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Our directory of funded grants

366 result(s) found

Study of the impact of glycation on ALS using an in vitro tissue-engineered model of spinal cord

Project Overview

Tissue engineering is a process that was originally designed and continues to be used for growing cells outside the body, turning them into functional tissues and organs, and applying them for clinical use. Skin grafting and developing new organs for transplant are examples of how tissue engineering…

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Principal Investigator:
  • François Berthod, CRCHUQ, Enfant-Jesus, University Laval

Summer School in Computational Sensory Motor Neuroscience (CoSMo)

Project Overview

Major breakthroughs in neuroscience have been achieved through the application of computational models to empirical research. Models are essential to connect theory to behavior and the increasingly rich and complex measures of nervous function at multiple spatial and temporal scales. That said, mode…

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Team Members:
  • Gunnar Blohm, Queen's University

Synaptic inhibition in the motor cortex of an ALS mouse model

Project Overview

ALS is a disease characterized by degeneration of both upper and lower motor neurons. Upper motor neurons are located in a region of the brain called the motor cortex and have been far less extensively studied than lower motor neurons in the spinal cord. One of the earliest detectable abnormalities …

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Principal Investigator:
  • Melanie Woodin, University of Toronto

Synaptic mechanisms in post-stroke depression

Project Overview

Stroke affects 17% of people worldwide and some estimates predict that it will soon become the most common cause of death worldwide. Post-stroke depression impacts a significant portion of patients that suffered from a stroke. The consequences of post-stroke are immense and are a severe impairment i…

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Principal Investigator:
  • Jean-Claude Béïque, University of Ottawa

Synergistic combination of IAP antagonism and immunotherapy to treat brain cancers

Project Overview

Brain cancers can be exceptionally challenging to treat, and new therapies are needed. Cancer cells can resist treatment in part through proteins that protect cells from dying called IAPs. Dr Robert Korneluk has found that combining IAP-blocking drugs with immunotherapy can kill cancer cells very ef…

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Principal Investigator:
  • Robert Korneluk, University of Ottawa/CHEO

Systematic assessment of retinal output following optogenetic vision therapy

Project Overview

Optogenetic strategies – the ability to activate normally light-insensitive neurons with light – are being used in clinical trials to restore light sensitivity to the retina of vision impaired patients. In normally sighted individuals, before visual signals reach the brain, the retina uses its c…

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Principal Investigator:
  • Stuart Trenholm, McGill University

TACKLing the challenges of PREsymptomatic sporadic Dementia – The TACKL-PRED Study

Project Overview

Dementia is becoming more prevalent with the aging of the baby boomer population and is imposing a major challenge to society, both from a financial and social perspective. Individuals suffering from dementia experience memory loss and decline in other mental abilities, which significantly impacts t…

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Principal Investigator:
  • Mario Masellis, Sunnybrook Health Sciences Centre
Team Members:
  • AmanPreet Badhwar, Université de Montréal
  • Derek Beaton, St. Michael's Hospital Center for Research Methods and Data
  • Malcolm Binns, Baycrest Health Sciences
  • Roger Dixon, University of Alberta
  • Howard Chertkow, McGill University

Tanycytic structural plasticity in circumventricular organs underlies homeostatic brain-body communication

Project Overview

Metabolic syndrome is a group of risk factors (obesity, hypertension, high fasting blood sugar, and high levels of triglycerides) that increase the risk of type 2 diabetes and cardiovascular diseases. Over 20% of adult Canadians suffer from metabolic syndrome (40% in adults over 60 years old), and e…

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Principal Investigator:
  • Masha Prager-Khoutorsky,

    McGill University

Targeting Amyloid Propagation in Alzheimer Disease: Structures, Immunology and Extracellular Vesicle Topology

Project Overview

A treatment or prevention of Alzheimer’s disease is a top priority for medical science. Small aggregates of the protein amyloid-beta (A-beta), called oligomers, have been identified as being the primary cause of brain cell death in Alzheimer’s disease. However, there are many different subtypes …

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Principal Investigator:
  • Neil Cashman, University of British Columbia
Team Members:
  • Cheryl Wellington, University of British Columbia
  • Ging-Yuek Hsiung, University of British Columbia
  • Weihong Song, University of British Columbia

Targeting metabolic dysfunction in ALS

Project Overview

In recent years, scientists have learned that changes in gut bacteria can influence overall health. In fact, evidence suggests that the gut microbiome can play a role in one’s susceptibility to diseases, including those of the brain. While studying probiotic bacterial strains in the laboratory, Dr…

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Principal Investigator:
  • Alex Parker,

    Centre hospitalier de l'Université de Montréal

Team Members:
  • Matthew Ruiz, Montreal Heart Institute, Université de Montréal

Targeting the Synaptic Pathway in Neurodevelopmental and Psychiatric Disorders

Project Overview

Autism spectrum disorders are neurodevelopmental disorders characterized by deficits in social interaction, poor communication, and restricted, stereotyped patterns of behavior. Autism and schizophrenia affect over 1% of the population, and each has strong genetic associations with 60-90% heritabili…

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Principal Investigator:
  • Ann Marie Craig,

    University of British Columbia

Team Members:
  • Michael Gordon, Brain Research Centre, University of British Columbia
  • Tim Murphy, University of British Columbia
  • Richard Brown, Dalhousie University

Targeting the telomere maintenance pathway for cancer diagnostics and therapeutics.

Project Overview

Cancer can exhibit relentless growth and relapse because of the enhanced protection of its chromosome ends. Dr. Uri Tabori is a world expert in telomeres – the protective caps at the ends of DNA. Dr. Tabori has discovered that telomeres are maintained by a section of DNA called THOR. THOR methylat…

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Principal Investigator:
  • Uri Tabori, The Hospital For Sick Children

Teaching Adolescents with type 1 Diabetes Self-compassion (TADS) to reduce diabetes distress: A randomized controlled trial

Project Overview

Self-compassion is a practice that involves acting the same way towards yourself as you would with friends and loved ones, and that you are kind and understanding towards yourself. Since self-compassion is a skill that can be taught, the team believes that it could be a strategy to improve mental he…

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Principal Investigator:
  • Marie-Eve Robinson, Children’s Hospital of Eastern Ontario Research Institute
Team Members:
  • Alexandra Ahmet, Children's Hospital of Eastern Ontario
  • Ellen Goldbloom, Children's Hospital of Eastern Ontario
  • Karine Khatchadourian, Children's Hospital of Eastern Ontario
  • Sarah Lawrence, Children's Hospital of Eastern Ontario
  • Caroline Zuijdwijk, Children's Hospital of Eastern Ontario
  • Brian Feldman, The Hospital For Sick Children
  • Jai Shah, McGill University
  • Gary Goldfield, Children's Hospital of Eastern Ontario Research Institute
  • Kuan Liu, University of Toronto
  • Andrew Leonard, Camp Banting
  • Noah Spector, Children's Hospital of Eastern Ontario
  • Saunya Dover, Children's Hospital of Eastern Ontario Research Institute

TECC-T1D3: Technology-enabled Comprehensive Care for young adults with Type 1 Diabetes and Diabetes Distress

Project Overview

Dr. Selby and his team at the Center for Addiction and Mental Health in Toronto are bringing experts in mental health and T1D care together with those who have lived experience of T1D to co-develop a solution for diabetes distress that is accessible and acceptable to people with T1D, their caregiver…

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Principal Investigator:
  • Peter Selby, Centre for Addiction and Mental Health
Team Members:
  • MaryAnn Maloney,
  • Tracy McQuire, Unity Health Network
  • Christina Mulchandani,
  • Linxi Mytkolli, Mental Health Commission of Canada
  • Bruce Perkins, Mount Sinai Health
  • Quynh Pham, University Health Network
  • Brooks Roche,
  • Barry Simon, Sinai Health Systems
  • Melanie Yeung, University Health Network
  • Kate Farnsworth, Diabetes Action Canada
  • Ishan Aditya, University of Toronto

Testing therapeutic approaches to improve cognitive dysfunction in a primate model of Alzheimer’s Disease

Project Overview

Alzheimer’s Disease (AD) is a severe dementia that is likely a result of years of buildup in the brain of molecules called amyloid-beta oligomers (AβOs). The pursuit of new disease-modifying therapeutics for AD that change the natural progression of AD early in its course is under intense investi…

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Principal Investigator:
  • Douglas Munoz, Queen's University
Team Members:
  • Stephen Scott, Queen's University
  • Douglas Cook, Queen's University
  • Ron Levy, Queen's University

Testing white matter pathway’s influence on neural communication: A combined structural and functional neuroimaging study

Project Overview

Alexandra Decker is interested in understanding how white matter development enables and constrains neural communication, which in turn, facilitates our ability to encode new memories. She will also examine how damage to white matter during development impairs neural communication, and thereby wea…

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Principal Investigator:
  • Alexandra Decker,

    University of Toronto

The Aging Brain: Circadian, Transcriptomic, and Epigenomic Dimensions

Project Overview

One of the most important questions of biomedical research is “why do we ail as we age?”. This may be in part due to a breakdown of the body’s circadian rhythm – the physiological process that tunes up or down various bodily functions during the 24 hr cycle. Another aspect of our biology tha…

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Principal Investigator:
  • Art Petronis, University of Toronto/CAMH
Team Members:
  • Jose Nobrega, Centre for Addiction and Mental Health
  • Albert Wong, Centre for Addiction and Mental Health
  • Martin Ralph, University of Toronto

The Applied Organoid Core (ApOC): a organoid production platform for modelling human brain development and disease

Project Overview

Current preclinical models to address neurological disorders fail to accurately portray human physiology. First, traditional tissue culture in which neuronal cells are grown in monolayer do not recapitulate the complex heterogeneity and function of the human brain. Second, animal models such as rode…

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Principal Investigator:
  • Liliana Attisano, University of Toronto
Team Members:
  • Jeff Wrana, Sinai Health System, Lunenfeld-Tanenbaum Research Institute
  • Laurence Pelletier, Sinai Health System, Lunenfeld-Tanenbaum Research Institute

The Automated Monitoring of Gait as a Predictor of Fall Risk

Project Overview

People with dementia are at a high risk for falls which are a leading cause of injury and can contribute to loss of independence and quality of life. Many falls could be prevented if there was a way to predict an individual’s likelihood of falling and offer interventions to reduce this risk. New r…

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Principal Investigator:
  • Babak Taati, Toronto Rehabilitation Institute