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Our directory of funded grants

254 result(s) found

Human MiniPromoters for Restricted Expression of Ocular Gene Therapy

Project Overview

The purpose of this project is to develop promoters. Promoters are pieces of DNA, which act as switches to turn genes on and off. Such promoters are important tools for drug companies working on developing gene-based therapies; known as gene therapies. These are a type of biological therapy, somewha…

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Principal Investigator:
  • Elizabeth Simpson, University of British Columbia
Team Members:
  • Adriana Di Polo, CHUM Research Centre, University of Montréal

Humans and the Microbiome

Project Overview

The CIFAR Humans & the Microbiome program brings together 21 researchers to examine what consciousness is and how it comes about. The program is part of the Canadian Institute for Advanced Research, which was founded in 1982 to bring together researchers from across disciplines and borders to addres…

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Principal Investigator:
  • Brett Finlay, University of British Columbia
  • Janet Rossant, The Hospital For Sick Children
Team Members:
  • Thomas Bosch, Universität Kiel
  • Tamara Giles-Vernick, Institut Pasteur
  • Philippe Gros, McGill University
  • Karen Guillemin, University of Oregon
  • Frédéric Keck, Musée du quai de Branly
  • Sven Pettersson, Karolinska Institutet
  • Tobias Rees, McGill University
  • Philippe Sansonetti, Institut Pasteur
  • Margaret Lock, McGill University

Identification of Brain Metastasis Initiating Cells and Regulators of Brain Metastasis from Lung Cancer

Project Overview

Ms. Singh’s project investigates brain metastases (BMs) – the most frequent type of brain tumour to occur in adults. The specific goals of her project include functional characterization of BMIC regulatory genes using a new human-mouse BMIC xenograft model, predictive signatures for patients wit…

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Principal Investigator:
  • Mohini Singh, McMaster University

Identification of circulating non-coding RNAs with diagnostic relevance in ALS patients using a unique extracellular vesicle capture method

Project Overview

Earlier diagnosis of ALS remains one of the biggest goals of researchers worldwide and it is likely that the effectiveness of future treatment discoveries will be magnified by their application at a time point closer to symptom onset. To date, achieving a definitive diagnosis of ALS often remains a …

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Principal Investigator:
  • Pier Jr Morin, Université de Moncton

Identification of novel genes causing intracranial aneurysms

Project Overview

Stroke is the leading cause of disability among adults and one of the three leading causes of death in North America. Intracranial aneurysm (IA) is one of the main subtypes of stroke and is a medical condition where the wall of a vessel in the brain expands, and fills with blood. If an IA bursts, it…

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Principal Investigator:
  • Michael Woods, Memorial University of Newfoundland
Team Members:
  • Ross McGowan, Memorial University of Newfoundland

Immunotherapy as a targeted low-impact treatment of paediatric brain cancers

Project Overview

Laura Donovan is investigating the use of Chimeric Antigen Receptor (CAR)-armed T cell based therapy as a potent and specific immunotherapy against paediatric medulloblastoma and ependymoma, by utilizing elegant in vivo and in vitro multimodal systems. Her research could significantly influence the …

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Principal Investigator:
  • Laura Donovan, The Hospital For Sick Children

Impaired Neuromuscular Junction Connectivity in Amyotrophic Lateral Sclerosis

Project Overview

Many scientists believe that one of the earliest abnormalities in ALS is dysfunction at the place where motor neurons connect to muscle, known as the neuromuscular junction (NMJ). Dr. Charles Krieger has observed that a substance called adducin, which is critical to the structure of the NMJ, is alte…

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Principal Investigator:
  • Charles Krieger, Simon Fraser University

Impaired translational regulation of brain development in autism spectrum disorders

Project Overview

Autism spectrum disorders (ASDs) are a group of complex neurodevelopmental disorders with distinguished early emerging behavioral disruptions (speech impairments, social communication, repetitive behaviors) and a rising rate of diagnosis to an estimated 1 in 68 children. Synaptogenesis occurs in the…

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Principal Investigator:
  • Jelena Popic, McGill University

Implementation of a Clinical Pathway for Acute Care of Pediatric Concussion: Uptake, Outcomes, and Health Care Impacts

Project Overview

Each year, 1-2 million children in North America suffer a concussion. Guidelines exist to manage the care of concussion in children but have not been implemented consistently. As a result, clinical practice varies widely from one health provider to another. This may be because clinical guidelines ha…

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Principal Investigator:
  • Keith Yeates, Hotchkiss Brain Institute, University of Calgary
Team Members:
  • Kathryn Schneider, University of Calgary
  • David Johnson, University of Calgary
  • Roger Zemek, Children’s Hospital of Eastern Ontario (CHEO)
  • Bruce Wright, University of Alberta
  • Brenda Clark, University of Alberta
  • Angelo Mikrogianakis, University of Calgary
  • Karen Barlow, Alberta Children's Hospital Research Institute
  • Alf Conradi, Stollery Children's Hospital
  • Alberto Nettel-Aguirre, The Governors of The University of Calgary

Improving Quality of Life in the Elderly by Standardizing Care for Neuropsychiatric Symptoms of Dementia

Project Overview

Aggression and agitation are common symptoms among patients with dementia. These symptoms are the leading cause for hospitalization and admission to long-term care homes. Medication treatments that are commonly used to treat these symptoms have significant adverse effects including falls, stroke and…

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Principal Investigator:
  • Tarek Rajji, Centre for Addiction and Mental Health
Team Members:
  • Amer Burhan, London Health Sciences Centre
  • Simon Davies, Centre for Addiction and Mental Health
  • Philip Gerretsen, Centre for Addiction and Mental Health
  • Ariel Graff, Centre for Addiction and Mental Health
  • Zahinoor Ismail, University of Calgary
  • Sanjeev Kumar, Centre for Addiction and Mental Health
  • Paul Kurdyak, Centre for Addiction and Mental Health
  • Benoit Mulsant, CAMH, University of Toronto
  • Vasavan Nair, Douglas Hospital Research Centre
  • Bruce Pollock, Centre for Addiction and Mental Health
  • Claire de Oliveira, Centre for Addiction and Mental Health

In utero exposure to glucocorticoids in humans and an animal model: Epigenetic and transcriptional signatures

Project Overview

This project will study blood obtained from babies shortly after birth and in guinea pigs early in life to discover how genes throughout the genome respond to glucocorticoid treatment. This research has important implications for the fundamental understanding of biological responses to glucocortico…

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Principal Investigator:
  • Aya Sasaki, University of Toronto

In vitro and in vivo functional assessment of neuropsychiatric disease-related synaptic gene mutations

Project Overview

Dr. Xie’s research focuses on the functional assessment of neuropsychiatric disease related synaptic genes – MDGA1 and 2. MDGAs bind to critical neuron synaptic proteins – Neuroglin (NLGN), disrupting the binding between NLGN and Neurexin (NRXN), so suppressing synaptogenesis. Mutations (misse…

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Principal Investigator:
  • Yicheng Xie, Brain Research Centre, University of British Columbia

Integrated Neurostimulation Platform for Neuropsychiatric Research

Project Overview

The Integrated Neurostimulation Platform for Neuropsychiatric Research offers the capacity to perform interleaved TMS/fMRI, a complex and demanding technique used to study brain function in neuropsychiatric disorders. The academic home for the platform is the Djavad Mowafaghian Centre for Brain Heal…

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Principal Investigator:
  • Fidel Vila-Rodriguez, University of British Columbia
Team Members:
  • Lara Boyd, University of British Columbia
  • Ray Lam, University of British Columbia
  • William Honer, University of British Columbia
  • Ivan Torres, University of British Columbia
  • Mario Liotti, Simon Fraser University
  • Alex MacKay, University of British Columbia
  • Jon Stoessl, University of British Columbia
  • Doris Doudet, Univeristy of British Columbia

Integrative discovery of ion channels as drug targets in glioblastoma

Project Overview

Ion channel (IC) proteins are known to be involved in different human diseases such as heart and brain disorders. There are many drugs that activate or inactivate ICs and they are used to treat patients with these diseases. However, less has been known about the role of ICs in cancer and no approved…

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Principal Investigator:
  • Juri Reimand, Ontario Institute for Cancer Research

Interleukin-1 blockade along with hypothermia to prevent cerebral palsy arising from refractory neonatal asphyxia

Project Overview

Neonatal asphyxia and subsequent cerebral palsy (CP) is a severe pathology resulting from lack of oxygen and/or infection-inflammation. This disease still leads to mortality or severe brain injuries and long-term disabilities. Therapeutic hypothermia (decreased body temperature to 33-34°C during 3 …

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Principal Investigator:
  • Mathilde Chevin, McGill University Health Centre

Investigating Blood Brain Barrier Permeability in an Experimental Model of Juvenile Stroke Using Advanced MR Imaging

Project Overview

Stroke is one of the leading causes of cerebral palsy in children that carried to term, and 60% have lifelong consequences.  Currently, treatment of childhood stroke is limited to prevention of more strokes.  Dr. Domi’s research uses specialized imaging techniques to study the role of the blood-…

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Principal Investigator:
  • Trish Domi, University of Toronto

Investigating the effects of C9orf72 haploinsufficiency on TDP-43 pathology in ALS

Project Overview

Normal cells have a “self-cleaning” process called autophagy that breaks down and clears out cellular waste, so the cell can function properly. In the majority of ALS cases, a protein known as TDP-43 becomes misfolded and accumulates in motor neurons, causing toxicity. The accumulation of misfol…

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Principal Investigator:
  • Lilian Lin, University of Toronto

Investigation of microbiota mediated suppression of motor neuron degeneration in genetic models of ALS

Project Overview

Scientists have long wondered what the contribution of environment is to ALS and in recent years the idea that a combination of genetic susceptibility and environmental triggers has taken shape. Furthermore, one of the emerging areas of interest for environmental exposure is the gastrointestinal tra…

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Principal Investigator:
  • Alex Parker,

    Centre hospitalier de l'Université de Montréal

Investigation of the innate immune system and motor neuron degeneration in genetic models of ALS

Project Overview

In recent years, it was discovered that a microscopic worm called C. elegans could mimic some of the aspects of human ALS when they were engineered to have abnormal (mutant) genes that cause the disease. Not only do they have motor neuron degeneration like humans, but the worms experience paralysis.…

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Principal Investigator:
  • Alex Parker,

    Centre hospitalier de l'Université de Montréal

Le Consortium d’Imagerie en Neurosciences et santé mentale de Québec: leader régional en neuroimagerie humaine

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Principal Investigator:
  • Pascale Tremblay, Université Laval
Team Members:
  • Philip Jackson, Université Laval
  • Catherine Mercier, Université Laval
  • Cyril Scheider, Université Laval
  • Amélie Achim, Université Laval
  • Shirley Fecteau, Université Laval
  • Carol Hudon, Université Laval
  • Laura Monetta, Université Laval
  • Simon Duchesne, Université Laval
  • Maximiliano Wilson, Université Laval