Répertoire des subventions financées

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557 ésultat(s) trouvé(s)

Safety and feasibility of focused ultrasound-enabled liquid biopsy in patients with brain tumours

  • Type de programme

    Team grants

  • Domaine de recherche

    Cancer

  • Disease Area

    Brain Cancer

  • Compétition

    CCS/CIHR/BC Spark Grant: Novel Technology Applications in Cancer Prevention and Early Detection

  • Province

    Ontario

  • Date de Début

    2021

  • Montant total du financement

    $150,000

  • Contribution Santé Canada

    $75,000

Aperçu du projet

Need for project: Neuropathological diagnoses of brain tumours require invasive neurosurgical biopsies that carry a risk of morbidity or mortality to patients. There has been growing interest in the use of non-invasive liquid biopsies to sample cell-free circulating tumor DNA (ctDNA) for genomic and epigenomic analyses but the abundance of…

Projet en cours

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Mutations in the gene encoding the molecular chaperones DnaJC7 in amyotrophic lateral sclerosis

  • Type de programme

    Team grants

  • Domaine de recherche

    Neurodegeneration

  • Disease Area

    ALS FR

  • Compétition

    Société canadienne de la SLA - Fondation Brain Canada - Bourses de découverte

  • Province

    Ontario

  • Date de Début

    2021

  • Montant total du financement

    $125,000

  • Contribution Santé Canada

    $62,500

Aperçu du projet

In 2019, a team of scientists led by co-recipient Dr. Sali Farhan discovered a new genetic cause of ALS called DNAJC7. Subsequent work revealed that mutations in the DNAJC7 gene lead to production of a protein that is unable to perform its normal function in cells. However, it is not…

Projet en cours

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Crosstalk between immune response and metabolic signaling: targeting leptin/AMPK axis to restore metabolic homeostasis in ALS

  • Type de programme

    Team grants

  • Domaine de recherche

    Neurodegeneration

  • Disease Area

    ALS FR

  • Compétition

    Société canadienne de la SLA - Fondation Brain Canada - Bourses de découverte

  • Province

    Québec

  • Date de Début

    2021

  • Montant total du financement

    $125,000

  • Contribution Santé Canada

    $62,500

Aperçu du projet

Increased metabolism (hypermetabolism) is a characteristic often associated with more aggressive, faster progressing cases of ALS. Recently, after studying blood plasma samples from people with more rapidly progressing disease, Dr. Jasna Kriz discovered that fast progressing individuals often have decreased levels of a hormone called leptin, and increased levels of…

Projet en cours

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Cytosolic DNA sensing in ALS-related neuroinflammation

  • Type de programme

    Team grants

  • Domaine de recherche

    Neurodegeneration

  • Disease Area

    ALS FR

  • Compétition

    Société canadienne de la SLA - Fondation Brain Canada - Bourses de découverte

  • Province

    British Columbia

  • Date de Début

    2021

  • Montant total du financement

    $125,000

  • Contribution Santé Canada

    $62,500

Aperçu du projet

Recently, Dr. Honglin Luo, in collaboration with Dr. Neil Cashman, discovered that mutations in the ALS-linked SOD1 gene result in activation of a specific neuroinflammatory pathway called cGAS-STING. Neuroinflammation is thought to play an important role in the progression of ALS and activation of this specific pathway has been identified…

Projet en cours

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Targeting metabolic dysfunction in ALS

  • Type de programme

    Team grants

  • Domaine de recherche

    Neurodegeneration

  • Disease Area

    ALS FR

  • Compétition

    Société canadienne de la SLA - Fondation Brain Canada - Bourses de découverte

  • Province

    Québec

  • Date de Début

    2021

  • Montant total du financement

    $125,000

  • Contribution Santé Canada

    $62,500

Aperçu du projet

In recent years, scientists have learned that changes in gut bacteria can influence overall health. In fact, evidence suggests that the gut microbiome can play a role in one’s susceptibility to diseases, including those of the brain. While studying probiotic bacterial strains in the laboratory, Dr. Alex Parker discovered that…

Projet en cours

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