Directory of funded grants

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556 results found

Mutations in the gene encoding the molecular chaperones DnaJC7 in amyotrophic lateral sclerosis

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Ontario

  • Start Date

    2021

  • Total Grant Amount

    $125,000

  • Health Canada Contribution

    $62,500

Project Overview

In 2019, a team of scientists led by co-recipient Dr. Sali Farhan discovered a new genetic cause of ALS called DNAJC7. Subsequent work revealed that mutations in the DNAJC7 gene lead to production of a protein that is unable to perform its normal function in cells. However, it is not…

Project Ongoing

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Crosstalk between immune response and metabolic signaling: targeting leptin/AMPK axis to restore metabolic homeostasis in ALS

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2021

  • Total Grant Amount

    $125,000

  • Health Canada Contribution

    $62,500

Project Overview

Increased metabolism (hypermetabolism) is a characteristic often associated with more aggressive, faster progressing cases of ALS. Recently, after studying blood plasma samples from people with more rapidly progressing disease, Dr. Jasna Kriz discovered that fast progressing individuals often have decreased levels of a hormone called leptin, and increased levels of…

Project Ongoing

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Cytosolic DNA sensing in ALS-related neuroinflammation

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    British Columbia

  • Start Date

    2021

  • Total Grant Amount

    $125,000

  • Health Canada Contribution

    $62,500

Project Overview

Recently, Dr. Honglin Luo, in collaboration with Dr. Neil Cashman, discovered that mutations in the ALS-linked SOD1 gene result in activation of a specific neuroinflammatory pathway called cGAS-STING. Neuroinflammation is thought to play an important role in the progression of ALS and activation of this specific pathway has been identified…

Project Ongoing

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Targeting metabolic dysfunction in ALS

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2021

  • Total Grant Amount

    $125,000

  • Health Canada Contribution

    $62,500

Project Overview

Amyotrophic lateral sclerosis (ALS) is a late-onset neurodegenerative disease with distinct genetic contributions. However, even for genetically defined components of ALS, there remains great variability in disease onset and progression. It is generally thought that a contribution of genetics, environmental factors, and time all contribute the natural history of neurodegenerative…

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An interdisciplinary approach to mindfulness as a quality of life improvement factor for people with ALS and their primary caregivers

  • Program Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Canada - Brain Canada Discovery Grants

  • Province

    Québec

  • Start Date

    2021

  • Total Grant Amount

    $121,950

  • Health Canada Contribution

    $60,975

Project Overview

Amyotrophic Lateral Sclerosis (ALS) is very much a disease of losses and adjustments. People diagnosed with this disease face a higher than normal amount of anticipatory grief specific to lost abilities, lifestyles, skill sets, social interaction and life. The need to readjust, grieve and reinvent oneself in the face of…

Project Ongoing

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