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552 results found

The impact of ALS disease variants on regulation of heat shock protein life cycles – Implications for neuronal proteostasis

  • Program Type

    Team grants

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2023

  • Total Grant Amount

    $125,000

  • Health Canada Contribution

    $62,500

Project Overview

The abnormal accumulation of misfolded proteins and aggregates is the hallmark of multiple forms of ALS and other neurodegenerative diseases. The toxicity of these aberrant proteins is compounded by deficiency in mechanisms regulating protein quality control and alterations they cause in the metabolism of mRNAs that sustain neuronal functionality. A…

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Mechanisms of focused ultRasound mEdiated BrAin cLeAniNg Coupled with enhanced mEchanosensation (REBALANCE)

  • Program Type

    Team grants

  • Disease Area

    Alzheimer’s

  • Competition

    EU Joint Programme – Neurodegenerative Disease Research (JPND)

  • Province

    Ontario

  • Start Date

    2023

  • Total Grant Amount

    $333,000

  • Health Canada Contribution

    $330,000

Project Overview

Focused ultrasound (FUS) is a non-invasive, ground-breaking technique suggested for the treatment of Alzheimer’s disease (AD). The partners of the REBALANCE consortia have demonstrated therapeutic efficacy for FUS alone and FUS stimulation combined with microbubbles. At the cellular level, FUS promotes transient opening of the blood brain barrier (BBB) and…

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F-words Foundations for families & service providers training program

  • Program Type

    Team grants

  • Area of research

    Neurodevelopment

  • Competition

    KBHN Strategic Investment Fund

  • Province

    Ontario

  • Start Date

    2022

  • Total Grant Amount

    $555,291

  • Health Canada Contribution

    $277,631

Project Overview

CanChild’s ‘F-words for Child Development’ offer a fresh way for everyone to look at health. Based on WHO concepts, they present a holistic, strengths-based, function-promoting, family-centred approach to child health. These ideas have captured the attention of families and service providers (SPs) worldwide. The uptake of the F-words, and requests…

Project Ongoing

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Community implementation and evaluation of acceptance and commitment training (ACT) for family caregivers

  • Program Type

    Team grants

  • Area of research

    Neurodevelopment

  • Competition

    KBHN Strategic Investment Fund

  • Province

    Ontario

  • Start Date

    2022

  • Total Grant Amount

    $479,141

  • Health Canada Contribution

    $239,571

Project Overview

Family caregivers of people with neurodevelopmental disabilities (NDDs) often experience stress and mental health difficulties (e.g., anxiety, depression); however, there are few services to support their wellbeing. Acceptance and Commitment Training (ACT), which increases acceptance and mindfulness skills to help people cope, may be helpful to them. Our ACT-based intervention…

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BCi-Move: Empowering severely disabled children to achieve power mobility with brain-computer interfaces (BCIs)

  • Program Type

    Team grants

  • Area of research

    Neurodevelopment

  • Competition

    KBHN Strategic Investment Fund

  • Province

    Alberta

  • Start Date

    2022

  • Total Grant Amount

    $663,000

  • Health Canada Contribution

    $331,500

Project Overview

Thousands of Canadian children living with severe physical disability are intellectually capable but unable to move independently. They are trapped inside their bodies, deprived of their fundamental human rights to interact and participate. An emerging technology, brain-computer interfaces (BCIs), are a potential solution. BCIs allow individuals to interact with their…

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