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Regulation of the stress granule proteome and transcriptome by TDP-43 in ALS: biomarkers and therapeutic targets

  • Grant Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Arthur J. Hudson Translational Team Grant

  • Province

    Québec

  • Start Date

    2015

  • Total Grant Amount

    $1,685,750

  • Health Canada Contribution

    $842,875

Project Overview

When cells are under stress, one of the reactions is to form tiny clumps called stress granules that protect important genetic information while protective mechanisms kick in. Toxicity in ALS might arise from both an abnormal ability to properly form stress granules and/or a failure to disassemble stress granules after…

Project Complete

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Discovery of Therapeutic Targets for FUS- and TDP43-Dependent Forms of ALS

  • Grant Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Arthur J. Hudson Translational Team Grant

  • Province

    Ontario

  • Start Date

    2015

  • Total Grant Amount

    $1,382,685

  • Health Canada Contribution

    $691,342

Project Overview

The four most commonly studied ALS proteins are SOD1, TDP-43, FUS and C9ORF72. Of these, TDP-43 and FUS have the most in common. Not only do they share similar functions inside cells, but in motor neurons of people with ALS, they both accumulate in clumps outside of the area where…

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Preclinical and clinical studies with withanolides: Therapeutic effects, molecular signatures and biomarkers

  • Grant Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Arthur J. Hudson Translational Team Grant

  • Province

    Québec

  • Start Date

    2015

  • Total Grant Amount

    $2,478,763

  • Health Canada Contribution

    $1,239,381

Project Overview

One of the hallmarks of ALS is the presence of abnormal clumps inside motor neurons that contain various substances which include, in the majority of cases, something called TAR DNA-binding protein 43 (TDP-43). As a result, understanding the mechanisms by which TDP-43 may influence the disease may have a tremendous impact…

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Novel MRI biomarkers for monitoring disease progression in ALS

  • Grant Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Arthur J. Hudson Translational Team Grant

  • Province

    Alberta

  • Start Date

    2016

  • Total Grant Amount

    $2,946,303

  • Health Canada Contribution

    $1,473,151

Project Overview

For this project Dr. Sanjay Kalra and his team aims to improve on current techniques to use magnetic resonance imaging (MRI) as a readily available way to examine if a potential new treatment is working to slow down progression of ALS. Preliminary work by Dr. Kalra has revealed that using…

Project Ongoing

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Selective knockdown of misfolded SOD1 as a therapy for amyotrophic lateral sclerosis

  • Grant Type

    Team grants

  • Area of research

    Neurodegeneration

  • Disease Area

    ALS

  • Competition

    ALS Arthur J. Hudson Translational Team Grant

  • Province

    Manitoba

  • Start Date

    2015

  • Total Grant Amount

    $1,600,250

  • Health Canada Contribution

    $800,125

Project Overview

In some cases of ALS, it is clear that specific inherited genetic changes (called mutations) can not only cause the disease, but can do so by creating a protein (the end product of genes that actually does a function in our cells) that has an abnormal, toxic function resulting in…

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