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Our directory of funded grants

364 result(s) found

Comprehensive Analysis Platform To Understand, Remedy and Eliminate ALS

Project Overview

Amyotrophic lateral sclerosis (ALS) is a terminal disease that paralyzes people because the brain is no longer able to communicate with the muscles that we are typically able to move at will. One of the challenges is that ALS is a very heterogeneous disease, meaning that each person’s disease is d…

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Principal Investigator:
  • Sanjay Kalra, University of Alberta
Team Members:
  • Nicolas Dupré, CRCHUQ-Enfant-Jesus, University Laval
  • Angela Genge, McGill University
  • Lorne Zinman, Sunnybrook Research Institute
  • Janice Robertson, University of Toronto
  • Christine Vande Velde, Université de Montréal
  • Ekaterina Rogaeva, University of Toronto
  • Tania Bubela, Simon Fraser University
  • Russell Greiner, University of Alberta
  • Wendy Johnston, University of Alberta

Correction of Neuronal Function in Autism

Project Overview

The prevalence of autism spectrum disorders (ASDs) is rising dramatically on a yearly basis and new interventional strategies are required to treat ASDs and related disorders like Fragile X syndrome. Altered communication between brain cells may lead to the defects responsible for the features that …

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Principal Investigator:
  • Laurie Doering, McMaster University
Team Members:
  • Min Zhuo, University of Toronto
  • Ali Pejmun Haghighi, McGill University
  • David Nelson, Baylor College of Medicine

Cortical GABAergic interneurons migration impairment in genetic epileptic encephalopathies

Project Overview

This project aims at elucidating the roles of new candidate genes in brain development, particularly in the context of refractory paediatric epilepsies (epileptic encephalopathies) and co-morbid neurodevelopmental disorders such as autism and intellectual deficiency.  Lara Eid is particularly inter…

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Principal Investigator:
  • Lara Eid, CHU-Saint Justine

CRF receptor-mediated sensitization of 5-HT2A receptor signalling

Project Overview

Anxiety and depression often present as co-morbid disorders and the expression and severity of these illnesses is commonly associated with stressful experiences. Both are widespread and serious disorders that affect the lives of 10-15% of Canadians for most of their lifetime. There are multiple pote…

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Principal Investigator:
  • Cornelia Walther, University of Western Ontario

Crosstalk between immune response and metabolic signaling: targeting leptin/AMPK axis to restore metabolic homeostasis in ALS

Project Overview

Increased metabolism (hypermetabolism) is a characteristic often associated with more aggressive, faster progressing cases of ALS. Recently, after studying blood plasma samples from people with more rapidly progressing disease, Dr. Jasna Kriz discovered that fast progressing individuals often have d…

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Principal Investigator:
  • Jasna Kriz, Université Laval
Team Members:
  • Nicolas Dupré, CRCHUQ-Enfant-Jesus, University Laval
  • Angela Genge, McGill University

Cyto-iGluSnFR: A glutamate biosensor platform for brain diseases

Project Overview

In the human brain and retina, the chemical glutamate is a very important messenger that carries information from one neuron to another. The levels of glutamate transmitted between neurons must be tightly controlled: too high and neurons die, too low and information is not communicated properly. In …

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Principal Investigator:
  • Don van Meyel, Research Institute of the McGill University Health Centre
Team Members:
  • Keith Murai, Research Institute of the McGill University Health Centre
  • Adriana Di Polo, CHUM Research Centre, University of Montréal
  • Tim Murphy, University of British Columbia

Cytosolic DNA sensing in ALS-related neuroinflammation

Project Overview

Recently, Dr. Honglin Luo, in collaboration with Dr. Neil Cashman, discovered that mutations in the ALS-linked SOD1 gene result in activation of a specific neuroinflammatory pathway called cGAS-STING. Neuroinflammation is thought to play an important role in the progression of ALS and activation of …

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Principal Investigator:
  • Honglin Luo, University of British Columbia
Team Members:
  • Neil Cashman, University of British Columbia

Deciphering eEF2K biological functions for therapeutic targeting of neural tumours

Project Overview

In childhood, medulloblastoma (a form of brain cancer) and neuroblastoma (a cancer that starts in the nerve cells) can be aggressive and hard to treat. Dr Poul Sorensen’s group is targeting what he believes is the Achilles heel of tumour cells: namely, how they adapt and survive under stress. He h…

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Principal Investigator:
  • Poul Sorensen, University of British Columbia

Decoding motor cortex circuit abnormalities at ALS onset through combined two-photon imaging in vivo and pharmacogenetics

Project Overview

ALS is a disease that is characterized by degeneration of both upper and lower motor neurons, and while a significant proportion of work has focused on motor neurons in the spinal cord, the motor cortex in the brain, where electrical signals to your muscles originate have clear, but poorly understoo…

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Principal Investigator:
  • Lisa Topolnik,

    CHUL, Université Laval

Decoding the RNA stability programs that determine cell identity and function in human brain and neurodegenerative disorders

Project Overview

The brain cells in Alzheimer’s disease patients differ extensively from healthy brain cells at the molecular level: there are hundreds of genes that are normally active in the brain, but become inactive in Alzheimer’s. Similarly, Alzheimer’s disease appears to turn on hundreds of genes that ar…

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Principal Investigator:
  • Hamed Najafabadi, McGill University

Defining conserved functions of RNA binding proteins in stress-granule biogenesis

Project Overview

RNA is a mobile form of genetic information that is made from our DNA and its complex regulation is extremely important to the proper functioning of our cells. Since the discovery of TDP-43 in 2006 as a substance that plays a major role in ALS, the hypothesis that abnormal regulation of RNA is criti…

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Principal Investigator:
  • Eric Lecuyer, Institut de Recherches Cliniques de Montréal, Université de Montréal

Defining the mechanism of inhibition of tau aggregation by the molecular chaperone, DNAJA2

Project Overview

Alzheimer’s Disease is a progressive and fatal disease that currently afflicts up to 400,000 Canadians over the age of 65. One key observation about this disease is that there is an abnormal “clumping” (aggregation) of specific proteins such as tau. Proteins normally need to keep a certain sha…

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Principal Investigator:
  • Sue-Ann Mok, University of Alberta

Detecting Behaviours of Risk in Nursing Homes using Deep Learning

Project Overview

Alzheimer’s Association International Research Grant Program: Alzheimer’s Association Research Grant (AARG) The main research question is to develop algorithms to detect behaviours of risk from videos recorded in the common area of a dementia care unit. People with dementia can have changes in j…

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Principal Investigator:
  • Shehroz Khan, University Health Network

Detection and prevention of pypermutant glioma in children and young adults

Project Overview

Need for project: Replication repair deficiency (RRD) is a genetic condition that significantly increases the risk of developing cancer, particularly early in life. Gliomas are the most common brain tumour seen in children and young adults (CAYA), and occur frequently in RRD. Currently, the prevalen…

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Principal Investigator:
  • Uri Tabori, The Hospital For Sick Children
Team Members:
  • Cynthia Hawkins, The Hospital For Sick Children
  • Jane Barron, Memorial University
  • Sunit Das, St. Michael's Hospital
  • Sidney E. Croul, Dalhousie University
  • Birgit Ertl-Wagner, The Hospital for Sick Children
  • Andrew Gao, University Health Network
  • Normand J Laperriere, Princess Margaret Cancer Centre
  • Julia Keith, Sunnybrook Health Sciences Centre
  • Farzad Khalvati, The Hospital for Sick Children
  • Derek Tsang, Princess Margaret Cancer Centre - UHN

Detection of misfolded TDP-43 in CSF of ALS cases: Diagnostic potential of confirmation-specific antibodies

Project Overview

A more streamlined way to diagnose ALS earlier is desperately needed as current methods can take up to two years and rely heavily on ruling out other conditions that share similar symptoms. One of the hallmarks of ALS for 97 per cent of cases is the accumulation of misfolded TDP-43 protein in motor …

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Principal Investigator:
  • Yulong Sun, University Health Network (University of Toronto)

Detection of tandem repeat expansion in neurological disorders

Project Overview

In the past decade, rapid development of software has allowed detection of a wide variety of genetic risk factors in brain disorders. It has improved clinical diagnosis and gene discovery for numerous human brain disorders. However, the casual genetic risk factors identified so far generally confer …

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Principal Investigator:
  • Ryan Yuen, The Hospital for Sick Children

Determination of hypothalamic neuropathology and metabolic defects in ALS

Project Overview

Amyotrophic lateral sclerosis (ALS) is a motor neuron disease leading to paralysis and death within 2-5 years from disease onset. Other hallmark features include weight loss and metabolic dysfunction. Several lines of clinical evidence indicated that higher energy expenditure (hypermetabolism) is as…

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Principal Investigator:
  • Jeehye Park,

    SickKids

Team Members:
  • Hoon-Ki Sung, University of Toronto

Development and validation of reagent kits for commercial high-throughput screening of PPI s and PPI inhibitors

Project Overview

Membrane proteins, which make up approximately one-third of all proteins in a cell, are responsible for a variety of processes, making them attractive therapeutic targets for many diseases such as hypertension, diabetes, neurological disorders and cancer. Understanding membrane protein function depe…

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Principal Investigator:
  • Igor Stagljar, University of Toronto

Development of a caregiver reported and weighted dementia outcome

Project Overview

Caregivers of people living with dementia know the person the best and have direct experience of how their partner’s dementia is progressing. Their experiences are pivotal in judging the real-world benefits of treatment and making decisions to keep the person at home or consider different levels o…

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Principal Investigator:
  • Ayse Kuspinar, McMaster University