Roger Zemek, Children’s Hospital of Eastern Ontario (CHEO)
  • Charles H Tator, Krembil Research Institute
  • Catherine Farrell, Sainte-Justine University Hospital Centre
  • Ronald Gottesman, Montreal Children’s Hospital (MCH)
  • Paul Hébert, Centre hospitalier de l'Université de Montréal (CHUM)
  • Bonnie Swaine, Centre hospitalier de l'Université de Montréal (CHUM)
  • Alexis Turgeon, Université Laval
  • Lynne Fenerty, Dalhousie University

A national coordinating neuroinformatics framework for autism and related conditions

Project Overview

New approaches in neurodevelopmental research increasingly seek to integrate enormous amounts of data through sophisticated informatics so as to determine the relationship between genotype and phenotypes, both structural and functional, as they change over time during development. Such approaches dw…

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Principal Investigator:
  • Alan Evans, Montreal Neurological Institute and Hospital, McGill University
Team Members:
  • Mayada Elsabbagh, McGill University
  • Sébastien Jacquemont, Sainte-Justine University Hospital Research Centre
  • Guy Rouleau, Montreal Neurological Hospital and Institute
  • Stephen Scherer, The Hospital For Sick Children
  • Peter Szatmari, Centre for Addiction and Mental Health
  • Evdokia Anagnostou,

    Holland Bloorview Kids Rehabilitation Hospital

  • Teresa Bennett, McMaster University
  • Bruce Pike, Montreal Neurological Hospital and Institute
  • Laurent Mottron, Université de Montréal

A Novel Microfluidic Platform for Investigating Axonal Sprouting in Motor Neurons

Project Overview

Motor neurons are extremely complex cells. Not only do they have an intricate set of inner workings, but they have a long wire-like portion called an axon that connects the central nervous system to muscles called an axon. Understanding all of the aspects of how axons are guided through the body is …

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Principal Investigator:
  • Amir Sanati Nezhad, University of Calgary

A Novel Zebrafish-Based Platform for Anticonvulsant Drug Development

Project Overview

Epilepsy is a common neurological condition that affects 1-2% of the population. Despite dozens of anticonvulsant medications, over a third of patients remain refractory to drugs and our goal is to uncover novel therapies for this patient population. Here, we propose to create a national platform fo…

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Principal Investigator:
  • Deborah Kurrasch, University of Calgary
Team Members:
  • Jong Rho, University of Calgary
  • Jeffrey Buchhalter, University of Calgary
  • Mary Connolly, University of British Columbia

A Patient-Derived hiPSC Neuronal Platform for Drug Discovery in Parkinson’s Disease and Amyotrophic Lateral Sclerosis

Project Overview

Parkinson’s Disease (PD) and Amyotrophic Lateral Sclerosis (ALS) are two of the most common and devastating neurodegenerative diseases, affecting more than 2% of the population over the age of 65. However, a major hindrance in developing therapies for disorders of the brain has been limited access…

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Principal Investigator:
  • Edward Fon, McGill University
Team Members:
  • Guy Rouleau, Montreal Neurological Hospital and Institute
  • Nicolas Dupré, CRCHUQ-Enfant-Jesus, University Laval
  • Tom Pfeifer, Centre for Drug Research and Development
  • Neil Cashman, University of British Columbia
  • Thomas Durcan, Montreal Neurological Institute and Hospital, McGill University
  • Philippe Seguela, McGill University

A patient-derived iPSC platform of disease relevant cell models for biological studies

Project Overview

One of the greatest advancements in science over the past 10 years is the development of induced pluripotent stem cells (iPSCs). These cells make it possible to create essentially any cell type in the body using any other as a starting point. In ALS, iPSCs provide the opportunity to take skin or blo…

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Principal Investigator:
  • Guy Rouleau, Montreal Neurological Hospital and Institute
Team Members:
  • Stifani Stefano, McGill University
  • Benoit Coulombe, Université de Montréal
  • Jack Puymirat, Université Laval
  • Edward Fon, McGill University
  • Patrick Dion, McGill University

A Randomized Controlled Trial of Pimozide in Subjects with ALS

Project Overview

This project is a Phase II study involving 100 participants across 8 ALS clinics across Canada. The trial, led by the Principal Investigator of the Canadian Neuromuscular Disease Registry (CNDR) and the Chair of the Canadian ALS Research Network (CALS) will examine whether pimozide, a drug already a…

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Principal Investigator:
  • Lawrence Korngut, University of Calgary

A research platform to study animal and human cellular models of neurological disorders

Project Overview

Neurological diseases including neurodegenerative, neurodevelopmental, and psychiatric disorders are collectively one of the leading causes of disability to the Canadian population. This poses a significant emotional and economic burden to patients, and a major strain to the Canadian healthcare syst…

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Principal Investigator:
  • Karun Singh, McMaster University
Team Members:
  • Mick Bhatia, McMaster University
  • Kristin Hope, McMaster University
  • Sheila Singh, McMaster University
  • Eva Szabo, McMaster University

Adolescent Mental Health

Project Overview

Most mental disorders begin in adolescence; however, there are many gaps in our understanding of youth mental health. Clinical and policy gaps arise from our current inability to predict, from amongst all youth who experience mild behavioural disturbances, who will go on to develop an illness, what …

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Principal Investigator:
  • Jean Addington, Hotchkiss Brain Institute, University of Calgary
Team Members:
  • Glenda MacQueen, Hotchkiss Brain Institute, University of Calgary
  • Signe Bray, University of Calgary
  • Jonathan Downar, Toronto Western Research Institute, University of Toronto
  • Sidney H. Kennedy, University Health Network
  • Benjamin Goldstein, Sunnybrook Research Institute
  • JianLi Wang, University of Calgary
  • Catherine Lebel, University of Calgary

Advanced multi-functional in vivo retinal imaging for ocular oncology

Project Overview

Need for project: Choroidal tumors present clinicians with many challenges. The overlap between clinical and imaging findings combined with the difficulty of performing choroidal biopsies can create diagnostic dilemmas. Obtaining a diagnosis is paramount in optimizing patient outcomes, minimizing sy…

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Principal Investigator:
  • Zaid Mammo, University of British Columbia
Team Members:
  • Myeong Jin Ju, University of British Columbia
  • Katherine Paton, BC Cancer Agency
  • Marinko Sarunic, Simon Fraser University

Advanced pharmacokinetics and pharmacodynamics for phase Ib/IIa trial of repurposed enoxacin therapy for patients with ALS

Project Overview

A Phase 1/2 clinical trial led by Dr. Angela Genge and co-recipient Dr. Eran Hornstein is currently underway to test the safety and tolerability of enoxacin in people living with ALS. Enoxacin is an antibiotic that on a cellular level is known to activate an enzyme called DICER, which in turn can in…

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Principal Investigator:
  • Angela Genge, McGill University
Team Members:
  • Eran Hornstein, Weizmann Institute of Science
  • Iddo Magen, Weizmann Institute of Science

Advancing biology based therapies for rhabdoid brain tumours

Project Overview

Rhabdoid brain tumours are the most common brain cancers in infants. Usually these aggressive tumours are treated with intense chemotherapy and radiation therapy, which can have serious side effects. Dr Annie Huang found that these brain tumours come in 2 forms, including one that can be cured using…

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Principal Investigator:
  • Annie Huang, The Hospital For Sick Children

An EEG platform for national and international EEG-based neuroscience (EEGNet)

Project Overview

EEG is a non-invasive, inexpensive, and efficient tool for measuring electrical signals in the brain. The EEGNet platform will provide a standardized, open repository of EEG data for the investigation of biomarkers of brain disorders that manifest themselves during the early years of life, disorders…

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Principal Investigator:
  • Alan Evans, Montreal Neurological Institute and Hospital, McGill University
Team Members:
  • Mayada Elsabbagh, McGill University
  • Yves De Koninck, Université Laval
  • Philippe Albouy, Université Laval
  • Shirley Fecteau, Université Laval
  • Isabelle Blanchette, Université Laval
  • Célyne Bastien, Université Laval
  • Christophe Grova, Concordia University
  • Anne Gallagher, Université de Montréal
  • Sarah Lippe, Sainte-Justine University Hospital Research Centre
  • Sid Segalowitz, Brock University
  • Adrian Owen, University of Western Ontario
  • Ingrid Johnsrude, University of Western Ontario
  • Stefanie Blain-Moraes, McGill University
  • Faranak Farzan, Centre for Addiction and Mental Health
  • Jorge Bosch Bayard, McGill University
  • Signe Bray, University of Calgary
  • Ashley Harris, University of Calgary
  • Sean Hill, University of Toronto
  • Jean Gotman, McGill University
  • Birgit Frauscher, McGill University
  • Stefon Van Noordt, McGill University
  • Erin Panda, Brock University
  • Ayda Tekok-Kilic, Brock University
  • Christine Lackner, Mount St. Vincent University
  • Karen Campbell, Brock University
  • Teena Willoughby, Brock University

An Evaluation of the Acceptability of the Family Check-Up Intervention for Caregivers of Young Children with Autism Spectrum Disorders

Project Overview

This project looks at the acceptability of the Family Check-up (FCU) program for caregivers of children with Autism Spectrum Disorder (ASD). The Family Check-up is a brief, evidence-based, assessment-driven intervention that uses a strength-based and motivational interviewing approach to engage care…

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Principal Investigator:
  • Vivian Lee, McMaster University

An interdisciplinary approach to mindfulness as a quality of life improvement factor for people with ALS and their primary caregivers

Project Overview

Mindfulness is a therapeutic technique that teaches one to focus on the present moment, while calmly acknowledging and accepting their feelings, thoughts, and bodily sensations. Previous research has demonstrated that learning mindfulness can help with navigating grief and benefit overall quality of…

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Principal Investigator:
  • Angela Genge, McGill University
Team Members:
  • Francesco Pagnini, Università Cattolica del Sacro Cuore
  • Lana Kim McGeary, ALS Clinic, Montreal Neurological Institute
  • Antonietta Vitale, ALS Clinic, Montreal Neurological Institute
  • Kendra Berry, ALS Clinic, Montreal Neurological Institute
  • Maura Fisher, ALS Clinic, Montreal Neurological Institute
  • Kalyna Franko, ALS Clinic, Montreal Neurological Institute
  • Rami Massie, ALS Clinic, Montreal Neurological Institute

Antipsychotic treatment in a genetic subtype of schizophrenia: Novel insights from neuroimaging and pharmacogenetics

Project Overview

Schizophrenia is a common and serious mental illness characterized by psychotic symptoms, social withdrawal and functional disabilities that are generally lifelong. Response to treatment with antipsychotics is variable and the manifestation of common side effects, including serious motor symptoms, i…

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Principal Investigator:
  • Nancy Butcher, University of Toronto

Assistive technology for cognition to increase safety at home

Project Overview

Maintaining the ability to prepare meals independently in Alzheimer’s disease (AD) is of paramount importance to the individuals themselves and to their caregivers. Beyond being necessary to feed oneself, meal preparation supports self-esteem and maintenance of social roles. However, numerous diff…

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Principal Investigator:
  • Nathalie Bier, Université de Montréal

Biological and Pathological relevance of hnRNP A1B; An alternative splice variant of TDP-43

Project Overview

In 97 per cent of ALS cases and nearly half of cases of frontotemporal dementia, the TDP-43 protein is misplaced to an area outside the cell nucleus of the motor neuron called the cytoplasm. The mislocated TDP-43 may be toxic to motor neurons because it aggregates in the cytoplasm, or because it is …

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Principal Investigator:
  • Myriam Gagné,

    Centre Hospitalier de l'Université de Montréal