695 results found
Cyto-iGluSnFR: A glutamate biosensor platform for brain diseases
Project Overview
The team wants to take a new breakthrough technology called Cyto-iGluSnFR (pronounced “sight-oh-eye-glue-sniffer”) and adapt it for the discovery of drugs to treat a variety of brain and eye diseases. Cyto-iGluSnFR is an engineered protein that senses the chemical glutamate, allowing scientists to see and measure the rate by which…
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See the project and researchers‘Best in Class’ Platform for Blood Brain Barrier Delivery of Therapeutics
Project Overview
The blood-brain barrier (BBB) plays an essential role in protecting the brain from blood-borne diseases. However, it blocks otherwise effective medicine from reaching the brain. Most drugs developed for treatment of central nervous system diseases fail because they aren’t optimally designed to cross the BBB. There is a need to…
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See the project and researchersAntipsychotic treatment in a genetic subtype of schizophrenia: Novel insights from neuroimaging and pharmacogenetics
Project Overview
Schizophrenia is a common and serious mental illness characterized by psychotic symptoms, social withdrawal and functional disabilities that are generally lifelong. Response to treatment with antipsychotics is variable and the manifestation of common side effects, including serious motor symptoms, is unpredictable. There is growing interest in the clinical and predictive…
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See the project and researchersBuilding the Rick Hansen Alberta Spinal Cord Injury Registry
Project Overview
There are an estimated 86,000 people living with a spinal cord injury (SCI) in Canada, with an annual economic burden of $2.67 billion for those surviving the initial injury. Approximately half of SCIs are the result of a traumatic (T) incident (ex. motor vehicle accident, sports injury) and the other…
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See the project and researchersA national coordinating neuroinformatics framework for autism and related conditions
Project Overview
New approaches in neurodevelopmental research increasingly seek to integrate enormous amounts of data through sophisticated informatics so as to determine the relationship between genotype and phenotypes, both structural and functional, as they change over time during development. Such approaches dwarf the resources of most laboratories, who are increasingly moving toward…