Brain Canada Brain Canada
FR Donate

Our directory of funded grants

311 result(s) found

Understanding stress to improve mental health

Project Overview

Recent estimates indicate that 1 in 5 Canadians are affected annually by mood, anxiety and other mental illnesses. These issues are exacerbated by stress. This is important because an acute episode of stress is the most common trigger for breakthrough presentations of many mental illnesses, and when…

See researchers on this project
Principal Investigator:
  • Jaideep Bains, University of Calgary
Team Members:
  • Stephanie Borgland, Hotchkiss Brain Institute, University of Calgary
  • Michael Hill, Hotchkiss Brain Institute, University of Calgary
  • Quentin Pittman, University of Calgary
  • Keith Sharkey, University of Calgary

Understanding the relationship between pain trajectories in children and youth with cerebral palsy and their well-being: A cohort study

Project Overview

This research will identify how pain changes over several weeks and will assess how these short-term pain trajectories impact self-reported physical and psychological well-being in children and youth with cerebral palsy. The proposed work aims to improve pain management and the clinical care for tho…

See researchers on this project
Principal Investigator:
  • Heather Shearer, Holland Bloorview

Use of bone marrow cells to deliver single chain antibodies in ALS

Project Overview

This project will use cells found in bone marrow as a potential means of delivering treatments to the diseased area in brain and spinal cord. One of the biggest hurdles in treating ALS is that even if something was developed to slow down or stop the disease, the brain and spinal cord are very diffic…

See researchers on this project
Principal Investigator:
  • Charles Krieger, Simon Fraser University

Using synthetic antibody parts to construct antibody-based imaging devices – anti-EGFR molecular targeted imaging probes for diagnosing and monitoring glioblastoma

Project Overview

To improve outcomes in brain cancer, better tools are needed to diagnose brain cancer, surgically remove brain tumours and monitor how they respond to therapy. Glioblastomas, aggressive brain cancers, are treated by surgical removal of the tumour followed by radiation and chemotherapy. A molecule fo…

See researchers on this project
Principal Investigator:
  • Clarence Geyer, University of Saskatchewan

Validation of cognitive rehabilitation program adapted to the needs of adults with brain cancer and adult survivors of childhood brain cancer.

Project Overview

Dr. Richard’s project is developing a cognitive rehabilitation program to address impaired cognitive abilities following cancer treatment in patients. Two protocols (one offering targeted rehabilitation, the other patient support and education) are being developed to address specific needs of adul…

See researchers on this project
Principal Investigator:
  • Nadine Richard, University Health Network

Validation of Connexins and Pannexins as a target for Alzheimer’s Disease

Project Overview

Alzheimer’s Disease (AD) is the most common cause of dementia, accounting for over two thirds of cases. As of 2013, there are over 44 million people with dementia worldwide. This number is estimated to increase to over 75 million in 2030; 1.4 million of these will be in Canada. Today, the combined…

See researchers on this project
Principal Investigator:
  • Christian Naus, University of British Columbia
Team Members:
  • Weihong Song, University of British Columbia
  • Juan Saez, Pontificia Universidad Católica de Chile
  • Christian Giaume, Collège de France
  • Luc Leybaert, Ghent University

Validation of ocular measures as potential biomarkers for early detection of brain amyloid and neurodegeneration

Project Overview

500,000 Canadians have dementia, a number that will double within a generation due to the ongoing aging demographics of the population, with annual costs estimated to increase from $15B currently to over $150B by the year 2050. The estimated total cost to the society including the loss of productivi…

See researchers on this project
Principal Investigator:
  • Sandra Black, Sunnybrook Health Sciences Centre
Team Members:
  • Anthony Lang, Krembil Research Institute
  • Chris Hudson , University of Waterloo
  • Lee Goldstein, Boston University
  • Barry Greenberg, Krembil Research Institute
  • Efrem Mandelcorn, Krembil Research Institute
  • Edward Margolin, Krembil Research Institute
  • Stephen Strother, Rotman Research Institute
  • Aristotle Voineskos, Centre for Addiction and Mental Health

Validation of small molecules preventing TDP-43 aggregation as a therapeutic for Amyotrophic Lateral Sclerosis

Project Overview

TDP-43 is a protein that behaves abnormally in the motor neurons of 97 per cent of people with ALS. It is usually found in the nucleus, but in people with ALS, it becomes trapped outside in the cytoplasm where it forms aggregates. One theory is that these aggregates are toxic to motor neurons. There…

See researchers on this project
Principal Investigator:
  • Marc Shenouda, University of Toronto

Wnt Signalling Circuits in Glioma Progression

Project Overview

The goal of Ms. Rajakulendran’s project is to characterize the role of Wnt signalling in glioma progression. The primary objective is to determine whether glioblastoma multiforme (GBM) is dependent on Wnt signalling for cancer stem cell self-renewal. The secondary objective is to identify the Wnt …

See researchers on this project
Principal Investigator:
  • Nishani Rajakulendran, University of Toronto

Z-BRAIN: A Zebrafish Drug Screening Platform Targeting Brain Disorders

Project Overview

The traditional target-based drug development strategy (in vitro screening) has had poor success in developing new drugs. The vast majority of Investigational New Drugs (INDs) fail in clinical trials due to toxicity or lack of efficacy. On the other hand, mammalian models are excellent tools to stud…

See researchers on this project
Principal Investigator:
  • Xiao-Yan Wen, St. Michael's Hospital
Team Members:
  • Pierre Drapeau, CHUM Research Centre, University of Montréal
  • Raymond Andersen, University of British Columbia
  • Robert Gerlai, University of Toronto
  • Georg Zoidl, York University
  • Loch Macdonald, St. Michael's Hospital
  • Andrew Baker, St. Michael's Hospital
  • Albert Wong, Centre for Addiction and Mental Health
  • Marc Ekker, University of Ottawa
  • Sidney H. Kennedy, University Health Network
  • Alan Fine, Dalhousie University
  • Janice Robertson, University of Toronto
  • Vince Tropepe, University of Toronto
  • Henry Krause, University of Toronto
  • Terry Van Raay, University of Guelph
  • Tom Schweizer, St. Michael's Hospital
  • David Munoz, St. Michael's Hospital
  • Corinne Fischer, St. Michael's Hospital
  • Thomas Steeve, St. Michael's Hospital
  • Ted Allison, University of Alberta
  • Cheryl Gregory-Evans, University of British Columbia
  • Claudia dos Santos, St. Michael's Hospital

Zebrafish as a novel animal model for the study of Zika virus neuropathogenesis in vivo

Project Overview

Infections with Zika virus (ZIKV) constitute a major global public health concern worldwide. Indeed, the recent ZIKV outbreak in the Americas revealed that infection of pregnant women can lead to congenital transmission, infection within the fetal developing brain and eventually to microcephaly in t…

See researchers on this project
Principal Investigator:
  • Laurent Chatel-Chaix, Institut National de la Recherche Scientifique