Répertoire des subventions financées

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Targeting metabolic dysfunction in ALS

  • Type de programme

    Team grants

  • Domaine de recherche

    Neurodegeneration

  • Disease Area

    ALS FR

  • Compétition

    Société canadienne de la SLA - Fondation Brain Canada - Bourses de découverte

  • Province

    Québec

  • Date de Début

    2021

  • Montant total du financement

    $125,000

  • Contribution Santé Canada

    $62,500

Aperçu du projet

In recent years, scientists have learned that changes in gut bacteria can influence overall health. In fact, evidence suggests that the gut microbiome can play a role in one’s susceptibility to diseases, including those of the brain. While studying probiotic bacterial strains in the laboratory, Dr. Alex Parker discovered that…

An interdisciplinary approach to mindfulness as a quality of life improvement factor for people with ALS and their primary caregivers

  • Type de programme

    Team grants

  • Domaine de recherche

    Neurodegeneration

  • Disease Area

    ALS FR

  • Compétition

    Société canadienne de la SLA - Fondation Brain Canada - Bourses de découverte

  • Province

    Québec

  • Date de Début

    2021

  • Montant total du financement

    $121,950

  • Contribution Santé Canada

    $60,975

Aperçu du projet

Mindfulness is a therapeutic technique that teaches one to focus on the present moment, while calmly acknowledging and accepting their feelings, thoughts, and bodily sensations. Previous research has demonstrated that learning mindfulness can help with navigating grief and benefit overall quality of life. In this pilot study, the first of…

Modulating the ALS-associated C9orf72 repeat expansion in a murine model for therapeutic benefit

  • Type de programme

    Team grants

  • Domaine de recherche

    Neurodegeneration

  • Disease Area

    ALS FR

  • Compétition

    Société canadienne de la SLA - Fondation Brain Canada - Bourses de découverte

  • Province

    Ontario

  • Date de Début

    2021

  • Montant total du financement

    $125,000

  • Contribution Santé Canada

    $62,500

Aperçu du projet

Mutations in a gene called C9ORF72 are the most common genetic cause of ALS. These mutations are unique in that unlike most other ALS-linked genes, where there is often a mistake in a single piece of DNA, C9ORF72 mutations involve a section of DNA that is abnormally repeated hundreds or…

Investigating the role of mutations in CHCHD10 using ALS cell and zebrafish genetic models

  • Type de programme

    Team grants

  • Domaine de recherche

    Neurodegeneration

  • Disease Area

    ALS FR

  • Compétition

    Société canadienne de la SLA - Fondation Brain Canada - Bourses de découverte

  • Province

    Québec

  • Date de Début

    2021

  • Montant total du financement

    $125,000

  • Contribution Santé Canada

    $62,500

Aperçu du projet

In 2014, mutations in a gene called CHCHD10 were newly identified as a genetic cause of ALS. Later, in 2018, co-recipient Dr. Eric Shoubridge discovered that the role of CHCHD10 in ALS is connected to another protein, called CHCHD2. The exact way in which mutations in CHCHD10 and its interaction…

Advanced pharmacokinetics and pharmacodynamics for phase Ib/IIa trial of repurposed enoxacin therapy for patients with ALS

  • Type de programme

    Team grants

  • Domaine de recherche

    Neurodegeneration

  • Disease Area

    ALS FR

  • Compétition

    Société canadienne de la SLA - Fondation Brain Canada - Bourses de découverte

  • Province

    Québec

  • Date de Début

    2021

  • Montant total du financement

    $125,000

  • Contribution Santé Canada

    $62,500

Aperçu du projet

A Phase 1/2 clinical trial led by Dr. Angela Genge and co-recipient Dr. Eran Hornstein is currently underway to test the safety and tolerability of enoxacin in people living with ALS. Enoxacin is an antibiotic that on a cellular level is known to activate an enzyme called DICER, which in…