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Our directory of funded grants

4 result(s) found

Integrative discovery of ion channels as drug targets in glioblastoma

Project Overview

Ion channel (IC) proteins are known to be involved in different human diseases such as heart and brain disorders. There are many drugs that activate or inactivate ICs and they are used to treat patients with these diseases. However, less has been known about the role of ICs in cancer and no approved…

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Principal Investigator:
  • Juri Reimand, Ontario Institute for Cancer Research

Molecular characterization of transcriptional repressor capicua in GBM

Project Overview

Malignant gliomas, including oligodendrogliomas (OD) and glioblastomas (GBM), are currently incurable brain tumours with few effective treatment options. A better understanding of the molecular underpinnings of glioma is required to find new and better treatments. The goal of this study is to invest…

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Principal Investigator:
  • Gelareh Zadeh, University Health Network, Princess Margaret, University of Toronto

The feasibility of hyperpolarized 13C-Pyruvate MRI for monitoring patients with intracranial metastasis

Project Overview

Surgery and radiation are standard treatments for cancer that has spread to the brain. Recent research has revealed that cancer cells with high levels of the chemical lactate are aggressive and resist radiation therapy. Dr Charles Cunningham will study whether an enhanced imaging method that can det…

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Principal Investigator:
  • Charles Cunningham, Sunnybrook Research Institute

Using synthetic antibody parts to construct antibody-based imaging devices – anti-EGFR molecular targeted imaging probes for diagnosing and monitoring glioblastoma

Project Overview

To improve outcomes in brain cancer, better tools are needed to diagnose brain cancer, surgically remove brain tumours and monitor how they respond to therapy. Glioblastomas, aggressive brain cancers, are treated by surgical removal of the tumour followed by radiation and chemotherapy. A molecule fo…

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Principal Investigator:
  • Clarence Geyer, University of Saskatchewan