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545 results found

Mechanisms of response and resistance to Olaparib and Durvalumab in treatment of glioblastomas and IDH-mutated astrocytomas

  • Program Type

    Capacity building grants

  • Area of research

    Cancer

  • Disease Area

    Brain Cancer

  • Competition

    Henry and Berenice Kaufmann Foundation Trainee Award in Brain Cancer Research

  • Province

    Ontario

  • Start Date

    2023

  • Total Grant Amount

    $10,000

  • Health Canada Contribution

    $5,000

Project Overview

Glioblastoma multiforme and high grade astrocytomas are aggressive brain tumors that are difficult to treat. These tumors have genetic changes that affect their ability to repair DNA. Recent research has discovered that a combination of two drugs, Olaparib and Durvalumab, could be effective in treating these tumors. Olaparib blocks a…

Leveraging proximity interactomics to identify therapeutically targetable RNA-binding proteins in G4C2 repeat-driven ALS

  • Program Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    Pierre Auger Morissette Capacity-Building Award in ALS Research

  • Province

    Québec

  • Start Date

    2023

  • Total Grant Amount

    $7,500

  • Health Canada Contribution

    $3,750

Project Overview

Amyotrophic lateral sclerosis (ALS) is a progressive disease that causes loss of control over muscles and leads to death quickly after diagnosis. It remains incurable, with a subtype of ALS being commonly associated with a specific genetic mutation that causes a toxic RNA molecule to be produced. This repeat-containing RNA…

Investigating cerebellar Pathology in a zebrafish C9orf72 ALS model

  • Program Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    Pierre Auger Morissette Capacity-Building Award in ALS Research

  • Province

    Québec

  • Start Date

    2023

  • Total Grant Amount

    $7,500

  • Health Canada Contribution

    $3,750

Project Overview

Amyotrophic Lateral Sclerosis (ALS) is a rare and fatal disease, which is characterized by degeneration of specific neurons called “Motor neurons” that control the movement of our muscles. We are particularly interested in a specific gene called C9ORF72, which is found to be mutated in most of the ALS cases.…

Longitudinal Neurocognitive Trajectories in Perinatal Arterial Ischemic Stroke

  • Program Type

    Capacity building grants

  • Area of research

    Injury

  • Disease Area

    Stroke

  • Competition

    Dr. Matthew Galati Brain Changer Award

  • Province

    Ontario

  • Start Date

    2023

  • Total Grant Amount

    $10,000

  • Health Canada Contribution

    $5,000

Project Overview

The highest lifetime risk of stroke is the week surrounding birth, with perinatal arterial ischemic stroke (AIS) the most common stroke subtype during this period. Perinatal AIS is an acquired brain injury resulting in cerebrovascular insult to the developing brain; however, to date, there has been no longitudinal research to…

Mechanisms of Cognitive Impairment in Children Treated for Brain Tumors

  • Program Type

    Capacity building grants

  • Area of research

    Injury

  • Disease Area

    Stroke

  • Competition

    Dr. Matthew Galati Brain Changer Award

  • Province

    Ontario

  • Start Date

    2023

  • Total Grant Amount

    $12,000

  • Health Canada Contribution

    $6,000

Project Overview

In developed countries, brain tumors are the leading cause of disability and death among children. Treatment advances have improved survival rates, but survival comes at a cost for pediatric brain tumor survivors. Surgery and cranial radiotherapy are needed for cure but are both damaging to brain tissue – especially white…