Répertoire des subventions financées

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753 ésultat(s) trouvé(s)

Vascular innervation and blood-brain barrier dysfunction in Huntington’s disease using human iPSC-derived vascularized brain organoids.

  • Domaine de recherche

    Neurodegeneration

  • Disease Area

    Other

  • Compétition

    Huntington Society of Canada - Brain Canada Undergraduate Student Fellowship

  • Province

    Québec

  • Date de Début

    2025

  • Montant total du financement

    $5,000

Aperçu du projet

"Vascular pathology, such as loss of neurovascular coupling and disruption of the blood-brain barrier (BBB), has been documented in Huntington’s disease (HD). Loss of BBB integrity could lead to altered brain homeostasis and exacerbated neuroinflammation, which would aggravate neurodegenerative processes occurring over the course of HD onset and progression. Therefore,…

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Evaluating DLK activity in brain samples from Huntington’s disease patients

  • Domaine de recherche

    Neurodegeneration

  • Disease Area

    Other

  • Compétition

    Huntington Society of Canada - Brain Canada Undergraduate Student Fellowship

  • Province

    Ontario

  • Date de Début

    2025

  • Montant total du financement

    $5,000

Aperçu du projet

"Background:Within the realm of neurodegenerative diseases, there is still a lack of effective disease-modifying treatments. Huntington’s Disease (HD) is no less immune to this issue, with only symptomatic treatment options being available for patients. In other neurodegenerative diseases, a Dual Leucine Zipper Kinase (DLK) has been identified as a novel…

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Optimizing nanodiscs to improve antisense oligonucleotide delivery in the treatment of Huntington disease.

  • Domaine de recherche

    Neurodegeneration

  • Disease Area

    Other

  • Compétition

    Huntington Society of Canada - Brain Canada Undergraduate Student Fellowship

  • Province

    Ontario

  • Date de Début

    2025

  • Montant total du financement

    $5,000

Aperçu du projet

  "Antisense oligonucleotides (ASOs) are synthetic single-stranded DNA/RNA that are useful in the targeting of mRNA sequences. Their versatility allows them to enhance potency, longevity and bioavailability, making them a popular therapeutic for neurodegenerative diseases and a leading approach in clinical trials for Huntington disease (HD). However, the blood-brain barrier…

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Investigating S-Nitrosylation of MCUB in Mitochondrial Calcium Dysregulation and Huntington’s Disease

  • Domaine de recherche

    Neurodegeneration

  • Disease Area

    Other

  • Compétition

    Huntington Society of Canada - Brain Canada Undergraduate Student Fellowship

  • Province

    Ontario

  • Date de Début

    2025

  • Montant total du financement

    $5,000

Aperçu du projet

"Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder characterized by progressive motor impairment and cognitive decline. Mitochondrial dysfunction is a central feature of HD pathophysiology, contributing significantly to neuronal death. Heritable mutant huntingtin protein disrupts mitochondrial dynamics, impairs oxidative phosphorylation and leads to bioenergetic deficits. A key component of…

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Plateforme intégrée de données mésoscopiques de neuro-imagerie (MIND)

  • Type de subvention

    Platform grants

  • Domaine de recherche

    Neurotechnology

  • Disease Area

    Other

  • Compétition

    2024 Platform Support Grants

  • Province

    Ontario

  • Date de Début

    2025

  • Montant total du financement

    $2,850,000

  • Contribution Santé Canada

    $1,425,000

Aperçu du projet

The MIND Platform is a groundbreaking initiative that will revolutionize brain research by allowing scientists to capture and analyze unprecedented detailed images of the brain at both large and small scales. This advanced technology combines ultra-powerful MRI and lightsheet microscopy, which enables researchers to see the brain's structure and activity…

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