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Our directory of funded grants

383 result(s) found

Does rehabilitation improve brain structure/function and motor outcomes of children with developmental coordination disorder?

Project Overview

Ms. Izadi-Najafabadi’s research focuses on the effect of Cognitive Orientation to Occupational Performance (CO-OP)—the current best-practiced intervention for children with Developmental Coordination Disorder (DCD)—on their structural and functional brain connectivity. This study also explores…

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Principal Investigator:
  • Sara Izadi-Najafabadi, Brain Research Centre, University of British Columbia

Dopaminergic modulation of stroke recovery

Project Overview

Strokes often cause brain damage that affects normal cognitive and sensorimotor functions. The brain has the extraordinary ability to adapt by forming new circuits which can, to some extent, compensate for neuronal loss. The recovery of motor function can be improved by rehabilitation exercises aime…

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Principal Investigator:
  • Christian Ethier, Université Laval

Douglas-Bell Canada Brain Bank, an essential platform for brain research in Canada

Project Overview

The Douglas-Bell Canada Brain Bank (DBCBB) houses and manages over 3,000 brains, as well as a large relational database containing demographic, clinical and developmental histories from the donors. The DBCBB is one of the rare brain banks in the world to collect brains from people who suffered from …

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Principal Investigator:
  • Gustavo Turecki, Douglas Hospital Research Centre
Team Members:
  • Naguib Mechawar, Douglas Mental Health University Institute
  • Michael J. Meaney, Douglas Mental Health University Institute
  • Guy Rouleau, Montreal Neurological Hospital and Institute
  • Michael Kobor, University of British Columbia
  • Martin Alda, Dalhousie University
  • Paul R. Albert, Ottawa Hospital Research Institute
  • Cathy Barr, Toronto Western Hospital
  • Darrell Mousseau, University of Saskatchewan
  • Satyabrata Kar, University of Alberta
  • Shimon Amir, Concordia University
  • Ana Andreazza, Centre for Addiction and Mental Health
  • Gilbert Bernier, Research Centre, Maisonneuve-Rosemont Hospital
  • Diane Boivin, Douglas Mental Health University Institute
  • Bernard Brais, Montreal Neurological Hospital and Institute
  • Nicolas Cermakian, Douglas Mental Health University Institute
  • Balu Chakravarthy, Carleton University
  • Cletus D’Souza, BC Cancer Agency
  • Salah El Mestikawy, Douglas Mental Health University Institute
  • Carl Ernst, Douglas Mental Health University Institute
  • Ken Evans, Queen's University
  • Harriet Feilotter, Queen's University
  • Nicolas Flamand, Institut Universitaire de Cardiologie et Pneumologie de Quebec, Laval University
  • Cecilia Flores, Douglas Mental Health University Institute
  • David Fortin, Université de Sherbrooke
  • Edith Hamel, Montreal Neurological Hospital and Institute
  • Michael R. Hayden, University of British Columbia
  • Sébastien Hébert, CHUQ Research Centre, Laval University
  • Martin Hirst, BC Cancer Agency
  • Jack Jhamandas, University of Alberta
  • Sidney H. Kennedy, University Health Network
  • Christine Lavoie, Université de Sherbrooke
  • Marco Marra, BC Cancer Agency
  • Anne McKinney, McGill University
  • Daniel Mueller, Centre for Addiction and Mental Health
  • Gerhard Multhaup, McGill University
  • Lisa Münter, McGill University
  • Art Petronis, University of Toronto/CAMH
  • Bruce Pike, Montreal Neurological Hospital and Institute
  • Judes Poirier, Douglas Mental Health University Institute
  • Alexandre Prat, CHUM Research Centre, University of Montréal
  • Rémi Quirion, Douglas Mental Health University Institute
  • Pedro Rosa-Neto, Douglas Mental Health University Institute
  • Xavier Roucou, Université de Sherbrooke
  • Elizabeth Simpson, University of British Columbia
  • Abbas Sadikot, Montreal Neurological Hospital and Institute
  • Lalit Srivastava, Douglas Mental Health University Institute
  • Moshe Szyf, McGill University
  • Derek van der Kooy, University of Toronto
  • Christine Vande Velde, Université de Montréal
  • Lan Xiong, CHUM Research Centre, University of Montréal
  • L. Trevor Young, Centre for Addiction and Mental Health

Drug Delivery across the Human Blood-Brain Barrier

Project Overview

Toxic amyloid proteins are known to be a significant contributing factor in the development of Alzheimer’s disease. Abnormal clusters of protein fragments build up between nerve cells in the brainleading to impaired memory. The most important therapies in development currently are biologics, antib…

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Principal Investigator:
  • Nathan Yoganathan, KalGene Pharmaceuticals Inc
Team Members:
  • Louis Collins, McGill University
  • Jean-Paul Soucy, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University
  • Danica Stanimirovic, National Research Council of Canada
  • Balu Chakravarthy, Carleton University
  • Pedro Rosa-Neto, Douglas Mental Health University Institute

Drug repurposing in medulloblastoma using integrated functional genomic, epigenomic, and transcriptomic approaches

Project Overview

The project conducted by Dr. Gendoo is focused upon identifying potential therapeutic targets against Medulloblastoma (MB) subtypes. Identification of subtype-specific therapies is contingent upon: 1) proper classification of samples into MB subtypes; and 2) proper understanding of the pharmacologic…

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Principal Investigator:
  • Deena Gendoo, The Hospital For Sick Children

Dysregulation of integrated stress response (ISR) pathway in Fragile X syndrome and autism

Project Overview

This project is focused on role of the integrated stress response (ISR) pathway in fragile X syndrome as well as autism.  Mehdi Hooshmandi is aiming to figure out the exact ISR pathway abnormalities in different cell types and regions of the brain. Once the altered molecule(s) is identified, it wil…

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Principal Investigator:
  • Mehdi Hooshmandi, McGill University

Early Brain Development Following Prenatal Exposure to SSRI Antidepressants and Maternal Depression

Project Overview

Many women experience depression during pregnancy, and are often faced with challenging decisions surrounding antidepressant use during this critical time for their developing child. Fetal exposure to maternal antidepressant use is poorly understood, and further, the effects are often lef…

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Principal Investigator:
  • Kayleigh Campbell, BCCHR

Early diagnosis of gliomas by using a novel multiplexed serum proteomic technology

Project Overview

Need for project: Gliomas are among the most malignant tumors, with very poor survival rates. Early diagnosis is highly desirable since it can facilitate more effective treatments of small tumors, which have not as yet extensively metastasized. It is thus of upmost importance to find non-invasive bi…

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Principal Investigator:
  • Eleftherios Diamandis, Lunenfeld-Tanenbaum Research Institute
Team Members:
  • Douglas Fraser, Children’s Health Research Institute
  • Maxime Richer, Université de Sherbrooke

Early Postnatal Metabolic Treatment for the Fetal Alcohol Syndrome

Project Overview

Fetal Alcohol Syndrome (FAS) is the result of in utero alcohol exposure and is characterized by central nervous system developmental impairments which causes lifelong physical and cognitive disabilities. The mechanisms of the impaired brain development are poorly understood, but they seem to be rela…

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Principal Investigator:
  • Paolo Bazzigaluppi, Toronto Western Hospital

Early Years Intervention on a First Nations Reserve

Project Overview

Recognizing that the 9 months before birth and the early years of a child’s life are the most critical period in the shaping of the structures and functions of the brain, and the importance of high quality, culturally appropriate early childhood programming for Indigenous children and families pri…

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Principal Investigator:
  • Bryan Kolb, University of Lethbridge
  • Melissa Tremblay, University of Alberta

Effects of C9orf72 Deficiency on Inducing Neuronal Hyperexcitability In Vivo

Project Overview

A G4C2 repeat expansion in C9orf72 (chromosome 9 open reading frame 72), a gene of unclear function, is the most frequent genetic cause of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (C9-ALS/FTD). The repeat expansions cause transcriptional downregulation of the C9orf72 mRNA resu…

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Principal Investigator:
  • Janice Robertson, University of Toronto
Team Members:
  • Liang Zhang, University of Toronto

Effects of Sex Hormone Therapy on Brain Development in Adolescents Experiencing Gender Dysphoria: A Magnetic Resonance Imaging Study

Project Overview

Adolescence is a time of rapid brain maturation that is partly influenced by sex hormones. In this project, magnetic resonance imaging will be used to assess the influence of sex hormones on brain structure and function. Malvina Skorska will examine how the brain structure and function of adolescent…

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Principal Investigator:
  • Malvina Skorska, University of Toronto

Electrically guided transcranial stimulation of cells chemogenically primed for excitability a novel, non-invasive and cell type-specific approach

Project Overview

I propose to test a new and potentially groundbreaking experimental technique called EC stimulation, which will enable researchers to influence the activity of different kinds of neurons in any part of the brain without the need of major brain invasive surgery or complex genetic techniques. This wil…

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Principal Investigator:
  • Francis Bambico, Memorial University of Newfoundland

Electrophysiological measures of proteinopathy in asymptomatic older adults

Project Overview

Alzheimer’s Association International Research Grant Program: Alzheimer’s Association Research Grant – New to the Field (AARG-NTF) Our project proposes the development and first-step validation of a new, noninvasive mapping procedure of proteinopathy in asymptomatic older adults. Our approach …

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Principal Investigator:
  • Sylvain Baillet, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University

EMPOW-HER: Exploring methods to improve participation of women in clinical trials to help enhance stroke recovery research

Project Overview

In general, women take part in research less than men. We found women take part in our research less than men too. We are a team of rehabilitation researchers located across Canada that test new treatments like drugs, technologies, and remote therapies on people who have had a stroke that could help…

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Principal Investigator:
  • Mark Bayley, Toronto Rehabilitation Institute
Team Members:
  • Janice Eng, University of British Columbia
  • Sandra Black, Sunnybrook Health Sciences Centre
  • Sean Dukelow, University of Calgary
  • Bradley MacIntosh, Sunnybrook Research Institute
  • Marilyn MacKay-Lyons, Dalhousie University
  • Michelle Ploughman, Memorial University of Newfoundland
  • Ada Tang, McMaster University
  • Robert Teasell, Parkwood Institute
  • Ruth Barclay, University of Manitoba
  • Farrell Leibovitch, Canadian Partnership for Stroke Recovery
  • Shannon MacDonald, University Health Network – Toronto Rehab
  • Susan Marzolini, University Health Network – Toronto Rehab
  • Jason McCarthy, Eastern Health Authority
  • Courtney Pollock, University of British Columbia
  • Sepideh Pooyania, Riverview Health Centre
  • Brodie Sakakibara, University of British Columbia
  • Amra Saric, Nova Scotia Rehabilitation Centre
  • Jennifer Yao, GF Strong
  • Amy Yu, Sunnybrook Health Sciences Centre

Enhancing the efficacy of heat shock protein inducers by cotreatment with a histone deacetylase inhibitor – A therapeutic strategy for ALS

Project Overview

In ALS and many other neurodegenerative diseases, one of the defining characteristics is that proteins can become misfolded and clump together, potentially damaging nerve cells. When a healthy body responds to stress, protective mechanisms increase the production of heat shock proteins that help pre…

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Principal Investigator:
  • Heather Durham, McGill University
Team Members:
  • Chantelle Sephton, Université Laval
  • Richard Robitaille, Université de Montréal
  • Josephine Nalbantoglu, McGill University

Epigenetic mechanisms underlying dendritic atrophy in ALS

Project Overview

Motor neurons are made up of three distinct regions. The top of the neuron is composed of branches like a tree called dendrites that receive information to transmit. The middle part of the neuron is called the cell body where the majority of the life processes occur and the bottom consists of a sing…

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Principal Investigator:
  • Heather Durham, McGill University

Epigenetics and mental health: the Canadian neuroepigenetics network

Project Overview

Psychiatry, like all areas of medicine and biology, has long considered the origins of individual differences. This issue ultimately produced a nature vs nurture schism that divided researchers who emphasized the importance of environmental influences from those who considered the importance of heri…

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Principal Investigator:
  • Michael J. Meaney, Douglas Mental Health University Institute
Team Members:
  • Paul R. Albert, Ottawa Hospital Research Institute
  • Guillaume Bourque, McGill University
  • Gustavo Turecki, Douglas Hospital Research Centre
  • Michael Kobor, University of British Columbia
  • Thomas Boyce, University of British Columbia
  • Joanna Holbrook, Singapore Institute for Clinical Sciences

Evaluating therapeutic stimulation in a mouse model of perinatal stroke

Project Overview

Neonatal strokes occur in approximately 1 in 1500 term births and is the leading cause of hemiplegic cerebral palsy (HCP). The ischemic event leaves most children with life-long motor impairments, and in many cases the effects of rehabilitation are minimal. One potential mechanism for further enhanc…

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Principal Investigator:
  • Greg Silasi, University of Ottawa

Evaluation of electrical activity as a tumour suppressor in medulloblastoma

Project Overview

Dr. Garzia works on a type of pediatric brain cancer called medulloblastoma. Kids affected by this tumor are either not cured or experience severe side effects due to the aggressive therapy. This proposal explores a possible causative link between altered neural activity and brain tumors. The team h…

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Principal Investigator:
  • Livia Garzia, McGill University Health Centre Research Institute (RI-MUHC)