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Our directory of funded grants

366 result(s) found

Early Years Intervention on a First Nations Reserve

Project Overview

Recognizing that the 9 months before birth and the early years of a child’s life are the most critical period in the shaping of the structures and functions of the brain, and the importance of high quality, culturally appropriate early childhood programming for Indigenous children and families pri…

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Principal Investigator:
  • Bryan Kolb, University of Lethbridge
  • Melissa Tremblay, University of Alberta

Effects of C9orf72 Deficiency on Inducing Neuronal Hyperexcitability In Vivo

Project Overview

A G4C2 repeat expansion in C9orf72 (chromosome 9 open reading frame 72), a gene of unclear function, is the most frequent genetic cause of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (C9-ALS/FTD). The repeat expansions cause transcriptional downregulation of the C9orf72 mRNA resu…

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Principal Investigator:
  • Janice Robertson, University of Toronto
Team Members:
  • Liang Zhang, University of Toronto

Effects of Sex Hormone Therapy on Brain Development in Adolescents Experiencing Gender Dysphoria: A Magnetic Resonance Imaging Study

Project Overview

Adolescence is a time of rapid brain maturation that is partly influenced by sex hormones. In this project, magnetic resonance imaging will be used to assess the influence of sex hormones on brain structure and function. Malvina Skorska will examine how the brain structure and function of adolescent…

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Principal Investigator:
  • Malvina Skorska, University of Toronto

Electrically guided transcranial stimulation of cells chemogenically primed for excitability a novel, non-invasive and cell type-specific approach

Project Overview

I propose to test a new and potentially groundbreaking experimental technique called EC stimulation, which will enable researchers to influence the activity of different kinds of neurons in any part of the brain without the need of major brain invasive surgery or complex genetic techniques. This wil…

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Principal Investigator:
  • Francis Bambico, Memorial University of Newfoundland

Electrophysiological measures of proteinopathy in asymptomatic older adults

Project Overview

Alzheimer’s Association International Research Grant Program: Alzheimer’s Association Research Grant – New to the Field (AARG-NTF) Our project proposes the development and first-step validation of a new, noninvasive mapping procedure of proteinopathy in asymptomatic older adults. Our approach …

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Principal Investigator:
  • Sylvain Baillet, McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University

EMPOW-HER: Exploring methods to improve participation of women in clinical trials to help enhance stroke recovery research

Project Overview

In general, women take part in research less than men. We found women take part in our research less than men too. We are a team of rehabilitation researchers located across Canada that test new treatments like drugs, technologies, and remote therapies on people who have had a stroke that could help…

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Principal Investigator:
  • Mark Bayley, Toronto Rehabilitation Institute
Team Members:
  • Janice Eng, University of British Columbia
  • Sandra Black, Sunnybrook Health Sciences Centre
  • Sean Dukelow, University of Calgary
  • Bradley MacIntosh, Sunnybrook Research Institute
  • Marilyn MacKay-Lyons, Dalhousie University
  • Michelle Ploughman, Memorial University of Newfoundland
  • Ada Tang, McMaster University
  • Robert Teasell, Parkwood Institute
  • Ruth Barclay, University of Manitoba
  • Farrell Leibovitch, Canadian Partnership for Stroke Recovery
  • Shannon MacDonald, University Health Network – Toronto Rehab
  • Susan Marzolini, University Health Network – Toronto Rehab
  • Jason McCarthy, Eastern Health Authority
  • Courtney Pollock, University of British Columbia
  • Sepideh Pooyania, Riverview Health Centre
  • Brodie Sakakibara, University of British Columbia
  • Amra Saric, Nova Scotia Rehabilitation Centre
  • Jennifer Yao, GF Strong
  • Amy Yu, Sunnybrook Health Sciences Centre

Enhancing the efficacy of heat shock protein inducers by cotreatment with a histone deacetylase inhibitor – A therapeutic strategy for ALS

Project Overview

In ALS and many other neurodegenerative diseases, one of the defining characteristics is that proteins can become misfolded and clump together, potentially damaging nerve cells. When a healthy body responds to stress, protective mechanisms increase the production of heat shock proteins that help pre…

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Principal Investigator:
  • Heather Durham, McGill University
Team Members:
  • Chantelle Sephton, Université Laval
  • Richard Robitaille, Université de Montréal
  • Josephine Nalbantoglu, McGill University

Epigenetic mechanisms underlying dendritic atrophy in ALS

Project Overview

Motor neurons are made up of three distinct regions. The top of the neuron is composed of branches like a tree called dendrites that receive information to transmit. The middle part of the neuron is called the cell body where the majority of the life processes occur and the bottom consists of a sing…

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Principal Investigator:
  • Heather Durham, McGill University

Epigenetics and mental health: the Canadian neuroepigenetics network

Project Overview

Psychiatry, like all areas of medicine and biology, has long considered the origins of individual differences. This issue ultimately produced a nature vs nurture schism that divided researchers who emphasized the importance of environmental influences from those who considered the importance of heri…

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Principal Investigator:
  • Michael J. Meaney, Douglas Mental Health University Institute
Team Members:
  • Paul R. Albert, Ottawa Hospital Research Institute
  • Guillaume Bourque, McGill University
  • Gustavo Turecki, Douglas Hospital Research Centre
  • Michael Kobor, University of British Columbia
  • Thomas Boyce, University of British Columbia
  • Joanna Holbrook, Singapore Institute for Clinical Sciences

Evaluating therapeutic stimulation in a mouse model of perinatal stroke

Project Overview

Neonatal strokes occur in approximately 1 in 1500 term births and is the leading cause of hemiplegic cerebral palsy (HCP). The ischemic event leaves most children with life-long motor impairments, and in many cases the effects of rehabilitation are minimal. One potential mechanism for further enhanc…

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Principal Investigator:
  • Greg Silasi, University of Ottawa

Evaluation of electrical activity as a tumour suppressor in medulloblastoma

Project Overview

Dr. Garzia works on a type of pediatric brain cancer called medulloblastoma. Kids affected by this tumor are either not cured or experience severe side effects due to the aggressive therapy. This proposal explores a possible causative link between altered neural activity and brain tumors. The team h…

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Principal Investigator:
  • Livia Garzia, McGill University Health Centre Research Institute (RI-MUHC)

Evaluation of Long-Axis Hippocampal Subfield Volumetry as a neuroimaging biomarker for Alzheimer’s disease

Project Overview

The hippocampus is the brain region which shows the most severe changes in patients with Alzheimer’s disease. Magnetic resonance imaging can be used to measure these changes in order to improve diagnosis and evaluate potential treatment options for patients with Alzheimer’s disease. The hippoca…

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Principal Investigator:
  • Trevor Steve, University of Alberta

Evaluation of the Kids Write Network (KWN) intervention with children of severely ill parents: a qualitative and quantitative pilot study

Project Overview

Adolescence represents a unique developmental window of the life cycle to adopt healthy behaviours that will support psychosocial adjustment and well-being during adolescence and adulthood (World Health Organization, 2001). This research project seeks to evaluate the Kids Write Network (KWN) interv…

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Principal Investigator:
  • Danielle Groleau, McGill University
Team Members:
  • Ingrid Sladeczek, McGill University

Examining the role of KCC2 in maintaining the balance between excitation and inhibition in ALS

Project Overview

In this project, Dr. Sahara Khademullah will establish whether a protein called KCC2 (potassium chloride cotransporter 2), which is found to be lower in people with sporadic ALS than in people without the disease, is a viable target to prevent or stop ALS progression. Dr. Khademullah will determine …

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Principal Investigator:
  • Sahara Khademullah, Université Laval

Exploitation of a new pharmacological target for the development and validation of new anti-inflammatory drugs

Project Overview

Neuroinflammation has been implicated in a diverse array of degenerative conditions, ranging from Multiple Sclerosis  to  Alzheimer’s  disease.  Dr. Gros and team previously  uncovered genes  that  can  prevent  neuroinflammation  and provide new opportunities for drug discovery for a va…

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Principal Investigator:
  • Philippe Gros, McGill University

Exploring the involvement of TDP-43 SUMOylation in ALS pathogenesis

Project Overview

TDP-43 is an essential DNA/RNA binding protein at the epicenter of Amyotrophic Lateral Sclerosis (ALS). Nearly all cases of ALS present with TDP-43 pathology involving nuclear to cytoplasmic mislocalization and aggregation, however only a small subset of cases involve mutations in TDP-43. Therefore,…

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Principal Investigator:
  • Maxime Rousseaux, University of Ottawa
Team Members:
  • Martin L. Duennwald, University of Western Ontario

From Space to Memory Under Pathological Tau

Project Overview

Alzheimer’s Association International Research Grant Program: Alzheimer’s Association Research Fellowship (AARF) Understanding the neural basis of Alzheimer’s disease (AD) is critical for early detection and improving quality of life. Among the earliest signs of preclinical AD are navigation i…

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Principal Investigator:
  • James Carmichael, Douglas Hospital Research Center

Functional Connectivity and Cognitive Decline in a Mouse Model of Alzheimer’s Disease

Project Overview

Alzheimer’s disease is a leading cause of dementia and cognitive decline. Currently, there is no treatment for Alzheimer’s disease but there are treatment strategies and lifestyle factors that to some extent, slow the progression of the disease. In our previously funded research we used a mouse …

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Principal Investigator:
  • Jonathan Epp, University of Calgary
Team Members:
  • Derya Sargin, University of Calgary
  • Liisa Galea, University of British Columbia
  • Dylan Terstege, University of Calgary
  • Kabirat Adigun, University of Calgary

Functional hyperalignment in pediatric fMRI

Project Overview

Brain scans from MRI machines are an important research tool for studying psychiatric and neurological disorders in children. MRI lets us study brain structure, and functional MRI (fMRI) lets us also study brain function. In fMRI, each child’s brain images need to be lined up in a special way so t…

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Principal Investigator:
  • Tamara Vanderwal, University of British Columbia

Gangliosides in Huntington’s disease: from bench to clinics and back

Project Overview

Huntington disease (HD) is an inherited disorder that causes progressive malfunctioning and death of parts of the brain that control movement, reasoning and emotions. HD patients also suffer from depression and personality changes.  There is no cure for HD. Symptoms progress steadily until patients…

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Principal Investigator:
  • Simonetta Sipione, University of Alberta
Team Members:
  • Jonathan Curtis, University of Alberta
  • Sylvain Chouinard, CHUM Research Centre, University of Montréal
  • Oksana Suchowersky, University of Alberta
  • Justyna Sarna, University of Calgary
  • Richard Fahlman, University of Alberta