Répertoire des subventions financées

Using mobile technology to inform driving decision-making in dementia

Aperçu du projet

A major challenge in dementia care is determining the point at which driving becomes significantly compromised for people with dementia (PWD). Although physicians are expected to play a role in the driving decision-making process, many are reluctant to address this topic. Physicians typically rely on cognitive tests to assess fitness-to-drive…

Patient-reported outcome measures for social robots in dementia care

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Improving independence and quality of life for persons living with dementia (PLWD) and their care partners can be realized by complementing human care with robotic assistive technologies. Social robots are promising in their potential to support the cognitive health of older adults and are already being deployed in many dementia-specific…

Mind Over Matter Magazine (Volume 15)

Loss of C9orf72 disrupts nucleoporins and contributes to TDP-43 mislocalization

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Subcellular compartmentalization between the nucleus and cytoplasm is primarily governed by two systems; 1) active nucleocytoplasmic transport (NCT) regulated by Ran-GTPase and involving nuclear transport receptors such as Importin β-1, and 2) macromolecular nuclear pore complexes (NPCs), comprised of >30 nucleoporin (Nups) embedded in the nuclear envelope. FG-Nups, the largest…

Rational targeting of FUS and TDP-43 protein assemblies for diagnostics and treatment of ALS

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The project addresses a grand challenge in ALS, the integration of a multi-targeted and personalized approach to patients with a rational strategy focusing on a unifying pivotal mechanism of the disease. We seek to test the extended “prion hypothesis”, which suggests that ALS progression is driven by a self-propagating buildup…