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364 result(s) found

Validation of small molecules preventing TDP-43 aggregation as a therapeutic for Amyotrophic Lateral Sclerosis

Project Overview

TDP-43 is a protein that behaves abnormally in the motor neurons of 97 per cent of people with ALS. It is usually found in the nucleus, but in people with ALS, it becomes trapped outside in the cytoplasm where it forms aggregates. One theory is that these aggregates are toxic to motor neurons. There…

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Principal Investigator:
  • Marc Shenouda, University of Toronto

Wnt Signalling Circuits in Glioma Progression

Project Overview

The goal of Ms. Rajakulendran’s project is to characterize the role of Wnt signalling in glioma progression. The primary objective is to determine whether glioblastoma multiforme (GBM) is dependent on Wnt signalling for cancer stem cell self-renewal. The secondary objective is to identify the Wnt …

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Principal Investigator:
  • Nishani Rajakulendran, University of Toronto

Z-BRAIN: A Zebrafish Drug Screening Platform Targeting Brain Disorders

Project Overview

The traditional target-based drug development strategy (in vitro screening) has had poor success in developing new drugs. The vast majority of Investigational New Drugs (INDs) fail in clinical trials due to toxicity or lack of efficacy. On the other hand, mammalian models are excellent tools to stud…

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Principal Investigator:
  • Xiao-Yan Wen, St. Michael's Hospital
Team Members:
  • Pierre Drapeau, CHUM Research Centre, University of Montréal
  • Raymond Andersen, University of British Columbia
  • Robert Gerlai, University of Toronto
  • Georg Zoidl, York University
  • Loch Macdonald, St. Michael's Hospital
  • Andrew Baker, St. Michael's Hospital
  • Albert Wong, Centre for Addiction and Mental Health
  • Marc Ekker, University of Ottawa
  • Sidney H. Kennedy, University Health Network
  • Alan Fine, Dalhousie University
  • Janice Robertson, University of Toronto
  • Vince Tropepe, University of Toronto
  • Henry Krause, University of Toronto
  • Terry Van Raay, University of Guelph
  • Tom Schweizer, St. Michael's Hospital
  • David Munoz, St. Michael's Hospital
  • Corinne Fischer, St. Michael's Hospital
  • Thomas Steeve, St. Michael's Hospital
  • Ted Allison, University of Alberta
  • Cheryl Gregory-Evans, University of British Columbia
  • Claudia dos Santos, St. Michael's Hospital

Zebrafish as a novel animal model for the study of Zika virus neuropathogenesis in vivo

Project Overview

Infections with Zika virus (ZIKV) constitute a major global public health concern worldwide. Indeed, the recent ZIKV outbreak in the Americas revealed that infection of pregnant women can lead to congenital transmission, infection within the fetal developing brain and eventually to microcephaly in t…

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Principal Investigator:
  • Laurent Chatel-Chaix, Institut National de la Recherche Scientifique