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552 results found

An interdisciplinary approach to mindfulness as a quality of life improvement factor for people with ALS and their primary caregivers

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2021

  • Total Grant Amount

    $121,950

  • Health Canada Contribution

    $60,975

Project Overview

Amyotrophic Lateral Sclerosis (ALS) is very much a disease of losses and adjustments. People diagnosed with this disease face a higher than normal amount of anticipatory grief specific to lost abilities, lifestyles, skill sets, social interaction and life. The need to readjust, grieve and reinvent oneself in the face of…

Project Ongoing

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Modulating the ALS-associated C9orf72 repeat expansion in a murine model for therapeutic benefit

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Ontario

  • Start Date

    2021

  • Total Grant Amount

    $125,000

  • Health Canada Contribution

    $62,500

Project Overview

Mutations in a gene called C9ORF72 are the most common genetic cause of ALS. These mutations are unique in that unlike most other ALS-linked genes, where there is often a mistake in a single piece of DNA, C9ORF72 mutations involve a section of DNA that is abnormally repeated hundreds or…

Project Ongoing

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Investigating the role of mutations in CHCHD10 using ALS cell and zebrafish genetic models

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2021

  • Total Grant Amount

    $125,000

  • Health Canada Contribution

    $62,500

Project Overview

CHCHD10 is a nuclear encoded mitochondrial protein of the twin Cx9C family whose cellular function remains to be fully understood. Several dominantly inherited missense mutations have been reported in patients with amyotrophic lateral sclerosis (ALS), some of which appear to be gain of function while others are haploinsufficient. In the…

Project Ongoing

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Advanced pharmacokinetics and pharmacodynamics for phase Ib/IIa trial of repurposed enoxacin therapy for patients with ALS

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2021

  • Total Grant Amount

    $125,000

  • Health Canada Contribution

    $62,500

Project Overview

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease, primarily affecting motor neurons, for which there are currently no adequately effective therapies. It is therefore imperative that clinical trials investigating the safety and efficacy of potential therapies be well designed and provide as much critical information as possible to the…

Project Ongoing

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Causal tests of the hippocampal circuits mediating neural and behavioral pattern completion

  • Program Type

    Capacity building grants

  • Area of research

    Central Nervous System

  • Disease Area

    Other

  • Competition

    Future Leaders in Canadian Brain Research

  • Province

    Québec

  • Start Date

    2020

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

Most people have experienced the recollection of a vivid memory after encountering a trigger, such as a familiar place, object, or smell. In neuroscience, this process is called 'pattern completion'. For years people have thought that a particular part of the brain, called the ‘trisynaptic circuit’ of the hippocampus, might…

Project Ongoing

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