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Our directory of funded grants

254 result(s) found

Learning in Machines and Brains

Project Overview

The program in Learning in Machines & Brains (formerly known as Neural Computation & Adaptive Perception) is revolutionizing the field of artificial intelligence, and creating computers that think more like us – that can recognize faces, understand what is happening in a picture or video, and comp…

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Principal Investigator:
  • Yoshua Bengio, Université de Montréal
Team Members:
  • Yann Lecun, Facebook AI Research
  • Francis Bach, Inria
  • Aaron Courville, Université de Montréal
  • Nando de Freitas, University of Oxford
  • James DiCarlo, Massachusetts Institute of Technology
  • David Fleet, University of Toronto
  • Brendan Frey, University of Toronto
  • Surya Ganguli, Stanford University
  • Zaid Harchaoui, Inria
  • Aapo Hyvarinen, University of Helsinki
  • Hugo Larochelle, Université de Sherbrooke
  • Honglak Lee, University of Michigan
  • Christopher Manning, Stanford University
  • Roland Memisevic, Université de Montréal
  • Andrew Ng, Stanford University
  • Bruno Olshausen, University of California, Berkeley
  • Ruslan Salakhutdinov, University of Toronto
  • Mark Schmidt, University of British Columbia
  • Eero Simoncelli, New York University
  • Josef Sivic, Inria
  • Ilya Sutskever, OpenAI
  • Richard Sutton, University of Alberta
  • Antonio Torralba, Massachusetts Institute of Technology
  • Pascal Vincent, Université de Montréal
  • Yair Weiss, The Hebrew University of Jerusalem
  • Max Welling, University of Amsterdam
  • Christopher Williams, The University of Edinburgh
  • Richard Zemel, University of Toronto

Locally produced brain insulin in memory and Alzheimer’s disease: A multi-disciplinary approach to a key question

Project Overview

One percent of Alzheimer’s disease is the early-onset type that runs in families. Extensive studies of these ultra-rare forms of Alzheimer’s disease have revealed the genes that cause them. On the other hand, the most common forms of Alzheimer’s disease are surprisingly understudied and poorly…

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Principal Investigator:
  • James Johnson, University of British Columbia
Team Members:
  • Paul Pavlidis, University of British Columbia
  • Shernaz Bamji, University of British Columbia

Making the race fair for young children at risk: a targeted prevention approach to reducing child emotional and behaviour problems

Project Overview

One of the largest predictors of mental illness is childhood emotional and behavioural problems (EBP, e.g., aggression, anxiety, depression), which occur in 12-26% of children under age 6 years. There is an urgent need for early interventions that prevent the onset of EBP in young children. For this…

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Principal Investigator:
  • Teresa Bennett, McMaster University
Team Members:
  • Katholiki Georgiades, McMaster University
  • Andrea Gonzalez, McMaster University
  • Ellen Lipman, McMaster University
  • Magdalena Janus, McMaster University
  • Charlotte Waddell, Simon Fraser University
  • John McLennan, University of Calgary
  • Michael Boyle, McMaster University
  • John Cairney, McMaster University
  • James Dunn, McMaster University

Manitoba Neuroimaging Platform

Project Overview

Complex research questions in neurology are often most effectively addressed by monitoring brain structure and function in human patients and live animals in experimental disease models.  Recent advances in radiology, computational analysis and medical physics have made it possible to accomplish th…

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Principal Investigator:
  • Christopher Anderson, University of Manitoba
Team Members:
  • Marco Essig, University of Manitoba
  • Ruth Ann Marrie, University of Manitoba
  • Chase Figley, University of Manitoba
  • Tamra Ogilvie, University of Manitoba
  • Soheila Karimi, University of Manitoba
  • Marc Del Bigio, University of Manitoba
  • Thomas Klonisch, University of Manitoba
  • Alan Mutch, University of Manitoba

Mapping the cellular origins of circuit vulnerability in neurodevelopmental disorders

Project Overview

The brain is an incredibly complex organ. Much of the brain’s complexity may be attributed to the circuitry that resides within. Synaptic connections are the key units of information transduction and therefore and therefore an increasing amount of research focus has centered on understanding how t…

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Principal Investigator:
  • Maxime Rousseaux, University of Ottawa

Maternal care and child neurodevelopment: A longitudinal gene x environment analysis of socio-emotional development with an integrated approach

Project Overview

Maternal depression, particularly during pregnancy, has been well established as a risk factor for child socio-emotional problems. However, the impact varies across the population, as some individuals are resilient. Their genetic architecture may hold the secrets to the differential susceptibility. …

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Principal Investigator:
  • Lawrence Chen, McGill University

Mechanisms of delayed death in stroke

Project Overview

Stroke is a major cause of death and disability. At present, there are no clear and effective therapies to aid the majority of patients who suffer stroke. The goals of the present research are to understand the stroke process and identify targets, which block brain cell death following an ischemic i…

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Principal Investigator:
  • David Park, University of Ottawa

Mechanisms of glutamatergic neuronal dysfunction in genetic models of ALS

Project Overview

This project will focus on comprehensively studying impaired transmission of signals (from the brain) at the location where neurons and muscles meet, called the neuromuscular junction.  Recent evidence from a number of labs has indicated that errors in neurotransmission of signals might be one of t…

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Principal Investigator:
  • Gary Armstrong,

    Montreal Neurological Institute, McGill University

Mechanisms of in vitro synaptic transmission of mis-folded human SOD1

Project Overview

The process by which ALS spreads throughout the body remains a mystery, but Dr. Neil Cashman has spent decades looking at how abnormal changes in shape (scientifically called misfolding) of crucial proteins (the substances that do life processes) in our cells might propagate disease from one cell to…

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Principal Investigator:
  • Neil Cashman, University of British Columbia

Mechanisms of Synaptic Dysfunction in Amyotrophic Lateral Sclerosis

Project Overview

This project will focus on unique roles of FUS (an ALS gene/protein) at the junction where neurons connect, called the synapse. Most of the work done on FUS focuses on its functions in the central region of the neuron called the cell body. When there is a mutation in the FUS gene, it causes ALS and …

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Principal Investigator:
  • Chantelle Sephton, Université Laval

Microfluidic Screening Technology for the Discovery of Function-Modifying Antibodies Against Membrane Protein Targets

Project Overview

Antibody (Ab)-based therapeutics are the fastest growing class of drugs, with approximately 60 approved molecules that represent a market of over $80B. To date, the growth of this market has been due to new therapeutics against targets that can be prepared as soluble antigens. Attention is now turni…

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Principal Investigator:
  • Carl Hansen, University of British Columbia

Misfolded SOD1 in ALS pathogenesis

Project Overview

The first genetic cause of ALS to be discovered (in 1993) encoded a mutation in protein called superoxide dismutase 1 (SOD1). Decades later, it is largely agreed upon that the abnormal shape (called misfolding) of SOD1 mutants is at the root of toxicity in some forms of ALS. Traditionally, misfolded…

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Principal Investigator:
  • Christine Vande Velde, Université de Montréal

Mitochondrial calcium uptake and targeted therapeutics

Project Overview

Stroke is the sudden death of brain cells caused by insufficient blood supply to the brain. Parts of the brain that enable us to walk and talk are often damaged most by a stroke. As a result, patients that survive a stroke frequently need assistance from others to take care of themselves. In these w…

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Principal Investigator:
  • George Robertson, Dalhousie University

Modulating memory circuits: focal DBS treatments to improve medial temporal lobe function

Project Overview

Two diseases that show very different trajectories have nevertheless led researchers to identify dysfunction in a common brain network. The diseases in question are Alzheimer’s disease, a devastating neurodegenerative disorder, and temporal lobe epilepsy, the most common type of partial-seizure ep…

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Principal Investigator:
  • Kari Hoffman, York University
Team Members:
  • Sylvain Williams, Douglas Mental Health University Institute
  • Taufik Valiante, University Health Network
  • Andres Lozano, University Health Network
  • Mallar Chakravarty,

    Douglas Mental Health University Institute

  • Jason Lerch, University of Toronto
  • Milos Popovic, University of Toronto