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Our directory of funded grants

381 result(s) found

Characterizing the roles of synapse organizers in mediating synaptic function and brain-based diseases

Project Overview

The human brain is made up of neural circuits that are thought to underlie all brain function. These circuits are made up of contact points called synapses where individual nerve cells communicate with each other. For many years, scientists have been working to shed light on how nerve cells transm…

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Principal Investigator:
  • Hong Lu, University of British Columbia

Cholinergic & noradrenergic contributions to presymptomatic AD progression

Project Overview

Alzheimer’s Association International Research Grant Program: Alzheimer’s Association Research Grant (AARG) The development of approaches to aid early detection of the transition from healthy aging to mild cognitive impairment and Alzheimer’s disease (AD) is critically important for developing…

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Principal Investigator:
  • Nathan Spreng, McGill University

Circadian control of microglial activation in chronic pain states

Project Overview

Circadian, or 24-hour, rhythms control almost all biological systems in our bodies with sleep-wake cycles and body temperature control the best known examples. Interestingly, pain is also governed by these 24-hour rhythms. People suffering from chronic neuropathic pain have been found to rate their …

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Principal Investigator:
  • Nader Ghasemlou, Queen's University

Closed-loop deep brain stimulation using chronic intracranial cortical sensing to inform subcortical stimulation delivery

Project Overview

Many patients with Parkinson’s disease experience freezing of gait (FoG), a debilitating symptom defined by “episodic absences or marked reduction of forward progression of the feet despite the intention to walk.” FoG can lead to reduced mobile independence and increased risk of falls, which c…

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Principal Investigator:
  • Luka Milosevic, University Health Network

Co-clinical trials in mice and humans in autism

Project Overview

Autism has many causes, yet no single cause explains why many children and adults have autism. This makes treating the symptoms of autism difficult, since how somebody responds to treatment might depend on what cause autism in the first place. We thus need both better treatments and ways of figuring…

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Principal Investigator:
  • Evdokia Anagnostou,

    Holland Bloorview Kids Rehabilitation Hospital

  • Jason Lerch, University of Toronto
Team Members:
  • Jane Foster, McMaster University
  • Barry Greenberg, Krembil Research Institute
  • Robert Nicolson, University of Western Ontario
  • Teresa Bennett, McMaster University
  • Rosanna Weksberg, The Hospital For Sick Children
  • Stephen Scherer, The Hospital For Sick Children

Co-clinical trials of autism in mice and humans

Project Overview

Autism is a neuro-developmental disorder characterized by social/communication deficits and repetitive behaviours. It is very heterogeneous, with over 250 genes implicated, but is highly heritable. The current therapeutic approach is frequently ineffective partly because often a single treatment is …

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Principal Investigator:
  • Zsuzsa Lindenmaier,

    University of Toronto

Cognitive Outcomes and Response/Remission Efficacy of Convulsive Therapies in Treatment Resistant Depression: The CORRECT-TRD Trial

Project Overview

Magnetic Seizure Therapy (MST) is a novel form of treatment that uses high intensity magnetic field pulses to stimulate the brain and induce a seizure as a therapeutic intervention for patients with depression resistant to antidepressant medication, known as Treatment Resistant Depression (TRD). Pre…

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Principal Investigator:
  • Daniel Blumberger, Centre for Addiction and Mental Health
Team Members:
  • Shawn McClintock, Duke University
  • Kiran Rabheru, University of Ottawa
  • Fidel Vila-Rodriguez, University of British Columbia
  • Zafiris Daskalakis, Centre for Addiction and Mental Health
  • Sarah Lisanby, Duke University
  • Mustafa Husain, Duke University
  • Jonathan Downar, Toronto Western Research Institute, University of Toronto

Combining neurostimulation technique with tailored interventions for the affected upper extremity: can it promote better recovery in stroke survivors?

Project Overview

A substantial proportion of individuals are left with poor residual functioning of the affected arm after a stroke. This has a tremendous impact on the quality of life and the ability for stroke survivors to live independently. While exercise is considered essential to any rehabilitation program, it…

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Principal Investigator:
  • Marie-Hélène Milot, Université de Sherbrooke
Team Members:
  • François Tremblay, University of Ottawa
  • Marie-Hélène Boudrias, McGill University
  • Hélène Corriveau, Université de Sherbrooke

Comprehensive Analysis Platform To Understand, Remedy and Eliminate ALS

Project Overview

Amyotrophic lateral sclerosis (ALS) is a terminal disease that paralyzes people because the brain is no longer able to communicate with the muscles that we are typically able to move at will. One of the challenges is that ALS is a very heterogeneous disease, meaning that each person’s disease is d…

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Principal Investigator:
  • Sanjay Kalra, University of Alberta
Team Members:
  • Nicolas Dupré, CRCHUQ-Enfant-Jesus, University Laval
  • Angela Genge, McGill University
  • Lorne Zinman, Sunnybrook Research Institute
  • Janice Robertson, University of Toronto
  • Christine Vande Velde, Université de Montréal
  • Ekaterina Rogaeva, University of Toronto
  • Tania Bubela, Simon Fraser University
  • Russell Greiner, University of Alberta
  • Wendy Johnston, University of Alberta

Correction of Neuronal Function in Autism

Project Overview

The prevalence of autism spectrum disorders (ASDs) is rising dramatically on a yearly basis and new interventional strategies are required to treat ASDs and related disorders like Fragile X syndrome. Altered communication between brain cells may lead to the defects responsible for the features that …

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Principal Investigator:
  • Laurie Doering, McMaster University
Team Members:
  • Min Zhuo, University of Toronto
  • Ali Pejmun Haghighi, McGill University
  • David Nelson, Baylor College of Medicine

Cortical GABAergic interneurons migration impairment in genetic epileptic encephalopathies

Project Overview

This project aims at elucidating the roles of new candidate genes in brain development, particularly in the context of refractory paediatric epilepsies (epileptic encephalopathies) and co-morbid neurodevelopmental disorders such as autism and intellectual deficiency.  Lara Eid is particularly inter…

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Principal Investigator:
  • Lara Eid, CHU-Saint Justine

CRF receptor-mediated sensitization of 5-HT2A receptor signalling

Project Overview

Anxiety and depression often present as co-morbid disorders and the expression and severity of these illnesses is commonly associated with stressful experiences. Both are widespread and serious disorders that affect the lives of 10-15% of Canadians for most of their lifetime. There are multiple pote…

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Principal Investigator:
  • Cornelia Walther, University of Western Ontario

Crosstalk between immune response and metabolic signaling: targeting leptin/AMPK axis to restore metabolic homeostasis in ALS

Project Overview

Increased metabolism (hypermetabolism) is a characteristic often associated with more aggressive, faster progressing cases of ALS. Recently, after studying blood plasma samples from people with more rapidly progressing disease, Dr. Jasna Kriz discovered that fast progressing individuals often have d…

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Principal Investigator:
  • Jasna Kriz, Université Laval
Team Members:
  • Nicolas Dupré, CRCHUQ-Enfant-Jesus, University Laval
  • Angela Genge, McGill University

Cyto-iGluSnFR: A glutamate biosensor platform for brain diseases

Project Overview

In the human brain and retina, the chemical glutamate is a very important messenger that carries information from one neuron to another. The levels of glutamate transmitted between neurons must be tightly controlled: too high and neurons die, too low and information is not communicated properly. In …

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Principal Investigator:
  • Don van Meyel, Research Institute of the McGill University Health Centre
Team Members:
  • Keith Murai, Research Institute of the McGill University Health Centre
  • Adriana Di Polo, CHUM Research Centre, University of Montréal
  • Tim Murphy, University of British Columbia

Cytosolic DNA sensing in ALS-related neuroinflammation

Project Overview

Recently, Dr. Honglin Luo, in collaboration with Dr. Neil Cashman, discovered that mutations in the ALS-linked SOD1 gene result in activation of a specific neuroinflammatory pathway called cGAS-STING. Neuroinflammation is thought to play an important role in the progression of ALS and activation of …

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Principal Investigator:
  • Honglin Luo, University of British Columbia
Team Members:
  • Neil Cashman, University of British Columbia

Deciphering eEF2K biological functions for therapeutic targeting of neural tumours

Project Overview

In childhood, medulloblastoma (a form of brain cancer) and neuroblastoma (a cancer that starts in the nerve cells) can be aggressive and hard to treat. Dr Poul Sorensen’s group is targeting what he believes is the Achilles heel of tumour cells: namely, how they adapt and survive under stress. He h…

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Principal Investigator:
  • Poul Sorensen, University of British Columbia

Decoding motor cortex circuit abnormalities at ALS onset through combined two-photon imaging in vivo and pharmacogenetics

Project Overview

ALS is a disease that is characterized by degeneration of both upper and lower motor neurons, and while a significant proportion of work has focused on motor neurons in the spinal cord, the motor cortex in the brain, where electrical signals to your muscles originate have clear, but poorly understoo…

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Principal Investigator:
  • Lisa Topolnik,

    CHUL, Université Laval

Decoding the RNA stability programs that determine cell identity and function in human brain and neurodegenerative disorders

Project Overview

The brain cells in Alzheimer’s disease patients differ extensively from healthy brain cells at the molecular level: there are hundreds of genes that are normally active in the brain, but become inactive in Alzheimer’s. Similarly, Alzheimer’s disease appears to turn on hundreds of genes that ar…

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Principal Investigator:
  • Hamed Najafabadi, McGill University