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586 results found

Novel digital and adaptive marker of word-finding difficulties for early detection of Alzheimer’s disease

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer Society Research Program (ASRP)

  • Province

    Québec

  • Start Date

    2024

  • Total Grant Amount

    $200,000

  • Health Canada Contribution

    $100,000

Project Overview

Over 64% of older adults without neurocognitive disorders report forgetting the names of objects when speaking. These difficulties are commonly dismissed as typical aspects of the normal aging process. However, recent findings suggest that when these subjective word-finding challenges reach a certain level, they can serve as an indicator of…

A “tipping point” neuron type driving Alzheimer’s Disease progression

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer Society Research Program (ASRP)

  • Province

    British Columbia

  • Start Date

    2024

  • Total Grant Amount

    $200,000

  • Health Canada Contribution

    $100,000

Project Overview

Alzheimer's Disease (AD) is characterized by dysregulation of neurons involved in memory, which is believed to be caused by the production of an agent termed "amyloid beta". Amyloid beta spreads across the brain during the progression of Alzheimer's disease, with the current belief being that hyperactive neurons drive this spread…

DBS-PPN-AD: A Pilot Clinical Trial Investigating Deep Brain Stimulation of the Pedunculopontine Nucleus for theTreatment of Alzheimer’s Disease

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer Society Research Program (ASRP)

  • Province

    Ontario

  • Start Date

    2024

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

Gamma oscillations (GO) are electrical signals detected in the brain that are essential for memory and cognition. GO are a product of the activity of a subpopulation of brain cells called parvalbumin interneurons (PVIN).Unsurprisingly, GO and PVIN are both impaired in Alzheimer’s disease (AD). Remarkably, stimulation of PVIN has restored…

Health system implications of novel therapeutics for Alzheimer’s Disease: Supporting capacity planning with real-world evidence

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer Society Research Program (ASRP)

  • Province

    Ontario

  • Start Date

    2024

  • Total Grant Amount

    $99,951

  • Health Canada Contribution

    $49,975

Project Overview

Close to 600,000 Canadians currently live with Alzheimer’s disease and related dementias, but effective therapies are limited and focus on symptom management rather than a cure. Emerging research promises new disease-modifying drug therapies which target removal of amyloid in the brain and slow disease progression. While initial results from clinical…

Targeting the USP19 deubiquitinating enzyme for the treatment of Alzheimer’s disease

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer Society Research Program (ASRP)

  • Province

    Québec

  • Start Date

    2024

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

Alzheimer’s disease progresses over time due to the spreading of aggregates of tau protein and amyloid protein from unaffected to affected regions of the brain. At this time, we do not understand how these aggregates spread and how to prevent the spreading. We recently discovered that taking out the USP19…