Skip to content
Project Directory
  • Français
Donate Now
  • Français
  • About
    • What We Do
    • Leadership
    • Team
    • Publications
    • Careers
  • Diseases/Disorders
    • One Brain
    • ALS
    • Alzheimer’s
    • Autism
    • Brain Cancer
    • Brain Injury
    • Epilepsy
    • Mental Illness
    • Multiple Sclerosis
    • Parkinson’s
    • Stroke
    • Other
  • Research
    • Programs
    • Funding Opportunities
    • Program Partners
    • Announcements
  • Impact
  • Ways To Give
    • Your Impact
    • How You Can Help
    • Events

Funded Grants

Back to results

Biological and Pathological relevance of hnRNP A1B; An alternative splice variant of TDP-43

Project Overview

In 97 per cent of ALS cases and nearly half of cases of frontotemporal dementia, the TDP-43 protein is misplaced to an area outside the cell nucleus of the motor neuron called the cytoplasm. The mislocated TDP-43 may be toxic to motor neurons because it aggregates in the cytoplasm, or because it is no longer performing its normal function in the nucleus.

Scientists have also discovered that mutations in another protein, called hnRNP A1, can cause ALS. In 2018, Dr. Christine Vande Velde discovered that when TDP-43 moves out of the cell nucleus, a new version of hnRNP A1 forms, called hnRNP A1B. Her preliminary work has shown that this new protein may be even more toxic and appears to have a greater ability to form potentially toxic clumps.

With this grant, Myriam Gagné will aim to understand how hnRNP A1B is involved in ALS disease processes by performing cell and mice experiments. She will also validate her findings using ALS tissue samples generously donated by people who had ALS.

Gagné hopes that new insights about the role of hbnRNP A1B in ALS may reveal a better understanding of disease processes and potential targets for new therapies and biomarkers.

Source: https://www.als.ca/research/als-canada-research-program/projects-funded/projects-funded-2019/

 

Principal Investigator

Myriam Gagné , Centre Hospitalier de l’Université de Montréal

Partners and Donors

ALS Society of Canada

La Fondation Vincent Bourque

Project Ongoing

Biological and Pathological relevance of hnRNP A1B; An alternative splice variant of TDP-43

  • Program Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada – Brain Canada Trainee Program 2019

  • Province

    Québec

  • Start Date

    2019

  • Total Grant Amount

    $75,000

Contact Us

1200 McGill College Avenue
Suite 1600, Montreal, Quebec
H3B 4G7

+1 (514) 989-2989 info@braincanada.ca

Playing with Marbles Podcast

Join us and take a journey to the real last great frontier – the brain.

Listen

Subscribe to Brain News

Receive our monthly electronic newsletter with updates on funded projects, upcoming events and breakthroughs in brain research.

Sign up

© 2023 Brain Canada Foundation

Registration number: 89105 2094 RR0001

  • Terms and Conditions
  • Privacy Policy

Design by Field Trip & Co