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510 results found

Aberrant tRNA function exacerbates TDP-43 misfolding and toxicity in cellular models of ALS

  • Program Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada-Brain Canada Trainee Program 2022

  • Province

    Ontario

  • Start Date

    2022

  • Total Grant Amount

    $75,000

  • Health Canada Contribution

    $37,500

Project Overview

Aberrant tRNA processing and function has the capacity to exacerbate misfolding of ALS-associated proteins and the ensuing toxicity. tRNAs mainly function to recruit amino acids to ribosomes, allowing faithful translation of mRNA molecules. Metabolites of processed tRNAs also function in cellular stress responses, such as inducing stress granule formation. The…

Project Ongoing

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Elucidating the role of stress granules dynamics in the pathogenesis of ALS

  • Program Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada-Brain Canada Trainee Program 2022

  • Province

    Ontario

  • Start Date

    2022

  • Total Grant Amount

    $75,000

  • Health Canada Contribution

    $37,500

Project Overview

The lifetime risk of developing amyotrophic lateral sclerosis (ALS) is approximately 1 in 350 for men and 1 in 440 for women, making it the most common adult-onset motor neuron disease. There is no cure and poor prognosis for this devastating neurodegenerative disease, resulting in increased mortality and morbidity. With…

Project Ongoing

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Investigating TDP-43 palmitoylation as a therapeutic target to lower protein aggregation

  • Program Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada-Brain Canada Trainee Program 2022

  • Province

    Ontario

  • Start Date

    2022

  • Total Grant Amount

    $75,000

  • Health Canada Contribution

    $37,500

Project Overview

TDP-43 (transactive response DNA-binding protein 43) is one of the few genes highly associated with ALS (amyotrophic lateral sclerosis). Although TDP-43 mutations only occur in a small subset of ALS patients, cytoplasmic inclusions that mainly consists of TDP-43 protein aggregates are present in 97% of all ALS cases as well…

Project Ongoing

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Personalized medicine for Bipolar disorder: clinical lithium response as a guide to mode of action and biomarker discovery using human neurons and biofluids

  • Program Type

    Team grants

  • Area of research

    Mental Health

  • Disease Area

    Mental illness

  • Competition

    Bell Let’s Talk – Brain Canada Mental Health Research Program

  • Province

    Québec

  • Start Date

    2022

  • Total Grant Amount

    $950,000

  • Health Canada Contribution

    $475,000

Project Overview

Bipolar Disorder (BD) is a chronic psychiatric illness, ranking in the top 10 causes of disability and mortality worldwide, due to suicide and cardiovascular death. BD affects ~3% of the global population and >500,000Canadians. Typically, the disease starts during adolescence and has a life-long course, characterized by extreme states of…

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Precision in Space and Time: Brain State-Dependent Stimulation Using Real-Time EEG and TMS

  • Program Type

    Capacity building grants

  • Area of research

    Mental Health

  • Disease Area

    Mental illness

  • Competition

    Future Leaders in Canadian Brain Research

  • Province

    Ontario

  • Start Date

    2022

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

The goal of this project is to develop new principles to treat brain disease and investigate brain function using non-invasive neurostimulation, without the side-effects of drugs. Neurostimulation is already an established treatment for many neurological and psychiatric disorders, such as major depression disorder, but the effectiveness of the method is…

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