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Treatment strategies for Autism Spectrum Disorders and Fragile-X Syndrome using mouse models, via translational control modulators

  • Grant Type

    Team grants

  • Area of research

    Neurodevelopment

  • Disease Area

    Autism

  • Competition

    Azrieli Neurodevelopment Research Program

  • Province

    Québec

  • Start Date

    2014

  • Total Grant Amount

    $1,235,000

  • Health Canada Contribution

    $617,500

Project Overview

Aberrant control of protein synthesis (also termed translation) leads to pathological conditions like cancer, obesity, memory impairment and has been hypothesized to cause the development of Autism Spectrum Disorders (ASD) and Fragile-X syndrome (FXS). Synaptic connections are regulated by translation, thus impaired translational control is postulated to cause ASD. It…

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Correction of Neuronal Function in Autism

  • Grant Type

    Team grants

  • Area of research

    Neurodevelopment

  • Disease Area

    Autism

  • Competition

    Azrieli Neurodevelopment Research Program

  • Province

    Ontario

  • Start Date

    2014

  • Total Grant Amount

    $2,465,625

  • Health Canada Contribution

    $1,232,813

Project Overview

The prevalence of autism spectrum disorders (ASDs) is rising dramatically on a yearly basis and new interventional strategies are required to treat ASDs and related disorders like Fragile X syndrome. Altered communication between brain cells may lead to the defects responsible for the features that characterize autism and other neurodevelopmental…

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Restoration of visual function: a cellular reprogramming and bioengineering approach

  • Grant Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    Other

  • Competition

    W. Garfield Weston Foundation – Brain Canada Multi-Investigator Research Initiative (MIRI)

  • Province

    Ontario

  • Start Date

    2013

  • Total Grant Amount

    $1,500,000

  • Health Canada Contribution

    $750,000

Project Overview

The retina is the part of the eye that is responsible for processing visual information. Loss of neurons (nerve cells) in the central nervous system, which includes the brain and retina, is a particularly serious problem because, with few exceptions, these neurons do not regrow after they are lost in…

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Neuronal polarity defects as an underlying cause of neurological diseases.

  • Grant Type

    Team grants

  • Area of research

    Central Nervous System

  • Disease Area

    Other

  • Competition

    W. Garfield Weston Foundation – Brain Canada Multi-Investigator Research Initiative (MIRI)

  • Province

    Québec

  • Start Date

    2013

  • Total Grant Amount

    $1,500,000

  • Health Canada Contribution

    $750,000

Project Overview

Neurons are cells with long extensions that send information from one part of the nervous system to another. Two types of neural extensions exist: the dendrites, which receive the information and the axon, which carry the information to other parts of the nervous system. The structures responsible for neurons to…

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Epigenetics and mental health: the Canadian neuroepigenetics network

  • Grant Type

    Team grants

  • Area of research

    Mental Health

  • Disease Area

    Mental illness

  • Competition

    W. Garfield Weston Foundation – Brain Canada Multi-Investigator Research Initiative (MIRI)

  • Province

    Québec

  • Start Date

    2013

  • Total Grant Amount

    $1,494,900

  • Health Canada Contribution

    $747,450

Project Overview

Psychiatry, like all areas of medicine and biology, has long considered the origins of individual differences. This issue ultimately produced a nature vs nurture schism that divided researchers who emphasized the importance of environmental influences from those who considered the importance of heritable variation in the genome. This was never…

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