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552 results found

Dynamic palmitoylation regulates TDP-43 nucleocytoplasmic transport in ALS

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2024

  • Total Grant Amount

    $125,000

Project Overview

Common features in amyotrophic lateral sclerosis (ALS) include misdirected proteins that build up over time and lead to large protein clumps that are toxic to the cell and lead to cell death. In ALS, special cells known as motor neurons are particularly affected. These neurons have very long extensions known…

Project Ongoing

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Role of neurofilament NFL depletion in TDP-43-mediated pathogenesis

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2024

  • Total Grant Amount

    $125,000

Project Overview

his proposal is based on our finding of substantial depletion of neurofilament synthesis in mouse models of ALS with abnormal accumulations of TDP-43, a hallmark of the disease. This is due to a selective block of NF-L synthesis on ribosome machinery that is explained by the binding of excess cytoplasmic…

Project Ongoing

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Developing machine learning models of disease progression and survival outcomes in ALS patients: evaluating the utility of structural brain MRI as an ALS biomarker

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2024

  • Total Grant Amount

    $125,000

Project Overview

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with no known cure, leading to progressive loss of motor function and ultimately the death of the patient. While it is known that patients with ALS experience changes in certain brain regions, the relationships between these brain-related changes, patient symptoms, and survival…

Project Ongoing

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Therapeutic validation of gene-based strategies aimed at restoring neuronal KCC2 in ALS

  • Program Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada-Brain Canada Career Transition Award

  • Province

    Québec

  • Start Date

    2024

  • Total Grant Amount

    $250,000

Project Overview

An imbalance between excitation and inhibition is one of the earliest detectable features of amyotrophic lateral sclerosis (ALS). In fact, changes in the inhibitory synaptic system appears to be central to this imbalance and the modulation of this system using potassium-chloride co-transporter 2 (KCC2)-enhancing compounds have proven to be an…

Project Ongoing

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Investigating disease progression and survival outcomes in ALS patients using deep learning and deformation based morphometry

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    2023 ALS Canada - Brain Canada Trainee Program

  • Province

    Québec

  • Start Date

    2023

  • Total Grant Amount

    $78,000

Project Overview

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder with no known cure, leading to progressive loss of motor function and ultimately the death of the patient. While it is known that patients with ALS experience brain changes, particularly in motor areas, the relationships between brain-related changes, patient symptom profiles, and…

Project Ongoing

See the project and researchers