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Our directory of funded grants

254 result(s) found

Drug Delivery across the Human Blood-Brain Barrier

Project Overview

Toxic amyloid proteins are known to be a significant contributing factor in the development of Alzheimer’s disease. Abnormal clusters of protein fragments build up between nerve cells in the brainleading to impaired memory. The most important therapies in development currently are biologics, antib…

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Principal Investigator:
  • Nathan Yoganathan, KalGene Pharmaceuticals Inc
Team Members:
  • Louis Collins, McGill University
  • Jean-Paul Soucy, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University
  • Danica Stanimirovic, National Research Council of Canada
  • Balu Chakravarthy, Carleton University
  • Pedro Rosa-Neto, Douglas Mental Health University Institute

Drug repurposing in medulloblastoma using integrated functional genomic, epigenomic, and transcriptomic approaches

Project Overview

The project conducted by Dr. Gendoo is focused upon identifying potential therapeutic targets against Medulloblastoma (MB) subtypes. Identification of subtype-specific therapies is contingent upon: 1) proper classification of samples into MB subtypes; and 2) proper understanding of the pharmacologic…

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Principal Investigator:
  • Deena Gendoo, The Hospital For Sick Children

Dysregulation of integrated stress response (ISR) pathway in Fragile X syndrome and autism

Project Overview

This project is focused on role of the integrated stress response (ISR) pathway in fragile X syndrome as well as autism.  Mehdi Hooshmandi is aiming to figure out the exact ISR pathway abnormalities in different cell types and regions of the brain. Once the altered molecule(s) is identified, it wil…

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Principal Investigator:
  • Mehdi Hooshmandi, McGill University

Early Brain Development Following Prenatal Exposure to SSRI Antidepressants and Maternal Depression

Project Overview

Many women experience depression during pregnancy, and are often faced with challenging decisions surrounding antidepressant use during this critical time for their developing child. Fetal exposure to maternal antidepressant use is poorly understood, and further, the effects are often lef…

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Principal Investigator:
  • Kayleigh Campbell, BCCHR

Early Postnatal Metabolic Treatment for the Fetal Alcohol Syndrome

Project Overview

Fetal Alcohol Syndrome (FAS) is the result of in utero alcohol exposure and is characterized by central nervous system developmental impairments which causes lifelong physical and cognitive disabilities. The mechanisms of the impaired brain development are poorly understood, but they seem to be rela…

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Principal Investigator:
  • Paolo Bazzigaluppi, Toronto Western Hospital

Early Years Intervention on a First Nations Reserve

Project Overview

Recognizing that the 9 months before birth and the early years of a child’s life are the most critical period in the shaping of the structures and functions of the brain, and the importance of high quality, culturally appropriate early childhood programming for Indigenous children and families pri…

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Principal Investigator:
  • Bryan Kolb, University of Lethbridge
  • Melissa Tremblay, University of Alberta

Effects of Sex Hormone Therapy on Brain Development in Adolescents Experiencing Gender Dysphoria: A Magnetic Resonance Imaging Study

Project Overview

Adolescence is a time of rapid brain maturation that is partly influenced by sex hormones. In this project, magnetic resonance imaging will be used to assess the influence of sex hormones on brain structure and function. Malvina Skorska will examine how the brain structure and function of adolescent…

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Principal Investigator:
  • Malvina Skorska, University of Toronto

Electrically guided transcranial stimulation of cells chemogenically primed for excitability a novel, non-invasive and cell type-specific approach

Project Overview

I propose to test a new and potentially groundbreaking experimental technique called EC stimulation, which will enable researchers to influence the activity of different kinds of neurons in any part of the brain without the need of major brain invasive surgery or complex genetic techniques. This wil…

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Principal Investigator:
  • Francis Bambico, Memorial University of Newfoundland

Enhancing the efficacy of heat shock protein inducers by cotreatment with a histone deacetylase inhibitor – A therapeutic strategy for ALS

Project Overview

In ALS and many other neurodegenerative diseases, one of the defining characteristics is that proteins can become misfolded and clump together, potentially damaging nerve cells. When a healthy body responds to stress, protective mechanisms increase the production of heat shock proteins that help pre…

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Principal Investigator:
  • Heather Durham, McGill University
Team Members:
  • Chantelle Sephton, Université Laval
  • Richard Robitaille, Université de Montréal
  • Josephine Nalbantoglu, McGill University

Epigenetic mechanisms underlying dendritic atrophy in ALS

Project Overview

Motor neurons are made up of three distinct regions. The top of the neuron is composed of branches like a tree called dendrites that receive information to transmit. The middle part of the neuron is called the cell body where the majority of the life processes occur and the bottom consists of a sing…

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Principal Investigator:
  • Heather Durham, McGill University

Epigenetics and mental health: the Canadian neuroepigenetics network

Project Overview

Psychiatry, like all areas of medicine and biology, has long considered the origins of individual differences. This issue ultimately produced a nature vs nurture schism that divided researchers who emphasized the importance of environmental influences from those who considered the importance of heri…

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Principal Investigator:
  • Michael J. Meaney, Douglas Mental Health University Institute
Team Members:
  • Paul R. Albert, Ottawa Hospital Research Institute
  • Guillaume Bourque, McGill University
  • Gustavo Turecki, Douglas Hospital Research Centre
  • Michael Kobor, University of British Columbia
  • Thomas Boyce, University of British Columbia
  • Joanna Holbrook, Singapore Institute for Clinical Sciences

Evaluation of electrical activity as a tumour suppressor in medulloblastoma

Project Overview

Dr. Garzia works on a type of pediatric brain cancer called medulloblastoma. Kids affected by this tumor are either not cured or experience severe side effects due to the aggressive therapy. This proposal explores a possible causative link between altered neural activity and brain tumors. The team h…

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Principal Investigator:
  • Livia Garzia, McGill University Health Centre Research Institute (RI-MUHC)

Evaluation of the Kids Write Network (KWN) intervention with children of severely ill parents: a qualitative and quantitative pilot study

Project Overview

Adolescence represents a unique developmental window of the life cycle to adopt healthy behaviours that will support psychosocial adjustment and well-being during adolescence and adulthood (World Health Organization, 2001). This research project seeks to evaluate the Kids Write Network (KWN) interv…

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Principal Investigator:
  • Danielle Groleau, McGill University
Team Members:
  • Ingrid Sladeczek, McGill University

Examining the role of KCC2 in maintaining the balance between excitation and inhibition in ALS

Project Overview

In this project, Dr. Sahara Khademullah will establish whether a protein called KCC2 (potassium chloride cotransporter 2), which is found to be lower in people with sporadic ALS than in people without the disease, is a viable target to prevent or stop ALS progression. Dr. Khademullah will determine …

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Principal Investigator:
  • Sahara Khademullah, Université Laval

Gangliosides in Huntington’s disease: from bench to clinics and back

Project Overview

Huntington disease (HD) is an inherited disorder that causes progressive malfunctioning and death of parts of the brain that control movement, reasoning and emotions. HD patients also suffer from depression and personality changes.  There is no cure for HD. Symptoms progress steadily until patients…

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Principal Investigator:
  • Simonetta Sipione, University of Alberta
Team Members:
  • Jonathan Curtis, University of Alberta
  • Sylvain Chouinard, CHUM Research Centre, University of Montréal
  • Oksana Suchowersky, University of Alberta
  • Justyna Sarna, University of Calgary
  • Richard Fahlman, University of Alberta

Generating expanded repeats in the C9ORF72 ortholog in zebrafish

Project Overview

Over the past several years, zebrafish have proven to be a valuable model to study motor neuron degeneration and search for new treatments. To date, several key mutations that cause ALS in humans (SOD1, TDP-43, FUS, etc.) have been introduced to zebrafish resulting in motor neuron dysfunction and an…

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Principal Investigator:
  • Gary Armstrong,

    Montreal Neurological Institute, McGill University

Genomic markers of cerebral small vessel ischemia

Project Overview

Damage to the small blood vessels of the brain is a major contributor to stroke and dementia. While risk factors for vascular disease such as smoking, diabetes, high blood pressure and elevated cholesterol contribute to small vessel disease, we currently lack methods to identify patients at risk of …

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Principal Investigator:
  • Liam Brunham, University of British Columbia

Habitual physical activity, exercise and cardiovascular function in spinal cord injury

Project Overview

Approximately 11,000 individuals in North America sustain a spinal cord injury (SCI) every year. Presently there are over 300,000 people living with SCI in the North America. A SCI is one of the most serious injuries known to humankind. The total annual health cost for Canadians with SCI approaches …

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Principal Investigator:
  • Christopher West, University of British Columbia

Hippocampal heterogeneity in health and disease

Project Overview

The brain is estimated to contain 100 billion cells that form 100 trillion connections. Brain cells speak to each other by releasing chemicals into a small area known as the synapse, and neighboring cells can listen by using their ability to sense these chemicals. Like our daily conversations, brain…

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Principal Investigator:
  • Matthew Parsons, Memorial University of Newfoundland

Human inducible pluripotent stem cells (iPSC) platform

Project Overview

Studies of genetic disorders are limited because of the lack of appropriate tissue samples from patients. A promising avenue to overcome this deficit is the recently described method of converting adult cells into inducible pluripotent stem cells (iPSC)1, and differentiating them into desired cell t…

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Principal Investigator:
  • Jack Puymirat, Université Laval
Team Members:
  • Jean-Pierre Julien, Université Laval
  • François Berthod, CRCHUQ, Enfant-Jesus, University Laval
  • Sébastien Hébert, CHUQ Research Centre, Laval University
  • Mohamed Chahine, Institut de recherche en santé mentale de Québec, University Laval
  • François Gros-Louis, CRCHUQ-Enfant-Jesus, University Laval
  • Jacques P Tremblay, CHUQ Research Centre, Laval University
  • Michel Maziade, Institut de recherche en santé mentale de Québec, University Laval
  • Francesca Cicchetti, CHUQ Research Centre, Laval University
  • Nicolas Dupré, CRCHUQ-Enfant-Jesus, University Laval
  • Sachikko Sato, CHUQ Research Centre, Laval University
  • Solange Landreville, CRCHUQ-St Sacrement, University Laval
  • Edward Fon, McGill University