Directory of funded grants

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827 results found

Identification of novel ALS targets and development of non-invasive nanodiscs for ASO delivery

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    Rising Stars Trainee Awards

  • Province

    Ontario

  • Start Date

    2026

  • Total Grant Amount

    $12,000

Project Overview

Amyotrophic Lateral Sclerosis (ALS) can result from many different mutations in the same gene, making mutation-specific treatments challenging. This project focuses on using antisense oligonucleotides (ASOs) to selectively target mutant RNA from the VCP gene, reducing production of the harmful protein while preserving the normal version. To overcome the major…

Project Ongoing

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Characterization of Glutamatergic Premotor Spinal V3 Interneurons in a SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    Rising Stars Trainee Awards

  • Province

    Nova Scotia

  • Start Date

    2026

  • Total Grant Amount

    $12,000

Project Overview

Amyotrophic Lateral Sclerosis (ALS) is a progressive disease that destroys the motor neurons needed for movement, speech, and breathing, but new research shows that other spinal cord cells called interneurons may be affected even earlier. This project focuses on V3 interneurons, which help coordinate movement and appear to die off…

Project Ongoing

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Evaluation of the role of EMMPRIN and MMP-9 in extracellular matrix degradation during ALS

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    Rising Stars Trainee Awards

  • Province

    Québec

  • Start Date

    2026

  • Total Grant Amount

    $12,000

Project Overview

Amyotrophic Lateral Sclerosis (ALS) is a fatal disease that progressively destroys motor neurons, leading to paralysis and death, with no current cure. This project investigates how the protein EMMPRIN and the enzyme MMP-9 may contribute to ALS by degrading the extracellular matrix, which supports motor neurons. Using an ALS mouse…

Project Ongoing

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Targeting Cryptic Exon Inclusion to Modify the G3BP1 Interactome in Amyotrophic Lateral Sclerosis

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    Rising Stars Trainee Awards

  • Province

    Québec

  • Start Date

    2026

  • Total Grant Amount

    $12,000

Project Overview

Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD) are devastating diseases in which a protein called TDP-43 ends up in the wrong part of the cell, disrupting its normal role in managing RNA. This loss of TDP-43 function leads to problems with another protein, G3BP1, which is needed for cells…

Project Ongoing

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Next Gen Award in Parkinson’s Disease Research

  • Grant Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Parkinson's

  • Competition

    Rising Stars Trainee Awards

  • Province

    Ontario

  • Start Date

    2026

  • Total Grant Amount

    $12,000

Project Overview

Contribution of stress-associated neurovascular alterations in Parkinson’s disease and high rates of depression Parkinson’s disease (PD) is well known for its motor symptoms, but depression and anxiety affect up to half of patients and often appear years before diagnosis. This project will investigate how chronic stress and a key PD…

Project Ongoing

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