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Our directory of funded grants

406 result(s) found

Enhancing the efficacy of heat shock protein inducers by cotreatment with a histone deacetylase inhibitor – A therapeutic strategy for ALS

Project Overview

In ALS and many other neurodegenerative diseases, one of the defining characteristics is that proteins can become misfolded and clump together, potentially damaging nerve cells. When a healthy body responds to stress, protective mechanisms increase the production of heat shock proteins that help pre…

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Principal Investigator:
  • Heather Durham, McGill University
Team Members:
  • Chantelle Sephton, Université Laval
  • Richard Robitaille, Université de Montréal
  • Josephine Nalbantoglu, McGill University

Epigenetic mechanisms underlying dendritic atrophy in ALS

Project Overview

Motor neurons are made up of three distinct regions. The top of the neuron is composed of branches like a tree called dendrites that receive information to transmit. The middle part of the neuron is called the cell body where the majority of the life processes occur and the bottom consists of a sing…

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Principal Investigator:
  • Heather Durham, McGill University

Epigenetics and mental health: the Canadian neuroepigenetics network

Project Overview

Psychiatry, like all areas of medicine and biology, has long considered the origins of individual differences. This issue ultimately produced a nature vs nurture schism that divided researchers who emphasized the importance of environmental influences from those who considered the importance of heri…

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Principal Investigator:
  • Michael J. Meaney, Douglas Mental Health University Institute
Team Members:
  • Paul R. Albert, Ottawa Hospital Research Institute
  • Guillaume Bourque, McGill University
  • Gustavo Turecki, Douglas Hospital Research Centre
  • Michael Kobor, University of British Columbia
  • Thomas Boyce, University of British Columbia
  • Joanna Holbrook, Singapore Institute for Clinical Sciences

Evaluating an innovative e-mental health solution to support youth with mental health disorders in Northwestern Ontario

Project Overview

Many youth suffer from mental health-related brain disorders which can have devastating consequences Effective treatment is desperately needed. Youth in underserviced areas such as Northwestern Ontario have increased need for and decreased access to mental health treatment, especially those in rural…

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Principal Investigator:
  • Aislin Mushquash, Lakehead University

Evaluating the frequency and impact of structural variation in amyotrophic lateral sclerosis (ALS)

Project Overview

Dr. Hubert van Tol Travel Fellowship Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that lacks treatment options, and much remains to be understood regarding an individual’s genetic susceptibility to the disease. Recently, we were able to use large DNA sequencing datasets…

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Principal Investigator:
  • Allison A. Dilliott, McGill University

Evaluating therapeutic stimulation in a mouse model of perinatal stroke

Project Overview

Neonatal strokes occur in approximately 1 in 1500 term births and is the leading cause of hemiplegic cerebral palsy (HCP). The ischemic event leaves most children with life-long motor impairments, and in many cases the effects of rehabilitation are minimal. One potential mechanism for further enhanc…

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Principal Investigator:
  • Greg Silasi, University of Ottawa

Evaluation of electrical activity as a tumour suppressor in medulloblastoma

Project Overview

Dr. Garzia works on a type of pediatric brain cancer called medulloblastoma. Kids affected by this tumor are either not cured or experience severe side effects due to the aggressive therapy. This proposal explores a possible causative link between altered neural activity and brain tumors. The team h…

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Principal Investigator:
  • Livia Garzia, McGill University Health Centre Research Institute (RI-MUHC)

Evaluation of Long-Axis Hippocampal Subfield Volumetry as a neuroimaging biomarker for Alzheimer’s disease

Project Overview

The hippocampus is the brain region which shows the most severe changes in patients with Alzheimer’s disease. Magnetic resonance imaging can be used to measure these changes in order to improve diagnosis and evaluate potential treatment options for patients with Alzheimer’s disease. The hippoca…

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Principal Investigator:
  • Trevor Steve, University of Alberta

Evaluation of the Kids Write Network (KWN) intervention with children of severely ill parents: a qualitative and quantitative pilot study

Project Overview

Adolescence represents a unique developmental window of the life cycle to adopt healthy behaviours that will support psychosocial adjustment and well-being during adolescence and adulthood (World Health Organization, 2001). This research project seeks to evaluate the Kids Write Network (KWN) interv…

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Principal Investigator:
  • Danielle Groleau, McGill University
Team Members:
  • Ingrid Sladeczek, McGill University

Examining the role of KCC2 in maintaining the balance between excitation and inhibition in ALS

Project Overview

In this project, Dr. Sahara Khademullah will establish whether a protein called KCC2 (potassium chloride cotransporter 2), which is found to be lower in people with sporadic ALS than in people without the disease, is a viable target to prevent or stop ALS progression. Dr. Khademullah will determine …

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Principal Investigator:
  • Sahara Khademullah, Université Laval

Exploitation of a new pharmacological target for the development and validation of new anti-inflammatory drugs

Project Overview

Neuroinflammation has been implicated in a diverse array of degenerative conditions, ranging from Multiple Sclerosis  to  Alzheimer’s  disease.  Dr. Gros and team previously  uncovered genes  that  can  prevent  neuroinflammation  and provide new opportunities for drug discovery for a va…

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Principal Investigator:
  • Philippe Gros, McGill University

Exploring the involvement of TDP-43 SUMOylation in ALS pathogenesis

Project Overview

TDP-43 is an essential DNA/RNA binding protein at the epicenter of Amyotrophic Lateral Sclerosis (ALS). Nearly all cases of ALS present with TDP-43 pathology involving nuclear to cytoplasmic mislocalization and aggregation, however only a small subset of cases involve mutations in TDP-43. Therefore,…

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Principal Investigator:
  • Maxime Rousseaux, University of Ottawa
Team Members:
  • Martin L. Duennwald, University of Western Ontario

F-words Foundations for families & service providers training program

Project Overview

CanChild’s ‘F-words for Child Development’ offer a fresh way for everyone to look at health. Based on WHO concepts, they present a holistic, strengths-based, function-promoting, family-centred approach to child health. These ideas have captured the attention of families and service providers (…

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Principal Investigator:
  • Peter Rosenbaum, McMaster University
Team Members:
  • Andrea Cross, McMaster University
  • Rachel Teplicky, McMaster University

From Space to Memory Under Pathological Tau

Project Overview

Alzheimer’s Association International Research Grant Program: Alzheimer’s Association Research Fellowship (AARF) Understanding the neural basis of Alzheimer’s disease (AD) is critical for early detection and improving quality of life. Among the earliest signs of preclinical AD are navigation i…

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Principal Investigator:
  • James Carmichael, Douglas Hospital Research Center

Functional Connectivity and Cognitive Decline in a Mouse Model of Alzheimer’s Disease

Project Overview

Alzheimer’s disease is a leading cause of dementia and cognitive decline. Currently, there is no treatment for Alzheimer’s disease but there are treatment strategies and lifestyle factors that to some extent, slow the progression of the disease. In our previously funded research we used a mouse …

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Principal Investigator:
  • Jonathan Epp, University of Calgary
Team Members:
  • Derya Sargin, University of Calgary
  • Liisa Galea, University of British Columbia
  • Dylan Terstege, University of Calgary
  • Kabirat Adigun, University of Calgary

Functional hyperalignment in pediatric fMRI

Project Overview

Brain scans from MRI machines are an important research tool for studying psychiatric and neurological disorders in children. MRI lets us study brain structure, and functional MRI (fMRI) lets us also study brain function. In fMRI, each child’s brain images need to be lined up in a special way so t…

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Principal Investigator:
  • Tamara Vanderwal, University of British Columbia

Gangliosides in Huntington’s disease: from bench to clinics and back

Project Overview

Huntington disease (HD) is an inherited disorder that causes progressive malfunctioning and death of parts of the brain that control movement, reasoning and emotions. HD patients also suffer from depression and personality changes.  There is no cure for HD. Symptoms progress steadily until patients…

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Principal Investigator:
  • Simonetta Sipione, University of Alberta
Team Members:
  • Jonathan Curtis, University of Alberta
  • Sylvain Chouinard, CHUM Research Centre, University of Montréal
  • Oksana Suchowersky, University of Alberta
  • Justyna Sarna, University of Calgary
  • Richard Fahlman, University of Alberta

Generating expanded repeats in the C9ORF72 ortholog in zebrafish

Project Overview

Over the past several years, zebrafish have proven to be a valuable model to study motor neuron degeneration and search for new treatments. To date, several key mutations that cause ALS in humans (SOD1, TDP-43, FUS, etc.) have been introduced to zebrafish resulting in motor neuron dysfunction and an…

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Principal Investigator:
  • Gary Armstrong,

    Montreal Neurological Institute, McGill University

Genetic and therapeutic dependencies in SHH driven childhood medulloblastoma

Project Overview

Medulloblastoma is the most common malignant brain tumour of childhood, affecting 60-80 Canadian children per year. The treatment for medulloblastoma comprises surgery, followed by radiation to the entire brain and spinal cord, and high doses of non-specific chemotherapy. Despite such aggressive tre…

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Principal Investigator:
  • Vijay Ramaswamy, The Hospital for Sick Children

Genomic markers of cerebral small vessel ischemia

Project Overview

Damage to the small blood vessels of the brain is a major contributor to stroke and dementia. While risk factors for vascular disease such as smoking, diabetes, high blood pressure and elevated cholesterol contribute to small vessel disease, we currently lack methods to identify patients at risk of …

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Principal Investigator:
  • Liam Brunham, University of British Columbia