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Our directory of funded grants

426 result(s) found

Advanced pharmacokinetics and pharmacodynamics for phase Ib/IIa trial of repurposed enoxacin therapy for patients with ALS

Project Overview

A Phase 1/2 clinical trial led by Dr. Angela Genge and co-recipient Dr. Eran Hornstein is currently underway to test the safety and tolerability of enoxacin in people living with ALS. Enoxacin is an antibiotic that on a cellular level is known to activate an enzyme called DICER, which in turn can in…

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Principal Investigator:
  • Angela Genge, McGill University
Team Members:
  • Eran Hornstein, Weizmann Institute of Science
  • Iddo Magen, Weizmann Institute of Science

Advancing biology based therapies for rhabdoid brain tumours

Project Overview

Rhabdoid brain tumours are the most common brain cancers in infants. Usually these aggressive tumours are treated with intense chemotherapy and radiation therapy, which can have serious side effects. Dr Annie Huang found that these brain tumours come in 2 forms, including one that can be cured using…

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Principal Investigator:
  • Annie Huang, The Hospital For Sick Children

Aerobic exercise for treatment of Chronic symptoms following mild Traumatic Brain Injury (ACTBI) Trial

Project Overview

Dr. Matthew Galati Brain Changer Award Annually, approximately 250,000 people in Canada sustain a concussion. While symptoms following concussion generally improve within 3 months, up to 30% of people continue to have symptoms beyond this time. Symptoms may include headaches, fatigue, trouble sleepi…

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Principal Investigator:
  • Leah Mercier, University of Calgary

AID-ME: Artificial Intelligence in Depression – Medication Enhancement: A Randomized, Patient and Rater Blinded, Active-Controlled Trial of a DeepLearning Enabled Clinical Decision Aid for Personalized Depression Treatment Selection

Project Overview

We are testing a new digital mental health solution for physicians to better manage the treatment of depression. While many treatment options for depression are available, individual responses to treatment vary tremendously. Almost 70% of patients will not recover after their first treatment attempt…

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Principal Investigator:
  • Manuela Ferrari, Douglas Hospital Research Centre
Team Members:
  • Gustavo Turecki, Douglas Hospital Research Centre

An EEG platform for national and international EEG-based neuroscience (EEGNet)

Project Overview

EEG is a non-invasive, inexpensive, and efficient tool for measuring electrical signals in the brain. The EEGNet platform will provide a standardized, open repository of EEG data for the investigation of biomarkers of brain disorders that manifest themselves during the early years of life, disorders…

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Principal Investigator:
  • Alan Evans, Montreal Neurological Institute and Hospital, McGill University
Team Members:
  • Mayada Elsabbagh, McGill University
  • Yves De Koninck, Université Laval
  • Philippe Albouy, Université Laval
  • Shirley Fecteau, Université Laval
  • Isabelle Blanchette, Université Laval
  • Célyne Bastien, Université Laval
  • Christophe Grova, Concordia University
  • Anne Gallagher, Université de Montréal
  • Sarah Lippe, Sainte-Justine University Hospital Research Centre
  • Sid Segalowitz, Brock University
  • Adrian Owen, University of Western Ontario
  • Ingrid Johnsrude, University of Western Ontario
  • Stefanie Blain-Moraes, McGill University
  • Faranak Farzan, Centre for Addiction and Mental Health
  • Jorge Bosch Bayard, McGill University
  • Signe Bray, University of Calgary
  • Ashley Harris, University of Calgary
  • Sean Hill, University of Toronto
  • Jean Gotman, McGill University
  • Birgit Frauscher, McGill University
  • Stefon Van Noordt, McGill University
  • Erin Panda, Brock University
  • Ayda Tekok-Kilic, Brock University
  • Christine Lackner, Mount St. Vincent University
  • Karen Campbell, Brock University
  • Teena Willoughby, Brock University

An Evaluation of the Acceptability of the Family Check-Up Intervention for Caregivers of Young Children with Autism Spectrum Disorders

Project Overview

This project looks at the acceptability of the Family Check-up (FCU) program for caregivers of children with Autism Spectrum Disorder (ASD). The Family Check-up is a brief, evidence-based, assessment-driven intervention that uses a strength-based and motivational interviewing approach to engage care…

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Principal Investigator:
  • Vivian Lee, McMaster University

An identity crisis of satiety neurons: how prolonged metabolic stress can reprogram the hypothalamus

Project Overview

The prevalence of obesity has reached pandemic levels and represents a massive societal and economic burden. Findings of the last decades on how the brain controls what is known as energy balance, or the “Energy In, Energy out”, have pushed scientists to consider obesity as a disease of the nerv…

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Principal Investigator:
  • Alexandre Fisette, Université du Québec à Trois-Rivières

An interdisciplinary approach to mindfulness as a quality of life improvement factor for people with ALS and their primary caregivers

Project Overview

Mindfulness is a therapeutic technique that teaches one to focus on the present moment, while calmly acknowledging and accepting their feelings, thoughts, and bodily sensations. Previous research has demonstrated that learning mindfulness can help with navigating grief and benefit overall quality of…

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Principal Investigator:
  • Angela Genge, McGill University
Team Members:
  • Francesco Pagnini, Università Cattolica del Sacro Cuore
  • Lana Kim McGeary, ALS Clinic, Montreal Neurological Institute
  • Antonietta Vitale, ALS Clinic, Montreal Neurological Institute
  • Kendra Berry, ALS Clinic, Montreal Neurological Institute
  • Maura Fisher, ALS Clinic, Montreal Neurological Institute
  • Kalyna Franko, ALS Clinic, Montreal Neurological Institute
  • Rami Massie, ALS Clinic, Montreal Neurological Institute

Antenatal prediction of preterm birth: placental function, fetal and neonatal brain development

Project Overview

Fetal growth restriction is associated with pregnancy complications, as well as high rates of preterm birth and childhood disabilities. This is a complex disorder that impacts the development of the placenta and limits blood flow to the fetal brain, depriving the fetus of oxygen and nutrients needed…

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Principal Investigator:
  • Emma Duerden, Western University

Antipsychotic treatment in a genetic subtype of schizophrenia: Novel insights from neuroimaging and pharmacogenetics

Project Overview

Schizophrenia is a common and serious mental illness characterized by psychotic symptoms, social withdrawal and functional disabilities that are generally lifelong. Response to treatment with antipsychotics is variable and the manifestation of common side effects, including serious motor symptoms, i…

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Principal Investigator:
  • Nancy Butcher, University of Toronto

Assistive technology for cognition to increase safety at home

Project Overview

Maintaining the ability to prepare meals independently in Alzheimer’s disease (AD) is of paramount importance to the individuals themselves and to their caregivers. Beyond being necessary to feed oneself, meal preparation supports self-esteem and maintenance of social roles. However, numerous diff…

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Principal Investigator:
  • Nathalie Bier, Université de Montréal

BCi-Move: Empowering severely disabled children to achieve power mobility with brain-computer interfaces (BCIs)

Project Overview

Thousands of Canadian children living with severe physical disability are intellectually capable but unable to move independently. They are trapped inside their bodies, deprived of their fundamental human rights to interact and participate. An emerging technology, brain-computer interfaces (BCIs), a…

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Principal Investigator:
  • Adam Kirton, Alberta Children's Hospital Research Institute

BEAM: Building Emotional Awareness and Mental Health in Parenting. An appbased intervention to improve postpartum mental health and support children’s brain development

Project Overview

Postpartum mental health problems, including depression and anxiety, affect 15-20% of people and are a serious public health concern. Untreated postpartum mental health problems can be long-lasting, and lead to behaviour problems, brain changes, and risk for later mental illness in children. Rates o…

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Principal Investigator:
  • Catherine Lebel, University of Calgary
Team Members:
  • Lianne Tomfohr-Madsen, University of Calgary
  • Gerald Giesbrecht, University of Calgary
  • Leslie Roos, University of Manitoba
  • Tim Oberlander, BC Children's Hospital and BC Women's Hospital & Health Centre
  • Lara Leijser, University of Calgary

Biological and Pathological relevance of hnRNP A1B; An alternative splice variant of TDP-43

Project Overview

In 97 per cent of ALS cases and nearly half of cases of frontotemporal dementia, the TDP-43 protein is misplaced to an area outside the cell nucleus of the motor neuron called the cytoplasm. The mislocated TDP-43 may be toxic to motor neurons because it aggregates in the cytoplasm, or because it is …

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Principal Investigator:
  • Myriam Gagné,

    Centre Hospitalier de l'Université de Montréal

Biomarkers for Crossing the Translational Divide in Acute Spinal Cord Injury

Project Overview

Each year, over 1,500 Canadians sustain an acute spinal cord injury (SCI), and join close to 40,000 across our nation living with one of the most physically and psychologically devastating of injuries. Unfortunately, none of the promising treatments that have emerged from animal models of SCI have d…

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Principal Investigator:
  • Brian Kwon, University of British Columbia
Team Members:
  • Robert Balshaw, University of British Columbia
  • Leonard Foster, University of British Columbia
  • Christoph Borchers, University of Victoria
  • Kendall Jensen, Translational Genomics Research Institute
  • Liang Li, University of Alberta
  • Guohui Lin, University of Alberta
  • Corey Nislow, University of British Columbia
  • Vanessa Noonan, Rick Hansen Institute
  • Bruce McManus, University of British Columbia

BIOTIC: The BIOmedical Translational Imaging Centre

Project Overview

Moving neuroscience research from the lab and turning it into a product is extremely challenging. Even the most groundbreaking technologies may never improve a patient’s life if the commercialization path is not successfully navigated. For small Canadian start-up companies with a great neurotechno…

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Principal Investigator:
  • Steven Beyea, IWK Health Centre
Team Members:
  • Tim Bardouille, IWK Health Centre
  • Chris Bowen, IWK Health Centre
  • Kim Brewer, QEII Health Sciences Centre, Dalhousie University
  • Steve Patterson, IWK Health Centre
  • Lauren Petley, IWK Health Centre
  • James Rioux, QEII Health Sciences Centre, Dalhousie University

Brain and cognitive effects of long-term gender affirming hormone therapy in aging trans women

Project Overview

Trans women may take estradiol-based gender affirming hormone therapy (GAHT) into their old age. Yet, we know little about the long-term brain health effects of GAHT. We propose to further our understanding of the earliest causes and signs of cognitive and brain aging effects in women by exploring t…

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Principal Investigator:
  • Gillian Einstein, University of Toronto

Brain channelopathies: target validation and novel therapeutic strategies

Project Overview

The entry of calcium ions into cells is mediated by a class of protein (called calcium  channels) that responds to electrical signals by opening of a calcium-selective pore.  Calcium channels are involved in a large number of physiological processes including  muscle contraction, hormone secretio…

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Principal Investigator:
  • Terry Snutch, University of British Columbia
Team Members:
  • Brian MacVicar, University of British Columbia
  • Yu Tian Wang, University of British Columbia
  • Pieter Cullis, University of British Columbia
  • John Howland, University of Saskatchewan

Brain Gain: Identifying candidate dementia-related biomarkers and early intervention strategies for adults aged 50+ with a history of mild traumatic brain injury

Project Overview

Dr. Matthew Galati Brain Changer Award One hundred and forty-four thousand Canadians suffer a diagnosed concussion each year. A concussion is a type of mild traumatic brain injury, often caused by a bump to the head or body that causes one’s brain to move within the skull. This movement causes mic…

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Principal Investigator:
  • Taylor Snowden, University of Victoria

Brain pericyte calcium signaling during vasomotion and neurovascular coupling

Project Overview

The brain requires a large amount of energy and oxygen for survival. In order to meet these requirements, the blood supply to the brain is tightly controlled to ensure that active areas receive more blood. Recently, cells known as pericytes, which are found on small blood vessels, were shown to play…

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Principal Investigator:
  • Jillian Stobart, University of Manitoba