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552 results found

Selectively Targeting ERK Signaling to Treat Fragile X Syndrome and Autism

  • Program Type

    Capacity building grants

  • Area of research

    Neurodevelopment

  • Competition

    KBHN Early Career Investigator & Mentorship Awards

  • Province

    Alberta

  • Start Date

    2022

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

Autism is one of the most prevalent neurodevelopmental disorders in Canada. It has a profound impact on the health, wellness and socioeconomic wellbeing of the patients and their families. The etiology of autism is multifaceted but Extracellular signal-Regulated Kinase (ERK) pathway in the brain is a critical convergent node in…

Project Ongoing

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The development of an online peer navigation intervention for youth with neurodevelopmental disabilities

  • Program Type

    Capacity building grants

  • Area of research

    Neurodevelopment

  • Competition

    KBHN Early Career Investigator & Mentorship Awards

  • Province

    Ontario

  • Start Date

    2022

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

Background: Transition from the pediatric to adult health care system is a multi-faceted process that should include medical and psychosocial considerations. Despite the importance of ensuring successful transition and independence in the community, and the significant detrimental health outcomes related to poor transition, there has been limited implementation of effective…

Project Ongoing

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Enhancing Supports for Autistic Post-Secondary Students at the University of Calgary

  • Program Type

    Capacity building grants

  • Area of research

    Neurodevelopment

  • Competition

    KBHN Early Career Investigator & Mentorship Awards

  • Province

    Alberta

  • Start Date

    2022

  • Total Grant Amount

    $100,000

  • Health Canada Contribution

    $50,000

Project Overview

Autistic individuals are disproportionately under-represented in post-secondary institutions, with only 35% of students with autism pursuing post-secondary education. Of those individuals with autism who do enter post-secondary environments, only 39% are likely to graduate. A lack of available autism specific supports has been suggested to interfere with successful post-secondary education.…

Project Ongoing

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Neuronal reprogramming as a novel therapeutic strategy to treat Amyotrophic lateral sclerosis

  • Program Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Competition

    ALS Canada-Brain Canada Trainee Program 2022

  • Province

    Ontario

  • Start Date

    2022

  • Total Grant Amount

    $165,000

  • Health Canada Contribution

    $82,500

Project Overview

The demonstration that mature somatic cells can be converted to new, heterologous cell types, now termed “cellular reprogramming”, led to the 2012 Nobel Prize in Physiology or Medicine, and sparked an explosion of studies investigating the therapeutic potential of such an approach. Direct neuronal reprogramming refers to the conversion of…

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Aberrant tRNA function exacerbates TDP-43 misfolding and toxicity in cellular models of ALS

  • Program Type

    Capacity building grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada-Brain Canada Trainee Program 2022

  • Province

    Ontario

  • Start Date

    2022

  • Total Grant Amount

    $75,000

  • Health Canada Contribution

    $37,500

Project Overview

Aberrant tRNA processing and function has the capacity to exacerbate misfolding of ALS-associated proteins and the ensuing toxicity. tRNAs mainly function to recruit amino acids to ribosomes, allowing faithful translation of mRNA molecules. Metabolites of processed tRNAs also function in cellular stress responses, such as inducing stress granule formation. The…

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