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551 results found

Modulating the ALS-associated C9orf72 repeat expansion in a murine model for therapeutic benefit

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Ontario

  • Start Date

    2021

  • Total Grant Amount

    $125,000

  • Health Canada Contribution

    $62,500

Project Overview

Mutations in a gene called C9ORF72 are the most common genetic cause of ALS. These mutations are unique in that unlike most other ALS-linked genes, where there is often a mistake in a single piece of DNA, C9ORF72 mutations involve a section of DNA that is abnormally repeated hundreds or…

Project Ongoing

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Investigating the role of mutations in CHCHD10 using ALS cell and zebrafish genetic models

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2021

  • Total Grant Amount

    $125,000

  • Health Canada Contribution

    $62,500

Project Overview

CHCHD10 is a nuclear encoded mitochondrial protein of the twin Cx9C family whose cellular function remains to be fully understood. Several dominantly inherited missense mutations have been reported in patients with amyotrophic lateral sclerosis (ALS), some of which appear to be gain of function while others are haploinsufficient. In the…

Project Ongoing

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Advanced pharmacokinetics and pharmacodynamics for phase Ib/IIa trial of repurposed enoxacin therapy for patients with ALS

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2021

  • Total Grant Amount

    $125,000

  • Health Canada Contribution

    $62,500

Project Overview

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease, primarily affecting motor neurons, for which there are currently no adequately effective therapies. It is therefore imperative that clinical trials investigating the safety and efficacy of potential therapies be well designed and provide as much critical information as possible to the…

Project Ongoing

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Causal tests of the hippocampal circuits mediating neural and behavioral pattern completion

  • Program Type

    Capacity building grants

  • Area of research

    Central Nervous System

  • Disease Area

    Other

  • Competition

    Future Leaders in Canadian Brain Research

  • Province

    Québec

  • Start Date

    2020

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

Most people have experienced the recollection of a vivid memory after encountering a trigger, such as a familiar place, object, or smell. In neuroscience, this process is called 'pattern completion'. For years people have thought that a particular part of the brain, called the ‘trisynaptic circuit’ of the hippocampus, might…

Project Ongoing

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The cell-type-specific organization and operation of the living human subiculum in health and epilepsy

  • Program Type

    Capacity building grants

  • Area of research

    Injury

  • Disease Area

    Epilepsy

  • Competition

    Future Leaders in Canadian Brain Research

  • Province

    British Columbia

  • Start Date

    2020

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

The hippocampus is a brain region critical for learning, memory, spatial navigation and emotion. The main output of the hippocampus is termed the “subiculum”, and is responsible delivering hippocampal output to a host of other brain regions. As such, the subiculum is powerfully situated to brain activity in healthy conditions,…

Project Complete

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