Directory of funded grants

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556 results found

Integrative discovery of ion channels as drug targets in glioblastoma

  • Program Type

    Team grants

  • Area of research

    Cancer

  • Disease Area

    Brain Cancer

  • Competition

    Canadian Cancer Society Innovation Grants

  • Province

    Ontario

  • Start Date

    2017

  • Total Grant Amount

    $196,000

  • Health Canada Contribution

    $98,000

Project Overview

Ion channel (IC) proteins are known to be involved in different human diseases such as heart and brain disorders. There are many drugs that activate or inactivate ICs and they are used to treat patients with these diseases. However, less has been known about the role of ICs in cancer…

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The feasibility of hyperpolarized 13C-Pyruvate MRI for monitoring patients with intracranial metastasis

  • Program Type

    Team grants

  • Area of research

    Cancer

  • Disease Area

    Brain Cancer

  • Competition

    Canadian Cancer Society Innovation Grants

  • Province

    Ontario

  • Start Date

    2017

  • Total Grant Amount

    $187,915

  • Health Canada Contribution

    $939,575

Project Overview

Surgery and radiation are standard treatments for cancer that has spread to the brain. Recent research has revealed that cancer cells with high levels of the chemical lactate are aggressive and resist radiation therapy. Dr Charles Cunningham will study whether an enhanced imaging method that can detect lactate can help…

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Quantitative MRI as a biomarker of tumour resistance to radiation treatment in brain metastasis

  • Program Type

    Team grants

  • Area of research

    Cancer

  • Disease Area

    Brain Cancer

  • Competition

    Canadian Cancer Society Innovation to Impact Grants

  • Province

    Ontario

  • Start Date

    2017

  • Total Grant Amount

    $441,000

  • Health Canada Contribution

    $220,500

Project Overview

Brain metastasis occurs in 20% to 40% of all cancer patients and impacts quality of life and survival. Stereotactic radiosurgery (SRS), which involves delivering high doses of radiation to the tumour, is the preferred treatment for these patients. It is also associated with a survival advantage compared to irradiation of…

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Advancing biology based therapies for rhabdoid brain tumours

  • Program Type

    Team grants

  • Area of research

    Cancer

  • Disease Area

    Brain Cancer

  • Competition

    Canadian Cancer Society Impact Grants

  • Province

    Ontario

  • Start Date

    2017

  • Total Grant Amount

    $1,214,047

  • Health Canada Contribution

    $607,024

Project Overview

Rhabdoid brain tumours are the most common brain cancers in infants. Usually these aggressive tumours are treated with intense chemotherapy and radiation therapy, which can have serious side effects. Dr Annie Huang found that these brain tumours come in 2 forms, including one that can be cured using chemotherapy alone.…

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Synergistic combination of IAP antagonism and immunotherapy to treat brain cancers

  • Program Type

    Team grants

  • Area of research

    Cancer

  • Disease Area

    Brain Cancer

  • Competition

    Canadian Cancer Society Impact Grants

  • Province

    Ontario

  • Start Date

    2016

  • Total Grant Amount

    $1,200,000

  • Health Canada Contribution

    $600,000

Project Overview

Brain cancers can be exceptionally challenging to treat, and new therapies are needed. Cancer cells can resist treatment in part through proteins that protect cells from dying called IAPs. Dr Robert Korneluk has found that combining IAP-blocking drugs with immunotherapy can kill cancer cells very effectively. Dr Korneluk will now…

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