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Role of microglia-derived factors in glial scar formation and axonal regeneration failure after spinal cord injury

  • Program Type

    Capacity building grants

  • Area of research

    Injury

  • Disease Area

    Other

  • Competition

    Turnbull-Tator Award in Spinal Cord Injury and Concussion Research

  • Province

    Québec

  • Start Date

    2021

  • Total Grant Amount

    $50,000

  • Health Canada Contribution

    $25,000

Project Overview

The role of microglia in spinal cord injury (SCI) has remained obscure for decades. Microglia, the resident immune cells of the brain and spinal cord, were historically perceived as harmful to neurons and their supporting cells (collectively termed as glial cells) in the context of injury. However, the possibility remains that microglia may have been confused in previous research with macrophages that infiltrate the site of SCI from the bloodstream and adopt many of the same markers…

Restoration of mitochondrial function by activation of the NAD+/Sirtuin pathway to treat PD

  • Program Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Parkinson's

  • Competition

    Other

  • Province

    Québec

  • Start Date

    2020

  • Total Grant Amount

    $50,000

  • Health Canada Contribution

    $25,000

Project Overview

Parkinson’s Disease (PD) is a debilitating neurodegenerative disease for which there is no cure. The cardinal motor symptoms of PD are caused by the massive loss of neurons in a region of the brain called the substantia nigra pars compacta (SNc), that use dopamine as a chemical messenger (Giguère et…

Comprehensive Analysis Platform To Understand, Remedy and Eliminate ALS

  • Program Type

    Platform grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    2019 Platform Support Grants

  • Province

    Alberta

  • Start Date

    2021

  • Total Grant Amount

    $2,850,000

  • Health Canada Contribution

    $1,425,000

Project Overview

Amyotrophic lateral sclerosis (ALS) is a terminal disease that paralyzes people because the brain is no longer able to communicate with the muscles that we are typically able to move at will. One of the challenges is that ALS is a very heterogeneous disease, meaning that each person’s disease is…

Canadian Optogenetics and Vectorology Foundry

  • Program Type

    Platform grants

  • Area of research

    Neurotechnology

  • Disease Area

    Other

  • Competition

    2019 Platform Support Grants

  • Province

    Québec

  • Start Date

    2020

  • Total Grant Amount

    $4,275,000

  • Health Canada Contribution

    $2,137,500

Project Overview

Optogenetics is a relatively new science subdomain that is revolutionizing brain research with great promises for therapeutics. Oxford dictionary defines it as a technique in neuroscience in which genes for light-sensitive proteins are introduced into specific types of brain cells in order to monitor and control their activity precisely using…

SLAP-CAN In vivo Imaging Facility

  • Program Type

    Platform grants

  • Area of research

    Neurotechnology

  • Disease Area

    Other

  • Competition

    2019 Platform Support Grants

  • Province

    Ontario

  • Start Date

    2021

  • Total Grant Amount

    $3,326,912

  • Health Canada Contribution

    $1,663,455

Project Overview

The central nervous system (CNS, the brain and spinal cord together) is perhaps the most complex biological entity in the world. The CNS allows us to experience our environment, to feel pleasure and pain, and to remember events that take place in our lives. Understanding how the CNS works is…