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552 results found

Profiling Cortical Excitability in ALS Using Threshold Tracking Transcranial Magnetic Stimulation and Multimodal Biomarkers

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    2023 ALS Canada - Brain Canada Trainee Program

  • Province

    Ontario

  • Start Date

    2023

  • Total Grant Amount

    $75,000

Project Overview

Rationale: Cortical hyperexcitability has been identified to be a potential driver of ALS pathology leading to excitotoxicity and degeneration of upper motor neurons (UMNs)in the primary motor cortex (M1) and the subsequent degeneration of lower motor neurons (LMNs) in the spinal cord. Transcranial magnetic stimulation (TMS) is a non-invasive neurophysiological…

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Determining the contribution of acute viral infection on the onset and progression of ALS

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    2023 ALS Canada - Brain Canada Trainee Program

  • Province

    Ontario

  • Start Date

    2023

  • Total Grant Amount

    $25,000

Project Overview

Almost all amyotrophic lateral sclerosis (ALS) is accompanied by neuronal cytoplasmic aggregates of TAR DNA-binding protein-43 (TDP-43). TDP-43 is an RNA-binding protein that regulates RNA expression and function, including mRNA translation. The mechanisms by which TDP-43 pathology contributes to ALS remain incompletely understood, hampering the development of a rational therapy…

Project Ongoing

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Defective protein translation: a causative pathway in ALS?

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    2023 ALS Canada - Brain Canada Trainee Program

  • Province

    British Columbia

  • Start Date

    2023

  • Total Grant Amount

    $75,000

Project Overview

Almost all amyotrophic lateral sclerosis (ALS) is accompanied by neuronal cytoplasmic aggregates of TAR DNA-binding protein-43 (TDP-43). TDP-43 is an RNA-binding protein that regulates RNA expression and function, including mRNA translation. The mechanisms by which TDP-43 pathology contributes to ALS remain incompletely understood, hampering the development of a rational therapy…

Project Ongoing

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Development of a shared decision-making aid for bulbar symptom management in ALS

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    2023 ALS Canada - Brain Canada Trainee Program

  • Province

    Ontario

  • Start Date

    2023

  • Total Grant Amount

    $50,000

Project Overview

Bulbar disease, which affects speech and swallowing functions, is considered to be one of the most debilitating aspects of ALS by patients. It is characterized by a rapid progression, short survival after diagnosis, and poorer quality of life. Clinical management of bulbar symptoms is focused on optimizing patients’ function and…

Project Ongoing

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Resetting Microglia Activation in Offspring Exposed to Maternal High-Fat Diet

  • Program Type

    Capacity building grants

  • Area of research

    Central Nervous System

  • Disease Area

    Other

  • Competition

    Master's Personnel Awards for Black Scholars

  • Province

    Ontario

  • Start Date

    2023

  • Total Grant Amount

    $50,000

Project Overview

Nutrition and diet are factors in life that contribute drastically to a person’s brain health, and overall quality of life, and high-fat diets can be considered a cause of many harmful physical and cognitive conditions. In rodent models, exposing the mother to a high-fat diet has been shown to negatively…

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