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545 results found

Cholinergic & noradrenergic contributions to presymptomatic AD progression

  • Program Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer’s Association International Grant Program

  • Province

    Québec

  • Start Date

    2022

  • Total Grant Amount

    $188,595

  • Health Canada Contribution

    $85,725

Project Overview

The development of approaches to aid early detection of the transition from healthy aging to mild cognitive impairment and Alzheimer’s disease (AD) is critically important for developing targeted strategies to halt or slow disease progression. Post-mortem studies have identified AD-related brain changes years and even decades before the age of…

Serotonin circuit dysregulation in Alzheimer’s Disease

  • Program Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer’s Association International Grant Program

  • Province

    Alberta

  • Start Date

    2022

  • Total Grant Amount

    $190,481

  • Health Canada Contribution

    $86,582

Project Overview

The early and severe loss of serotonin neurons along with the neuroprotective effects of SSRIs in Alzheimer’s Disease (AD) strongly implicates the serotonin system in disease pathology. Yet, mechanisms underlying the vulnerability and contribution of the serotonin system to AD progression remain unknown. Serotonergic impairment early in disease process is…

Electrophysiological measures of proteinopathy in asymptomatic older adults

  • Program Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer’s Association International Grant Program

  • Province

    Québec

  • Start Date

    2022

  • Total Grant Amount

    $190,378

  • Health Canada Contribution

    $86,537

Project Overview

Our project proposes the development and first-step validation of a new, noninvasive mapping procedure of proteinopathy in asymptomatic older adults. Our approach consists in applying recent advances in magnetoencephalography (MEG) methods that yield the neurophysiological fingerprint of each individual from short recordings of task-free brain activity. We will test the…

Detecting Behaviours of Risk in Nursing Homes using Deep Learning

  • Program Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer’s Association International Grant Program

  • Province

    Ontario

  • Start Date

    2022

  • Total Grant Amount

    $190,489

  • Health Canada Contribution

    $86,585

Project Overview

Many people with dementia (PwD) live in nursing homes, which often suffer from a lack of skilled staff to support and monitor the safety of residents. Behavioural and psychological symptoms of dementia are commonly seen as a result of this lack of support and can be associated with risk for…

From Space to Memory Under Pathological Tau

  • Program Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Alzheimer’s

  • Competition

    Alzheimer’s Association International Grant Program

  • Province

    Québec

  • Start Date

    2022

  • Total Grant Amount

    $196,985

  • Health Canada Contribution

    $85,725

Project Overview

Among the earliest signs of preclinical Alzheimer’s disease (AD) are navigation impairments and the presence of abnormal Tau (aTau) proteins in the entorhinal cortex (EC), a brain region that represents space and movement. As AD progresses aTau spreads to the subiculum (Sub), a key region for memory encoding and retrieval.…